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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun CHEN~(1,2) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China

＜正＞Objective In the past 10 years,a technique allowing simultaneous,multisite and many neuron recordings in freely moving and behaving animals（e.g.,monkeys,rats and mice） and even in human subjects has been well developed and successfully applied in many regions of the *** state-of-the-art technique of in vivo simultaneous multisite recordings of neural ensemble responses in the brain enables a good combination with various behavioral assays in freely moving and behaving *** this report,I would like to introduce the use of this technique in study of pain in the cerebral cortex of behaving *** Microwire electrode arrays（2x4 or 2x8） were implanted into the target brain area of a rat in the aid of stereotaxic surgical *** at least 7 days of recovery, simultaneous recordings of cerebral cortical neural ensemble responses in a behaving rat were carried out using the Plexon multichannel Acquisition Processor（MAP） system and an overhead video tracker system processed by Plexon CinePlex software that enables continuous real-time behavioral tracking and synchronization of video and neural signals through interaction with the MAP system.A Plexon MAP system receives and processes the pre-amplified and filtered neural ensemble signals by RASPUTIN Software for online displaying,sorting,recording and synchronizing of the neural ensemble *** nociceptive stimuli,including mechanical,thermal and chemical modalities,were applied to the rat’s *** Long-term unitary stability was confirmed by various statistical analyses. Nociceptive neuronal units were identified by online or offline sorting from the primary somatosensory（S1） cortex and the motor cortex（MCx）.The neuronal units identified in the S1 area were wide-dynamic-range（WDR） and nociceptive-specific（NS） in nature,while those in the MCx were also responsive to noxious *** neural ensemble responses can be significantly changed by peripheral inflammatory pain state tha

关键词： simultaneous neural ensemble recordings pain cerebral cortex behaving animals

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cerebral cortex:科学家鉴别出100多个和大脑记忆发生相关的关键基因

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现代生物医学进展 2017年第26期 5203-5203页

近日,一项刊登于国际杂志cerebral cortex上的研究报告中,来自西南医学中心的研究人员通过研究鉴别出了和记忆相关的100多个关键基因,相关研究或为后期研究人员深入理解人类大脑记忆加工过程提供新的线索和希望。文章中研究者对特殊大... 详细信息

近日,一项刊登于国际杂志cerebral cortex上的研究报告中,来自西南医学中心的研究人员通过研究鉴别出了和记忆相关的100多个关键基因,相关研究或为后期研究人员深入理解人类大脑记忆加工过程提供新的线索和希望。文章中研究者对特殊大脑过程背后的基因进行了深入研究,该研究或能帮助研究人员开发新型疗法治疗记忆损伤的患者。Genevieve

关键词：癫痫症 cerebral cortex

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Elucidation of Regional Mechanical Properties of Brain Tissues Based on Cell Density

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Journal of Bionic Engineering 2021年第3期18卷 611-622页

作者： Chi Zhang Long Qian Hongwei Zhao School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China

Research on the mechanical properties of brain tissue has received extensive ***,most of the current studies have been conducted at the phenomenological *** this study,the indentation method was used to explore the difference in local mechanical properties among different regions of the porcine cerebral ***,hematoxylin-eosin and immunofluorescence staining methods were used to determine the correlation between the cellular density at different test points and mechanical properties of the porcine cerebral *** frontal lobe exhibited the strongest *** temporal lobe displayed the lowest sensitivity to changes in the indentation speed,and the occipital lobe exhibited the highest shear ***,the shear modulus of different areas of the cerebral cortex was negatively correlated with the total number of local cells per unit area and positively correlated with the number of neuronal cell bodies per unit *** of the mechanical properties of the local brain tissue can provide basic data for the establishment of a finite element model of the brain and mechanical referential information for the implantation position of brain chips.

关键词： cerebral cortex mechanical properties staining correlation cellular density

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Activation and involvement of JNK1/2 in hydrogen peroxideinduced neurotoxicity in cultured rat cortical neurons

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Acta Pharmacologica Sinica 2004年第5期25卷 88-94页

作者： Wei WANG, Can GAO, Xiao-yu HOU, Yong LIU, Yan-yan ZONG, Guang-yi ZHANG2Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China Research Center for Biochemistry and Molecular Biology Xuzhou Medical College

