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Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemia-reperfusion injury

Neural Regeneration Research 2013年第7期8卷 622-632页

作者： Cuicui Yu Junke Wang Department of Anesthesiology First Affiliated Hospital of China Medical University Department of Anesthesiology Affiliated Yuhuangding Hospital Medical College of Qingdao University

Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of BcI-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.

关键词： neural regeneration brain injury penehyclidine hydrochloride cerebral ischemia-reperfusion injuryischemic cerebrovascular disease apoptosis excitatory amino acid oxygen free radicals superoxide dismutase N-methyI-D-aspartate receptor middle cerebral artery occlusion oxygen-glucose deprivation photographs-containing paper neuroregeneration

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