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Expression profile of cholecystokinin type-a receptor in gallbladder cancer and gallstone disease

Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 408-414页

作者： Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla Department of Surgical Oncology the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India Department of Pathology the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India Department of Community Medicine the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India

BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and *** cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been *** novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from *** of CCKAR was analyzed by immunohistochemistry and *** results were statistically correlated with disease history including age,sex,presence of gallstone,stage and ***:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC ***-one of the 72 (70.8%) CCKAR-positive GBC samples showed ***,consistent results also appeared in the immunoblotting ***:CCKAR expression was significantly increased in GBC compared to ***,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated ***,it has future prognostic and therapeutic implications in the management of GBC.

关键词： cholecystokinin cholecystokinin type-a receptor gallbladder cancer gallstone disease

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