AIM: To investigate the role of c-Jun N-terminal protein kinase 1 and 2 (JNK1/2) and the main signal pathway forits activation in hydrogen peroxide (H2O2) induced apoptotic-like cortical cell death. METHODS: Using the modelof oxidative stress induced by H2O2, the expression and diphosphorylation of JNK1/2 was examined by immunoblottinganalysis, and neuronal apoptotic like cell death was determined by 4’,6-diamidino-2-phenylindole (DAPI) ***: The elevation in diphosphorylation level of JNK1/2 (4.40-/5.61-fold vs sham control) was associatedwith the concentration of H2O2 (0-100 mol/L) and the development of apoptotic-like cell death (11.04 %-81.01 %).There was no alteration of JNK1/2 protein expression following H2O2 treatment and recovery at different timepoints. Administration with JNK1/2 antisense oligonucleotides not only significantly decreased JNK1/2 proteinexpression and activation level, but also significantly reduced cortical cell death induced by H2O2 ***, both JNK1/2 diphosphorylation and apoptotic-like cell death were largely prevented by pretreatmentwith (5S,10R)-()-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)or omission of Ca2+ in incubation medium with ethylene glycol-bis(2-aminoethylether)-N,N,N’,N’-tetraacetic acid(EGTA). CONCLUSION: JNK1/2 is activated and participates in H2O2-induced apoptotic-like death in cultured ratcortical neurons mainly via N-methyl-D-aspartate (NMDA) receptor-mediated influx of extracellular Ca2+.

关键词： c-Jun N-terminal protein kinase calcium N-methylaspartate receptors hydrogen peroxide signaltransduction apoptosis cerebral cortex

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Foxg1 mRNA overexpression in neonatal rats following hypoxic brain injury

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Neural Regeneration Research 2011年第1期6卷 41-46页

作者： Luquan Li Yi Zheng Guoliang Mo Fang Li Jialin Yu Neonatal Diagnosis and Treatment Center Children's Hospital of Chongqing Medical University Chongqing 400014 China

Forkhead box G1 （Foxgl） is expressed during the embryonic stage and in postnatal brain regions sensitive to hypoxia/ischemia injury, such as the hippocampus and cerebral cortex. To date, very little is known about Foxgl expression changes in the brain following hypoxia injury （HI）. The present study measured Foxgl mRNA expression using reverse-transcription polymerase chain reaction on days 3, 7, 14, 28, and 56 following HI to determine self-restorative features in the injured brain. In addition, mRNA expression of other related layer markers, such as Reelin, RORB, Foxpl, Foxp2, ER81, and Otx-1, was detected following HI. Results revealed significantly decreased Foxgl mRNA expression at 3 days after HI, which significantly increased by 56 days. Reelin and Foxp2 mRNA expression were upregulated until 56 days after HI, but Foxpl and ER81 mRNA expression decreased from day 14 to 56 following HI. In addition, Otx-1 and RORI3 mRNA expression decreased from day 3 to 28 after HI. These findings revealed Fxogl mRNA overexpression and varying degrees of restoration in the neonatal rat brain following HI.

关键词： Foxgl mRNA hypoxia injury neonatal rats cerebral cortex

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Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging

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Neural Regeneration Research 2023年第1期18卷 51-56页

作者： Itzel Ortiz Flores Samuel Treviño Alfonso Díaz Department of Health Sciences School of MedicineUniversity of the Americas PueblaPueblaMexico Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico

Aging is a global phenomenon and a complex biological process of all living beings that introduces various *** this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic ***,it presents a great reduction in volume resulting from the contraction of the gray ***,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older *** a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative *** is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo *** review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and *** of these molecules have been evaluated by our research *** suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative ***,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic.

关键词： Alzheimer’s disease brain cerebral cortex cognitive function dendritic spines HC-TeTx hippocampus neurodegeneration neuronal survival neurotrophins

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Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis

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Neural Regeneration Research 2017年第8期12卷 1278-1286页

作者： Ryo Tamaki Samuel Ige Orie Beat Alessandri Oliver Kempski Axel Heimann Department of Neurosurgery Nara Medical University University Medical Center of the Johannes Gutenberg-University of Mainz Institute for Neurosurgical Pathophysiology

Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or ＂enriched environment＂ as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression（CSD） induces neurogenesis in the cerebral cortex and dentate gyrus after cerebral venous ischemia. Forty-two Wistar rats alternatively underwent sham operation（Sham）, induction of ten CSDs or venous ischemia provoked via occlusion of two adjacent superficial cortical vein followed by ten induced CSDs（CSD ＋ 2-VO）. As an additional control, 15 na？ve rats received no intervention except 5-bromo-2′-deoxyuridine（Brd U） treatment for 7 days. Sagittal brain slices（40 μm thick） were co-stained for Brd U and doublecortin（DCX; new immature neuronal cells） on day 9 or Neu N（new mature neuronal cells） on day 28. On day 9 after sham operation, cell proliferation and neurogenesis occurred in the cortex in rats. The sole induction of CSD had no effect. But on days 9 and 28, more proliferating cells and newly formed neurons in the ipsilateral cortex were observed in rats subjected to CSD ＋ 2VO than in rats subjected to sham operation. On days 9 and 28, cell proliferation and neurogenesis in the ipsilateral dentate gyrus was increased in sham-operated rats than in na？ve rats. Our data supports the hypothesis that induced cortical neurogenesis after CSD ＋ 2-VO is a direct effect of ischemia, rather than of CSD alone.

