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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1120-1127页

作者： Da-Wen Wu Fei-Peng Jiang Ge Ge Mei-Xia Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the association between central serous chorioretinopathy(CSC)and Helicobacter pylori(Hp)by summarizing all available ***:The Scopus,Embase,EBSCO,PubMed,Web of Science,and Cochrane Library databases for all relevant studies published from inception to October 2022 were searched,and manually searched for relevant reference lists as a *** investigating the association between CSC and Hp infection were ***,8 case-control studies were included in the Meta-analysis after study ***:The results showed no significant correlation between Hp infection and CSC[odds ratio(OR)1.89,95%confidential interval(CI)0.58–6.15,I2=96%,P=0.29].After subgroup analysis based on the degree of development of the study(developing/developed countries),it was found that the results of the two subgroups were the same as the whole,and no significant difference between the two subgroups ***-regression showed that the effect of sample size on heterogeneity among studies was more prominent(P<0.01,adjusted R^(2)=89.72%),which can explain 89.72%of the sources of ***:This Meta-analysis reveals no significant correlation between Hp infection and CSC,which still warrants further well-designed extensive sample studies to reach a more reliable conclusion and promote a better understanding of the treatment of CSC.

关键词： central serous chorioretinopathy Helicobacter pylori infection retinal diseases Meta-analysis

Efficacy and safety of subthreshold micropulse laser in the treatment of acute central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 921-927页

作者： Jian-Jie Guo Xiu-Juan Li Jing-Jing Wan Department of Ophthalmology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

·AIM:To analyze the efficacy and safety of subthreshold micropulse laser(SML)in the treatment of acute central serous chorioretinopathy(CSC).·METHODS:This is a retrospective case analysis *** 58 eyes of 58 patients were enrolled,and they were divided into different *** 39 patients were treated with SML(SML group)and 19 patients were only observed(observation group).The follow-up period was 3mo after *** best corrected visual acuity(BCVA),central retinal thickness(CRT),superficial retinal vascular density(SRVD),deep retinal vascular density(DRVD),the superficial and deep foveal avascular zone(FAZ)area,retinal light sensitivity(RLS),perfusion area of choroidal capillary layer(CCL),subfoveal choroidal thickness(SFCT)and fundus autofluorescence(FAF)were investigated.·RESULTS:The BCVA,CRT,SRVD,DRVD,the superficial and deep FAZ area,RLS,SFCT of SML group were significantly improved at 3mo(all P0.05).At the last follow-up,the BCVA and RLS in the SML group were better than those in the observation group,and CRT was lower,SRVD and DRVD,perfusion area of CCL were larger(all P<0.05).On FAF,no change of treatment spots was found after *** structural laser damage was observed on optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA),and no choroidal neovascularization was observed.·CONCLUSION:SML treatment of acute CSC can improve BCVA,RLS,and perfusion area of CCL,reduce CRT,increase SRVD and DRVD,and is safe.

关键词： central serous chorioretinopathy subthreshold micropulse laser optical coherence tomography angiography microperimetry

Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 579-588页

作者： Yang-Chen Liu Bin Wu Yan Wang Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalTianjin 300000China Nankai Eye Institute Nankai UniversityTianjin 300071China

