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Long chikungunya?An overview to immunopathology of persistent arthralgia

World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky Silveira-Freitas Maria Luiza Campagnolo Mariana dos Santos Cortez Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós-graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent *** clinical signs triggered by the chikungunya virus are similar to those of other ***,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and *** 40%to 60%of affected individuals report persistent arthralgia,which can last from months to *** symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune *** main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone *** review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+T cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory *** term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.

关键词： chikungunya Immunopathology Inflammation process Persistent arthralgia Signaling lymphocytic activation molecule family member 7

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chikungunya infection:A potential re-emerging global threat

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 910-915页

作者： Shanmugaraj Bala Murugan Ramalingam Sathishkumar Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar University

Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of chikungunya viral infection harmed many in Asian and African countries. chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, chikungunya, pathogenesis and epidemiology were briefly described.

关键词： Aedes mosquitoes Alphavirus Arthropod-borne disease chikungunya Non-Structural Proteins Structural Proteins

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Surveillance of chikungunya virus activity in some North-eastern states of India

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 19-25页

作者： Prafulla Dutta Siraj A.Khan Anil C.Phukan Sarat Hazarika Naba K.Hazarika Sumi Chetry Abdul M.Khan Harpreet Kaur ICMR-Regional Medical Research Center North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences Jorhat Medical College & Hospital Gauhati Medical College & Hospital Indian Council of Medical Research

Objective: To detect the prevalence pattern of chikungunya virus in three states of Northeast India. Methods: A total of 1 510 samples were collected from different private and government hospitals of Assam, Arunachal Pradesh and Meghalaya. Serum was tested for the presence of IgM antibodies against chikungunya virus followed by RT-PCR for amplification of chikungunya E1 gene region using specific primers. Results: Overall, 11.83%(172/1 454) clinical samples were positive by MAC-ELISA and/or RT-PCR assay. Asymptomatic infection was seen in 17.86%. Males were more affected than females and age group 16-30 years was mostly affected. Fever(100.00%) was the primary symptom followed by headache(72.03%) and arthralgia(41.53%). Only 118 chikungunya positive cases could be traced, of which 25.42% complained about sequelae of infection. In entomological investigation, Aedes aegypti was more predominant(92.10%) than Aedes albopictus(7.90%). No mosquito pools could be incriminated for chikungunya virus. Conclusions: In this study, chikungunya was observed to be prevalent in Assam, Arunachal Pradesh and Meghalaya. Though chikungunya is a selflimiting infection, increasing morbidity by CHIKV infection is affecting social and economic status of individual. Thus, a community empowerment to effectively control mosquito population by employing different mosquito control measures along with personal protection is mandatory to tackle future outbreak of the disease.

关键词： chikungunya Northeast India Aedes aegypti Aedes albopictus

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chikungunya in Zhejiang Province,Southeast China

Infectious Medicine

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Infectious Medicine 2023年第4期2卷 315-323页

作者： Jiangping Ren Feng Ling Ying Liu Jimin Sun Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Key Laboratory of Vaccine Prevention and Control of Infectious Disease of Zhejiang ProvinceHangzhou 310051China Zhejiang Provincial Station of Emerging Infectious Disease Control and Prevention Chinese Academy of Medical SciencesHangzhou 310051China

Background:chikungunya is emerging and reemerging word-widely in the past *** is non-endemic in Zhejiang Province,Southeast *** albopictus,one of major vectors of chikungunya,is widely-distribution in Zhejiang,and autochthonous transmission is possible after introducing chikungunya ***:Retrospectively collected the epidemiological,clinical and genetic data of chikungunya and conducted the descriptive analysis and gene sequence ***:From 2008 to 2022,29 chikungunya cases,including 26 overseas imported and 3 local cases,were reported and no cases died of *** than half of the imported cases(53.85%)were from Southeast *** peak of the imported cases was noted between August and September,and 42.31%cases onset in those 2 *** prefecture-level cities and 16 counties reported cases during the study period,with Jinghua(27.59%)and Hangzhou(24.14%)reporting the largest number of *** 3 local cases were all reported in Qujiang,Quzhou in *** imported cases,the male-female gender ratio was 2.71:1,20-30 years old cases(46.15%)and commercial service(42.31%)accounted for the highest ***,fever(100%),fatigue(94.44%),arthralgia(79.17%),headache(71.43%)and erythra(65.22%)were the most common reported *** whole-genome sequences were obtained and belonged to East/Central/South African(ECSA)or Asian ***:With the change of immigration policy,the surveillance of chikungunya should be strengthened and the ability of the case discovery and diagnosis should be improved in Zhejiang in the post-COVID-19 era.

