检索结果-南通市图书馆

CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

Acta Pharmaceutica Sinica B 2024年第9期14卷 4059-4072页

作者： Xiaoyu Wu Zijun Bai Hui Wang Hanqing Wang Dahai Hou Yunzhu Xu Guanqun Wo Haibo Cheng Dongdong Sun Weiwei Tao Department of Surgical Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China School of Integrated Medicine Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Ningxia Medical UniversityYinchuan 750004China

Copper-based nanomaterials demonstrate promising potential in cancer ***^(+) efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione,initiating chemical dynamic therapy(CDT)and ***,a newly identified cell death modality that represents a great prospect in cancer therapy,is ***,active homeostatic systems rigorously keep copper levels within cells exceptionally low,which hinders the application of cooper nanomaterials-based ***,a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is *** Cu_(2)O and organosilica shell would degrade under the high level of glutathione and weak acidic environment,further releasing RNP and Cu^(+).The liberated Cut triggered a Fenton-like reaction for CDT and partially transformed to Cu^(2+),consuming intracellular GSH and initiating cuproptosis and ferroptosis ***,the release of RNP effectively reduced the expression of copper transporter ATP7A,subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT,cuproptosis,and *** tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis.

关键词： GSH-and pH-responsive Effective copper delivery CRISPR-Cas9 ATP7A Cuproptosis chemodynamic Ferroptosis Synergistic therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy

引用

Nano Research 2019年第12期12卷 2947-2953页

作者： Keqiang Xu Yan Cheng Jiao Yan Yanlin Feng Runxiao Zheng Xiaqhig Wu Yanjing Wang Panpan Song Haiyuan Zhang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology cf China Hefei 230026China

The development of effective nanoplatforms is extremely necessary for cancer ***,we prepared polydopamine(PDA)andammonium bicarbonate(NH4HCO3)coated and doxorubicin(Dox)loaded hollow cerium oxide(CeO2)NPs(PDAC NPs),which showedexcellent synergistic effect for photothermal therapy,chemotherapy and chemodynamic *** near infrared laser irradiation,PDA shell could absorb the incident light and convert it into heat,which could not only kill tumor cells with hyperthermia,but also trigger thedecomposition of NH4HCO3 into gaseous carbon dioxide and ammonia,leading to the destroy of PDA *** leakage of PDA furtheraccelerated Dox release and exposed CeO2 surface,in which Dox could enter into cell nucleus to induce chemotherapy,and CeO2 couldcatalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic *** fact,PDAC NPs showed an excellenttherapeutic efficacy both in vitro and in *** design provides a new strategy for synergistic tumor therapy.

关键词： photothermal therapy chemotherapy chemodynamic therapy polydopamine cerium oxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：