关键词： nerve regeneration cortical spreading depression two-vein occlusion adult neurogenesis stem cells cerebral cortex neural precursor cells neuron penumbra neural regeneration

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Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes

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Neuroscience Bulletin 2022年第1期38卷 47-68页

作者： Lin Yang Zhenmeiyu Li Guoping Liu Xiaosu Li Zhengang Yang State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceInstitute for Translational Brain Researchand Department of NeurologyZhongshan HospitalFudan UniversityShanghai200032China

Human cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interneurons. One of prominent features of the human cortex is enriched with glial cells, but there are major gaps in understanding how these glial cells are generated. Herein, by integrating analysis of published human cortical single-cell RNA-Seq datasets with our immunohistochemistical analyses, we show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells (tRGs) give rise to basal multipotent intermediate progenitors (bMIPCs) that express EGFR, ASCL1, OLIG2 and OLIG1. These bMIPCs undergo several rounds of mitosis and generate cortical oligodendrocytes, astrocytes and olfactory bulb interneurons. We also characterized molecular features of the cortical tRG. Integration of our findings suggests a general picture of the lineage progression of cortical radial glial cells, a fundamental process of the developing human cerebral cortex.

关键词： Radial glial cell Intermediate progenitor cell EGFR HOPX Oligodendrocyte Astrocyte Olfactory bulb interneuron cerebral cortex Human

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Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain

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Neural Regeneration Research 2017年第11期12卷 1843-1852页

作者： Ping Li Heng-xi Li Hong-yan Jiang Lie Zhu Hai-ying Wu Jin-tao Li Jiang-hua Lai College of Forensic Science Health Science CenterXi'an Jiaotong UniversityXi'anShaanxi ProvinceChina Department of Anatomy and Histology&Embryology Faculty of Basic Medical SciencesKunming Medical UniversityKunmingYunnan ProvinceChina Department of Plastic Surgery Changzheng HospitalShanghaiChina Department of Emergency and Intensive Care Unit First Affiliated HospitalKunming Medical UniversityKunmingYunnan ProvinceChina Neuroscience Institute Faculty of Basic Medical SciencesKunming Medical UniversityKunmingYunnan ProvinceChina

Platelet-derived growth factor receptor alpha （PDGFRct） is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphol- ogy of oligodendrocyte precursor cells labeled by NG2 or PDGFRa in the developing neonatal rat brain remains unclear. In this study, by immunohistochemical staining, NG2 positive （NG2＋） cells were ubiquitous in the molecular layer, external pyramidal layer, internal pyramidal layer, and polymorphic layer of the cerebral cortex, and corpus callosum, external capsule, piriform cortex, and medial septal nucleus. NG2~ cells were stellate or fusiform in shape with long processes that were progressively decreased and shortened over the course of brain development. The distribution and morphology of PDGFRct positive （PDGFRa＋） cells were coincident with NG2＋ cells. The co- localization of NG2 and PDGFRu in the cell bodies and processes of some cells was confirmed by double immunofluorescence labeling. Moreover, cells double-labeled for NG2 and PDGFRa were predominantly in the early postnatal stage of development. The numbers of NG2＋/PDGFRa＋ cells and PDGFRa＋ cells decreased, but the number of NG2＋ cells increased from postnatal days 3 to 14 in the developing brain. In addition, amoeboid microglial cells of the corpus callosum, newborn brain macrophages in the normal developing brain, did not express NG2 or PDGFRu, but NG2 expression was detected in amoeboid microglia after hypoxia. The present results suggest that NG2 and PDGFRct are specific markers of oligodendrocyte precursor cells at different stages during early development. Additionally, the NG2 protein is involved in inflammatory and pathological processes of amoeboid microglial cells.

关键词： nerve regeneration NG2 platelet-derived growth factor receptor alpha oligodendrocyte precursor cells amoeboid microglial cells OX-42 hypoxia cerebral cortex corpus callosum neural regeneration

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