关键词： chikungunya Imported cases Epidemiological characteristics

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Molecular genome tracking of East,Central and South African genotype of chikungunya virus in South-east Asia between 2006 and 2009

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 535-540页

作者： Kamol Suwannakarn Apiradee Theamboonlers Yong Poovorawan Center of Excellence in Clinical Virology Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalBangkokThailand

Objective:To understand the epidemiology of the East,Central and South African(ECSA) genotype of chikungunya virus(CHIKV) in terms of emerging and re-emerging infections,this study has been aimed at investigating the evolutionary parameters,genomic signatures and molecular tracking of the CHIKV ECSA genotype in South-east Asia and coastal areas of the Indian Ocean between 2006 and 2009 by using phylogenetie analysis and the Bayesian Markov Chain Monte Carlo(BMCMC) evolutionary ***:Nearly complete genome sequences of 53 CHIKV isolates from all genotypes were subjected to phylogenetie analysis and evolutionary parameter *** amino acids of 67 of ECSA genotype during 2006 to 2009 were compared for finding molecular signature *** ECSA genotype signatures were visualized to find the possible transmission root was projected onto a geographic ***: Phylogenetie analysis showed the ECSA genotype was divided into 2 *** first group comprises viruses from India and Southeast Asian *** second group consists of strains typically circulating in Sri Lanka in *** evolutionary parameters of these groups depicted the time of the most recent common ancestor at approximately 7.5 years *** genomic signatures revealed the positions of amino acid variation in each ***:The molecular evolution projected onto a geographical map showed the routes of CHIKV transmission from 2006 to *** tracking will assist in understanding transmission routes, epidemiology and molecular evolution of CHIKV.

关键词： chikungunya virus East Central and South African genotype Genomic signature Evolutionary parameter

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Surveillance of chikungunya virus in Andhra Pradesh,Southern India

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Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 860-865页

作者： CVM Naresh Kumar P Sangamithra M Rajasekhar DVR Saigopal Department of Virology College of SciencesSri Venkateswara UniversityTirupati-517502Andhra PradeshIndia Medical Officer Mobile Medical UnitDistrict Medical Health OfficeKadapa-516001Andhra PradeshIndia

Objective:The study involved survey and screening of areas suspected of chikungunya virus (CHIKV) infection,characterizing the causative agent and identifying the circulating CHIKV ***:Acute phase samples were screened by the use of RTPCR using primer set DVRChk-F/DVRChk-R whereas convalescent samples were tested by CHIKV IgM strips. Results:Two hundred and seventy five acute phase samples were screened by *** which 149(54.18%) showed positivity for *** on 192 convalescent phase samples were tested for CHIKV specific antibodies in which 125(65.10%) samples were found to be *** CHIKV strains were selected and subjected to cloning followed by nucleotide sequencing and were submitted to the Genbank DMA database with the Accession numbers(GQ119362,GQ119363, GQl 19364,and FJ225403).The Sequence analysis of "CHIK-Kadapa" strain(GQ119362) with other CHIKV isolates suggested that the present CHIKV strain has(99.23±0.52)%and 100%identity with Central East South African isolates(CESA) at nucleotide and amino acid levels *** unique non synonymous mutations S168L and D183V were depicted in El gene of the selected strains of the present ***:The 14 months survey revealed the circulation of CHIKV in 2008-2009 in Andhra Pradesh and the causative agent is identified to be of Central East South African(CESA) *** importance of the non synonymous mutations(S168L and D183V) and their role in the mobility and strength of the El-El and E1-E2 interactions needs further *** study also urges the need for intensifying the epidemiological and entomological surveillance to combat any such CHIKV outbreak in the near future.

关键词： chikungunya virus E1 gene RT-PCR Non synonymous mutations Screening

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Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon

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Asian Pacific Journal of Tropical Medicine 2015年第5期8卷 352-358页

作者： Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar Plant Genetic Engineering Lab Department of Biotechnology.Bharathiar University Department of Virology King Institute of Preventive Medicine and Research Centre for Environmental Research and Development and Loyola Institute of Frontier Energy Loyola College Vellore Institute of Technology Plant Genetic Engineering Lab Department of BiotechnologyBharathiar University

Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(***) Pers and evaluate the fraction's cytotoxicity and anti-chikungunya potential using Vero ***:The ethanolic extract of *** was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) *** phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical *** and the potential of the fraction against CHIKV were evaluated in vitro using Vero *** in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the ***:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of ***- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/***-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control ***:Luteolin and apigenin rich ethanolic fraction from *** can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus.