AIM:To investigate the association of ganglion cell complex thickness(GCCt),global loss volume percentage(GLV%),and focal loss volume percentage(FLV%)with structural and functional findings among patients with chronic central serous chorioretinopathy(CCSC)and recurrent central serous chorioretinopathy(RCSC)by optical coherence tomography(OCT).METHODS:Among 29 patients with monocular affected central serous chorioretinopathy(CSC),15 had CCSC,and 14 had *** GCCt,FLV%,GLV%,and subfoveal choroidal thickness(SFCT)and sublesional choroidal thickness(SLCT)values were determined using OCT,and the association of these characteristics with neural structure parameters,choroidal morphology,features and functional alterations were estimated for the CCSC and RCSC ***:In CCSC,the affected eyes had significantly lower GCCt values than the fellow eyes in the macular regions(all P<0.05),with the highest GCCt observed in the inferior area.A significant association was found between the GCCt in different regions and the change in best corrected visual acuity(BCVA;r=-0.696;-0.695;-0.694,P<0.05)in CCSC patients.A statistically significant moderate negative correlation indicated that long-term CCSC was associated with greater differences in the GCCt in different regions between affected and fellow eyes(r=-0.562;r=-0.556;r=0.525,P<0.05).Additionally,observation of thickened SFCT was associated with a worse FLV%(r=0.599;r=0.546,P<0.05)in both ***,thickened SLCT was associated with FLV%in RCSC patients(r=0.544,P<0.05).CONCLUSION:The distribution and GCCt are associated with the duration and visual outcomes of CCSC,whereas there is no correlation among RCSC ***%may be instrumental in differentiating the various outer choroidal vessels(pachyvessels)in long-term *** results suggest that neural structure parameters may aid in estimating and predicting the recovery of altered morphology and function in CCSC and RCSC patients.

关键词： ganglion cell complex parameters choroidal thickness optical coherence tomography central serous chorioretinopathy

central serous chorioretinopathy:from glucocorticoids to light intensity

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 312-314页

作者： Amir Norouzpour Majid Abrishami Eye Research Center Khatam-A1-Anbia Eye HospitalMashhad University of Medical Sciences Mashhad 91959-65919 Iran Retina Research Center Khatam-A1-Anbia Eye HospitalMashhad University of Medical Sciences Mashhad 91959-65919 Iran

central serous chorioretinopathy （CSC） is characterized by a localized accumulation of subretinal fluid and an idiopathic focal leakage from choroidal vessels. The exact pathogenesis of CSC, however, still remains obscure. In this paper, we hypothesized that CSC may result from a response of choroidal vessels to an acute increase in the environmental light intensity leading to a focal leakage from the choroidal vessels. High levels of glucocorticoids, in our proposed model, may cause persistence rather than initiation of the focal leakage, probably by suppressing the synthesis of collagen and extracellular matrix components and inhibiting fibroblastic activity.

关键词： central serous chorioretinopathy glucocorticoids light intensity temperature choroidal vessels

Improved thickness measurement method for choroidal hyperpermeability in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1397-1403页

作者： Xing-Wang Chen Fang-Yuan Han Gang Su Le Pan Shan-Jun Cai Department of Ophthalmology Guizhou Eye HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Ophthalmology the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Zunyi Medical University Zunyi 563000Guizhou ProvinceChina

AIM:To observe choroidal thickness changes in the choroidal hyperpermeability area(CHA)in patients with central serous chorioretinopathy(CSC)after photodynamic therapy(PDT)using indocyanine green angiography(ICGA)combined with optical coherence tomography(OCT).METHODS:This was a cohort study of 17 eyes(17 patients)with *** all patients,the range of CHA was determined by *** patients were divided into two groups based on CHA covered the fovea(group A)or not(group B).All patients received half-dose verteporfin PDT over CHA in *** thickness was measured by OCT before,1,and 3 mo after *** choroidal thickness values of the fovea and CHAs were obtained for each *** outcomes were changes in the best-corrected visual acuity(BCVA)and amount of subretinal fluid(SRF).RESULTS:The differences in center choroidal thickness at baseline and at 1 and 3 mo post-PDT were statistically significant in group A and all patients(both P<0.001).There was no significant difference in group B(P=0.059).The differences of thickness of CHA and BCVA at baseline and1 and 3 mo post-PDT were statistically significant in group A,group B,and all patients(all P<0.01).All patients showed complete SRF absorption at 3 mo ***:Center choroidal thickness does not accurately reflect changes in CHA of patients whose CHA does not covered the fovea *** CHA as the observation target can make up for this limitation,expand the scope of application,and reduce bias.

