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chiral detection of biomolecules based on reinforcement learning

Opto-Electronic Science 2023年第1期2卷 1-10页

作者： Yuxiang Chen Fengyu Zhang Zhibo Dang Xiao He Chunxiong Luo Zhengchang Liu Pu Peng Yuchen Dai Yijing Huang Yu Li Zheyu Fang School of Physics Peking UniversityBeijing 100871China The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of Physics&Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China

chirality plays an important role in biological processes,and enantiomers often possess similar physical properties and different physiologic *** recent years,chiral detection of enantiomers become a popular *** metasurfaces enhance weak inherent chiral effects of biomolecules,so they are used in chiral *** intelligence algorithm makes a lot of contribution to many aspects of ***,we propose a nanostructure design method based on reinforcement learning and devise chiral nanostructures to distinguish *** algorithm finds out the metallic nanostructures with a sharp peak in circular dichroism spectra and emphasizes the frequency shifts caused by nearfield interaction of nanostructures and *** work inspires universal and efficient machine-learning methods for nanophotonic design.

关键词： chiral detection metasurface deep learning cathodoluminescence

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chirality discerning and monitoring in a metal cladding optofluidic chip

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CHINESE OPTICS LETTERS 2024年第8期22卷 081202-081202页

作者： Wei, Qiheng Wang, Xueqian Shan, Hongrui Lai, Yi Li, He Dai, Hailang Chen, Xianfeng Shanghai Jiao Tong Univ Sch Phys & Astron State Key Lab Adv Opt Commun Syst & Networks Shanghai 200240 Peoples R China Shandong Normal Univ Collaborat Innovat Ctr Light Manipulat & Applicat Jinan 250358 Peoples R China Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai Key Lab Mol Engn Chiral Drugs Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Dept Head & Neck Surg Shanghai Peoples R China Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Tradit Chinese Med Shanghai Peoples R China

The metabolic process of chiral drugs plays a significant role in clinics and in research on drugs. Here, we experimentally demonstrate by all-optical means that the chiral molecules can be quickly discriminated and monitored with the ultrahigh- order modes excited in a metal cladding optofluidic chip, achieving over 5 times sensitivity with a low-dosage sample. We show that the varying concentration of the chiral drugs can be monitored both in cell and animal experiments, presenting a significant difference between chiral enantiomers at the optimal function time and the effect of the reaction. To our knowledge, this approach provides a new way to achieve important chiral discrimination for the pharmacokinetics and the pharmacodynamics and may present opportunities in indicating the health status of humans.

关键词： chiral detection ultrahigh-order guided modes metal cladding optofluidic chip high sensitivity circularly polarized light CIRCULAR-DICHROISM STATIONARY-PHASE

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Superchiral fields generated by nanostructures and their applications for chiral sensing

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Chinese Physics B 2021年第11期30卷 32-48页

作者： Huizhen Zhang Weixuan Zhang Saisai Hou Rongyao Wang Xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China

chirality is ubiquitous in natural *** with similar physical and chemical properties,chiral enantiomers could play different roles in biochemical *** of chiral enantiomers is extremely important in biochemical,analytical chemistry,and pharmaceutical *** chiroptical spectroscopic methods are disadvantageous at a limited detection sensitivity because of the weak signals of natural chiral ***,superchiral fields were proposed to effectively enhance the interaction between light and molecules,allowing for ultrasensitive chiral *** theoretical and experimental works have been devoted to generation of superchiral fields based on artificial nanostructures and their application in ultrasensitive chiral *** this review,we present a survey on these *** begin with the introduction of chiral properties of electromagnetic ***,the optical chirality enhancement and ultrasensitive chiral detection based on chiral and achiral nanostructures are discussed ***,we give a short summary and a perspective for the future ultrasensitive chiral sensing.

关键词： superchiral fields chiral detection chiral nanostructures achiral nanostructures

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