关键词： Antiviral activity chikungunya virus Cynodon dactylon Flavonoids Luteolin Apigenin

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Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 342-346页

作者： Piyathida Pongsiri Kesmanee Praianantathavorn Apiradee Theamboonlers Sunchai Payungporn Yong Poovorawan Center of Excellence in Clinical Virology Department of Pediatrics Faculty of Medicine.Chulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Center of Excellence in Clinical Virology Department of PediatricsFaculty of Medicine.Chulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Center of Excellence in Clinical Virology Department of PediatriesFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

Objective:To develop diagnostic test for detection chikungunya virus(CHIKV and Dengue virus (DENV) ***:We have performed a rapid,accurate laboratory confirmative method to simultaneously detect,quantify and differentiate CHIKV and DENV infection by single-step multiplex real-time ***:The assay’s sensitivity was 97.65%,specificity was 92.59% and accuracy was 95.82%when compared to conventional ***,there was no cross-reaction between CHIKV,DENV,Japanese encephalitis virus,hepatitis C,hepatitis A or hepatitis E ***:This rapid and reliable assay provides a means for simultaneous early diagnosis of CHIKV and DENV in a single-step reaction.

关键词： Multiplex Real-time RT-PCR chikungunya virus Dengue virus

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Surveillance of dengue and chikungunya infection in Dong Thap,Vietnam:A 13-month study

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 36-40页

作者： Pham Thi Kim Lien Laurence Briant Truong Ba Tang Bui Minh Trang Laurent Gavotte Emmanuel Comillot Vu Trong Duoc Tran Nhu Duong Roger Frutos Phan Thi Nga National Institute of Hygiene and Epidemiology University of Montpellier Department of Biology Dong Thap General Hospital Cirad TA-A17/GCampus International de Raillarguet

Objective:To establish a surveillance in Dong Thap,at the border with Cambodia by assessing the presence of DHNV serotypes and CHIKV among patients hospitalized at Dong Thap general ***:Cross-sectional descriptive analysis was conducted on a cohort of 131 patients hospitalized with acute fever and symptoms compatible with dengue or *** study was conducted from January 2012 to February *** full clinical picture was established as well as serological and molecular *** analysis was sequentially performed on blood samples collected on admission and an average of seven days after *** detection of IgM antibody to DENV was performed by IgM capture ELTSA and the detection of DENV and CHIKV RNA was done by reverse-transcription multiplex ***:101 patients out of 131(77%) were confirmed with *** four dengue serotypes were detected with a predominance of DENV2 and *** chikungunya infection was detected although reported in neighboring Cambodia.A differential efficiency of serological dengue detection was *** was 29%upon admission and 53%after seven days on the same patients.30 patients out of 131(23%) were negative with both DENV and ***:Dengue is at risk of being underestimated and chikungunya is not systematically *** in detection and surveillance procedures are therefore discussed to increase efficiency of dengue detection and continue the monitoring the emergence of CHIKV in Dong Thap province and in Vietnam.

关键词： Dengue chikungunya Arbovirus Dong ThapVietnam

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Comparitive evaluation of different systems of medicines and the present scenario of chikungunya in Kerala

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 443-447页

作者： Dilip C Saraswathi R Krishnan PN AK Azeem Raseena Abdul azeez Ramya Jaywin jose Al Shifa College Of Pharmacy KizhatturPerinthalmannaKeralaPin-679325

Objective:To identify the chikungunya outbreaks in both indoor and outdoor patients in some selected hospitals in our locality and the burden and magnitude of the disease,to compare different system of medicines(allopathic,Ayurvedic,homeopathy etc) and to explore the knowledge,attitude and practices of pharmacists and other health care professionals in the treatment of ***:A six-month study was carried *** history was taken from the case history,personal interview of doctors and suspected *** data such as name age,sex,location,date of onset of illness,medical history,general/systemic examination features,drugs used(allopathy,Ayurveda,homeopathy,or traditional) for the treatment,*** noted down.A simple questionnaire was prepared and distributed to various doctors practicing various systems of ***:A total of 209 suspected cases were identified from July to December,*** in the age group of 20-40 years were more *** study revealed that females were more affected than *** Grade-Ⅲ(58.73%) population was more prone to chikungunya than Grade-Ⅱ(38.75%) and Grade-Ⅰ(2.87%).It showed that fever,pain in muscles, and sleeping disturbances were the intense symptoms of *** and arthritis were concomitant diseases which worsened chikungunya *** also indicated the effective medicine for compliance is nonsteroidal antiinflammatory drugs(NSAIDS).Conclusions:From our study we found that in some places there is no proper documentation,even though there are proper guidelines framed by the relevant *** can be concluded from the study that all the systems of medicine are equally important for the management of *** effort in promoting the guidelines at local level and proper documentation helps to achieve the goal of curbing the *** is high time to increase our effort and promote these messages at grassroot level which benefits the society/ communi

关键词： chikungunya Systems of medicine Outbreak

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