关键词： central serous chorioretinopathy choroidal hyperpermeability choroidal thickness indocyanine green angiography optical coherence tomography

Intravitreal bevacizumab injection for chronic central serous chorioretinopathy

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Chinese Medical Journal 2010年第15期123卷 2145-2147页

作者： LI Xiu-juan ZHANG Jin-song Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China

central serous chorioretinopathy （CSC） is characterized by an idiopathic serous neurosensory detachment primarily affecting the *** most cases,the disorder is self-limited and spontaneously in 4 to 6 months, and the... 详细信息

关键词： central serous chorioretinopathy intravitreal bevacizumab retinal pigment epithelium detachment

Comprehensive evaluation of intravitreal conbercept versus half-dose photodynamic therapy for chronic central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 719-724页

作者： Jian-Bo Mao Cai-Yun Zhang Chen-Yi Liu Yun Zhang Jing-Jing Lin Zhao-Kai Xu Yi-Qi Chen Yuan-Yuan Fan Shi-Xin Zhao Li-Jun Shen Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Chicago College of Optometry Midwestern UniversityDowners GroveIL 60515USA

AIM:To compare the safety and efficacy of conbercept intravitreal injection and half-dose photodynamic therapy(PDT)in treating chronic central serous chorioretinopathy(CSC).METHODS:This study was ***-seven patients(37 eyes)with chronic CSC received conbercept injections while 57 patients(57 eyes)were treated with half-dose *** subjects were followed in *** measures included change in best-corrected visual acuity(BCVA),central macular thickness(CMT),subfoveal choroidal thickness(SFCT),and resolution of subretinal fluid(SRF).RESULTS:There was no adverse event observed in either treatment *** the 6-month follow-up,26 eyes(70.3%)in the conbercept group and 54 eyes(94.7%)in the half-dose PDT group(P0.05).The SFCT also improved in all subjects(P<0.001)with better outcome in the half-dose PDT group(P<0.05).CONCLUSION:Both intravitreal conbercept and halfdose PDT are safe to use in treating chronic *** 6mo,both treatment groups are efficacious in improving BCVA,reducing CMT and SFCT,and resolving SRF in eyes with chronic ***-dose PDT may show better outcome at initial phase of treatment in chronic *** follow-up period is necessary to study for long-term effect and safety.

关键词： central serous chorioretinopathy conbercept photodynamic therapy subfoveal choroidal thickness

A novel mutation of SGK-1 gene in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 23-28页

作者： Mahmut Akyol Muhammet Kazιm Erol Ozdemir Ozdemir Deniz Turgut Coban Ahmet Burak Bilgin Esin Sogutlu Sari Elif Betul Turkoglu Department of Medical Biology and Genetics Akdeniz University Faculty of Medicine Department of Ophthalmology Antalya Education and Research Hospital Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Akdeniz University Faculty of Medicine Department of Ophthalmology Balιkesir University Faculty of Medicine

AIM: To investigate the association of serum glucocorticoid kinase gene-1(SGK-1) DNA variants with chronic central serous chorioretinopathy(CSC).METHODS: We enrolled 32 eyes of 32 patients who were diagnosed with chronic CSC and composed 32 normal eyes as a control group. Peripheral blood was used for DNA extraction and polymerase chain reaction amplification. SGK1 gene was sequenced by using Big Dye Terminator v3.1 cycle sequencing Kit(Applied Biosystems, Foster City, CA, USA). The SGK-1 gene and its variants were investigated in CSC patient group and control ***: We identified a new polymorphism M32 V in two person in the patient group [Minor allele frequency(MAF) =0.009] on the region of 1-60 amino acids. The rs1057293 was located in the encoder region of the SGK- 1 gene but not associated with CSC(P =0.68). An intrinsic rs1743966 is also not associated(P =0.28).CONCLUSION: The new polymorphism M32 V is located on the region of 1-60 amino acids which is necessary for localization to the mitochondria in CSC patient. This mutation is probably important for the energy metabolism and plays an important role in the cellular response to hyperosmotic stress and other stress stimuli. Both rs1057293 and rs1743966 are not associated with CSC.

