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Research advances on how metformin improves memory impairment in “chemobrain”

Neural Regeneration Research 2022年第1期17卷 15-19页

作者： Ahmad Alhowail Sridevi Chigurupati Department of Pharmacology and Toxicology College of PharmacyQassim UniversityBuraidahKingdom of Saudi Arabia Department of Medicinal Chemistry and Pharmacognosy College of PharmacyQassim UniversityBuraydahKingdom of Saudi Arabia

Cognitive impairment caused by chemotherapy,referred to as“chemobrain,”is observed in approximately 70% of cancer ***,it is not completely understood how chemotherapy induces cognitive dysfunction,and clinical treatment strategies for this problem are ***,used as a first-line treatment for type 2 diabetes mellitus,is reported to reduce the effects of ***,several studies have examined the effect of metformin in rescuing *** review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.

关键词： behavioral task chemobrain chemotherapy cognitive impairments inflammation memory impairment metformin neuroprotective agent review

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Cognitive Impairments in Breast Cancer Survivors Treated with Chemotherapy ——An Event Related Potentials Study

Cognitive Impairments in Breast Cancer Survivors Treated wit...

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作者： BILAL ARSHAD 重庆医科大学

学位级别：硕士

Background:Chemotherapy can lead to cognitive impairments which has been reported by many neuropsychological studies relying on cognitive *** study is performed for assessment of the effect of chemotherapy on cognitive impairments in breast cancer patients by use of objective electrophysiological measure(event related potentials,ERPs)with a big sample ***:Totally 529 primary breast cancer patients,including 178 cases at initial diagnosis and before chemotherapy(Groupl),167 cases during chemotherapy(Group2),and 184 cases during follow-up period(Group3),were examined with ERPs(P300 component)to assess the effect of chemotherapy on their cognitive function,from April 2017 to January ***:There were significant differences of P300 latency in Group2 and group3(mean follow-up period of 2.42 years)compared with group 1(364.74±15.73ms,364.02±17.12ms,355.13±19.47ms,P0.05);In patients of over 60 years old,there were no differences of P300 latency in Group1,Group2 and Group3,(P>0.05),***:Based on the study results,it is concluded that the impact of chemotherapy to induce electrophysiological cognitive impairments may be less in aged breast cancer *** age patients who are undergoing chemotherapy have less chance to get recovery in their cognitive functions,which remain impaired for several years even after completion of chemotherapy *** future research should be more focused on the significance of earlier intervention to minimize the impact of cognitive impairment on the life quality of breast cancer patients who are receiving *** registration:Retrosp

关键词： breast cancer chemotherapy cognitive deficits cognitive impairments chemobrain ERPs P300

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