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湖北省暨武汉市病理生理学会第十四届学术年会

作者： Li Jun~*,Xiang Wei-chu,Ma Lian-ting,et al.~* Department of neurosurgery,Wuhan General Hospital,Guangzhou Command,PLA.Wuhan, 430070

Object:To describe the use of a new imaging tool,angiographic computed tomography,for using in cerebral vascular disease diagnosis and treatment. Methods:ACT is a new technique that provides cross-sectional CT-like images based on rotational radiography performed with a rotating C-arm-mounted flat-panel detector.240 patients received Innova

关键词： Angiographic computed tomography cerebral vascular disease interventional therapy

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Comparison of Clinical Characteristics and Outcomes of MAFLD and NAFLD in Chinese Health Examination Populations

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 777-786页

作者： Xin Xu Xiaohua Zhou Ting Tian Yuqing Ding Chengxiao Yu Wei Zhao Xiao Wang Jing Lu Wen Guo Longfeng Jiang Quanrongzi Wang Qun Zhang Ci Song Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsuChina Department of Infectious disease the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Health Promotion Center the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Radiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:The recently proposed concept of metabolic dysfunction-associated fatty liver disease(MAFLD)has remained *** aimed to describe the features and associated outcomes to examine the diagnostic ability of MAFLD for identifying high-risk ***:In this retrospective cohort study,we enrolled 72,392 Chinese participants between 2014 and *** were classified as MAFLD,nonalcoholic fatty liver disease(NAFLD),non-MAFLD-NAFLD,and a normal control *** primary outcomes were liver-related and cardiovascular disease(CVD)***-years of follow-up were calculated from enrolment to the diagnosis of the event,or the last date of data(June,2020).Results:Of the 72,392 participants,31.54%(22,835)and 28.33%(20,507)qualified the criteria for NAFLD or MAFLD,*** with NAFLD,MAFLD patients were more likely to be male,overweight,and have higher biochemical indices including liver enzyme *** MAFLD diagnosed with≥2 or≥3 metabolic abnormalities presented similar clinical *** the median follow-up of 5.22 years,919 incident cases of severe liver disease and 2,073 CVD cases were *** with the normal control group,the NAFLD and MAFLD groups had a higher cumulative risk of liver failure and cardiac-cerebral vascular *** were no significant differences in risk between the non-MAFLD-NAFLD and normal ***-MAFLD group had the highest incidence of liver-related and cardiac-cerebral vascular diseases,lean MAFLD came second,and obese-MAFLD had the lowest ***:This real-world study provided evidence for rationally assessing the benefit and practicability of the change in terminology from NAFLD to *** may be better than NAFLD in identifying fatty liver with worse clinical features and risk profile.

关键词： Metabolic-associated fatty liver disease Non-alcoholic fatty liver disease Liver-related disease Cardiac vascular disease cerebral vascular disease

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Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular diseases(Intracerebral Hemorrhage and cerebral Thrombosis) in the Longyan Area

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Chinese Journal of Biomedical Engineering(English Edition) 2021年第4期30卷 172-177页

作者： ZHANG Hong-bin HE Xiang-sheng YOU Yu-dong FAN Zhi-quan ZHANG Man’e LU Zhi-hua The Second Hospital of Longyan Longyan Fujian Province 364000China

Objective:To make statistics on the distribution of ApoE gene polymorphism in the Longyan area,provide data for the statistics of regional cerebrovascular diseases,explore the significance of ApoE gene polymorphism distribution for clinical guidance,diagnosis and treatment,and provide more suggestions for clinical diagnosis and treatment of cerebrovascular ***:800 patients with cerebrovascular disease in the Longyan area from July 2018 to April 2021 were selected as the research object,and 800 normal healthy patients were selected as the control *** data were further analyzed according to the collected patient information,and the patients were distinguished according to age and other basic information,the type of cerebrovascular disease,ApoE gene polymorphism and blood lipid test *** distribution of ApoE gene polymorphism in the cerebrovascular disease population in the Longyan area was given to determine the correlation between the incidence of cerebrovascular disease and the distribution of ApoE gene ***:In the study group,E2/E3 genotyping was the most common 400(50.00%),and E4/E4 genotyping 6(0.75%)was the least common;In the control group,E2/E4 genotyping was the most common 480(60.00%),and E2/E3 genotyping accounted for the second 290(36.25%).In the study group,E3 allele was the most common 383(47.88%),E4 allele 121(15.12%);in the control group,E2 allele was the most common391(48.88%),and E3 allele 142(17.75%).Conclusion:According to the statistics of ApoE gene polymorphism distribution in the Longyan area and the analysis of the correlation of other cerebrovascular diseases,it is found that E2/E3 genotype may be related to cerebrovascular diseases,and E3 allele may be a susceptibility *** the above analysis,the occurrence of diseases can be predicted and prevented.

关键词： ApoE gene treatment polymorphism distribution Longyan area cerebral vascular disease

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VEGF enhances cortical neurogenesis in the brain of adult rat after a transient middle cerebral artery occlusion

VEGF enhances cortical neurogenesis in the brain of adult ra...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yong-Quan WANG,Mei-Hong WANG,Yuan-Yuan MA,Feng-Yan SUN Department of Neurobiology and Institute for Biomedical Science,State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University,Shanghai 200032,China

vascular endothelial growth factor(VEGF) promotes neurogenesis in the subventricular zone(SVZ),hippocampal dentate gyrus(DG),and the striatum of adult mammalian ***,effect of VEGF on cortical neurogenesis after stroke remains ***,we intraventricularly injected human VEGF-expressive plasmids(phVEGF) into rat brains after a transient middle cerebral artery occlusion(MCAO) and examined effects of VEGF on stroke-stimulated cortical *** results showed that 5’-bromodeoxyuridine positive(BrdU,a DNA-replication marker) cells were found in ipsilateral frontal cortex at 2 weeks of reperfusion and declined over *** of phVEGF did not alter such a decline,but it significantly increased BrdU cells compared with the control plasmid(pEGFP) injection at 2,4 and 8 weeks after ***-induced cortical neurogenesis was indicated by the presence of newborn immature(BrdU-Tuj 1), newborn mature(BrdU-MAP-2),and newborn GABAergic(BrdU-GAD67) *** these neurons declined within 8 weeks after MCAO in the *** of phVEGF significantly increased BrdU-Tuj 1 neurons at 2 weeks,and BrdU-MAP-2 neurons and BrdU-GAD67 neurons at 4 and 8 weeks after *** length and branch numbers of BrdU-MAP-2 newborn neurons in the cortex were detected in both *** of phVEGF significantly increased neurite length and branch numbers of BrdU-MAP-2 newborn *** results demonstrate that VEGF enhances ischemia-induced cortical neurogenesis and maturation of newborn *** study further indicates that neuroprotection of VEGF against ischemic injury may associated with enhancement of neurogenesis in adult mammalian brains.

关键词： adult brain injury cerebral vascular disease neuroplasticity regeneration stroke

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