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Correlation between magnetic resonance T2 image signal intensity ratio and cell apoptosis in a rabbit spinal cord cervical myelopathy model

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Chinese Medical Journal 2014年第2期127卷 305-313页

作者： Ma Lei Zhang Di Chen Wei Shen Yong Zhang Yingze Ding Wenyuan Zhang Wei Wang Linfeng Yang Dalong Department of Spinal Surgery Third Hospital of Hebei Medical University Orthopaedic Biomechanics Laborafory of Hebei Province Shijiazhuang Hebei 050051 China

Background cervical spondylotic myelopathy （CSM） is a common cause of disability in elderly *** studies have shown that spinal cord cell apoptosis due to spinal cord compression plays an important role in the pathology of *** changes in magnetic resonance imaging （MRI） T2 signal intensity ratio （SIR） are considered to be an indicator of CSM,little information is published supporting the correlation between changes in MRI signal and pathological *** study aims to testify the correlation between MRI T2 SIR changes and cell apoptosis using a CSM animal *** Forty-eight rabbits were randomly assigned to four groups：one control group and three experimental chronic compression groups,with each group containing 12 *** compression of the cervical spinal cord was implemented in the experimental groups by implanting a screw in the C3 *** control group underwent sham *** groups were observed for 3,6,or 9 months after *** T2-weighted SIR Tarlov motor scores and cortical somatosensory-evoked potentials （CSEPs） were periodically *** each time point,rabbits from one group were sacrificed to determine the level of apoptosis by histology （n=6） and Western blotting （n=6）.Results Tarlov motor scores in the compression groups were lower at all time points than the control group scores,with the lowest score at 9 months （P ＜0.001）.Electrophysiological testing showed a significantly prolonged latency in CSEP in the compression groups compared with the control *** rabbits in the compression groups showed higher MRI T2 SIR in the injury epicenter compared with controls,and higher SIR was also found at 9 months compared with 3 or 6 *** analysis showed significant apoptosis in the spinal cord tissue in the compression groups,but not in the control *** were significant differences in apoptosis degree over time （P ＜0.001）,with the 9-month group displaying the most

关键词： cervical myelopathy model apoptosis magnetic resonance imaging T2 signal intensity ratio compression

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