关键词： central serous chorioretinopathy mutation polymerase chain reaction serum glucocorticoid kinase gene-1

Clinical research of fenofibrate and spironolactone for acute central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1444-1450页

作者： Yong Chai Rong-Qiang Liu Jing-Lin Yi Ling-Hong Ye Jing Zou Nan Jiang Yi Shao Department of Ophthalmology the First Affiliated Hosptal of Nanchang University Jiangxi Province Clinical Ophthalmology Institute Nanchang 330006 Jiangxi Province China Affiliated Eye Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Postgraduate College the Third hospital Affiliated of Sun Yat-sen University Guangzhou 510000 Guangdong ProvinceChina

AIM：To compare the effectiveness of combined fenofibrate and spironolactone with fenofibrate alone for treatment of central serous chorioretinopathy（CSCR）.METHODS： Totally 60 patients（60 eyes） with a history of acute CSCR were randomed into two groups： group A with combination of fenofibrate（200 mg） and spironolactone（100 mg）,and group B with only fenofibrate（200 mg）.They were taken half an hour before meals and once per day for *** changes of the visual acuity,subjective symptom,ocular surface disease index（OSDI）,the tear film and optical coherence tomography were observed at 2,4,6,and 8wk before and after ***： The best corrected visual acuity（BCVA,log MAR） was improved to 0.22 and 0.27 after treatment from baseline of 0.35 and 0.36 in groups A and B（P 〈0.05）,*** 8wk treatment,the central subfield thickness（CST）,and subretinal fluid volumn（SFV） decreased significantly to 49.5% and 78.8% in group A,37.0% and 57.2% in group *** were significant differences of CST and SFV in both groups（all P 〈0.05）.CONCLUSION：Fenofibratecombinedwithspironolactone may have more clinical efficacy in the treatment of CSCR than fenofibrate only.

关键词： fenofibrate spironolactone central serous chorioretinopathy vision optical coherence tomography

Efficacy of the subthreshold micropulse yellow wavelength laser photostimulation in the treatment of chronic central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1404-1410页

作者： Mehmed Ugur Isιk Mehmet Fatih Kagan Degirmenci Ayhan Saglιk Department of Ophthalmology Kastamonu University Faculty of MedicineKastamonu 37100Turkey Department of Ophthalmology CanklrlState HospitalCankin 18800Turkey Department of Ophthalmology Harran University Faculty of MedicineSanllurfa 63000Turkey

AIM:To evaluate the efficacy and safety of subthreshold micropulse yellow laser(SMYL)in the treatment of chronic central serous chorioretinopathy(CCSC).METHODS:The medical records of 58 eyes of 58 patients with CCSC were reviewed.A 577-nm SMYL system was used for the *** fluorescein angiography was used as the primary method of identifying CCSC,and resolution of subretinal fluid(SRF)evaluated by optical coherence tomography(OCT)and fundus *** macular thickness(CMT),central macular volume(CMV),total macular volume(TMV),subfoveal choroidal thickness(SFCT),subretinal fluid height(SRFH),and subfoveal fluid basement diameter values were measured by spectral domain-OCT(SD-OCT)for all ***:The mean age of the patients was 42.4±9.9(range:20-72)*** mean follow-up was 11.4±8.5(range:6-37)*** BCVA at at the final follow up after treatment was statistically significant from the *** SRF resolution was 12.1%of the eyes in the 1^st month,67.2%of the eyes in the 3rd month and 67.2%of the eyes in the last follow *** initial median CMT,CMV,TMV,and SFCT values before treatment was significantly higher than 3^rd month visit values(P<0.001).In the multivariate analysis performed,age and disease duration were found to be a risk factor for persistent SRF(P=0.017,P=0.016,respectively).CONCLUSION:SMYL treatment provides a significant anatomical and functional improvement and is effective in eliminating SRF in eyes with CCSC.

关键词： central serous chorioretinopathy subthreshold micropulse laser optical coherence tomography