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A novel mouse model of central cord syndrome

Neural Regeneration Research 2023年第12期18卷 2751-2756页

作者： Elzat Elham-Yilizati Yilihamu Xiangchuang Fan Zimeng Yang Shiqing Feng Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina Department of Orthopedics Tianjin Medical University General HospitalTianjinChina

Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we established a mouse model of acute blunt traumatic spinal cord injury by compressing the C6 spinal cord with 5 and 10 g/mm~2 compression weights to simulate cervical central cord syndrome.Behavioral testing confirmed that this model exhibited the characteristics of central cord syndrome because motor function in the front paws was impaired,whereas basic motor and sensory functions of the lower extremities were retained.Hematoxylin-eosin staining showed that the diseased region of the spinal cord in this mouse model was restricted to the gray matter of the central cord,whereas the white matter was rarely affected.Magnetic resonance imaging showed a hypointense signal in the lesion after mild and severe injury.In addition,immunofluorescence staining showed that the degree of nerve tract injury in the spinal cord white matter was mild,and that there was a chronic inflammation reaction.These findings suggest that this mouse model of central cord syndrome can be used as a model for preclinical research,and that gray matter is most vulnerable to injury in central cord syndrome,leading to impaired motor function.

关键词： animal model behavior central cord syndrome cervical spinal cord injury cervical spinal cord pathology preclinical research spinal cord spinal cord compression spinal cord injury

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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

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Frontiers of Medicine 2009年第1期3卷 45-48页

作者： Chengwei JING Qin FU Xiaojun XU Department of Orthopedics Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Orthopedics Shengjing Hospital of China Medical UniversityShenyang 110004China

This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome without radiographic spinal fracture-dislocation(CCSWORFD),retrospectively analyze the cases of CCSWORFD,and evaluate the curative effect of anterior cervical surgery methods for CCSWORFD.Twenty four cases of CCSWORFD(19 males and 5 females),all suffering from cervical hyperextension injury,between 45–68(average 59)years old,were operated on by anterior cervical surgery methods.Among these,18 cases had been followed up for 6–24(average 15)months;18 cases,who had anterior decompression and plateﬁxation with titanium mesh bone grafting or iliac bone grafting achieved reliable effects based on the Japanese Orthopedics Association(JOA)evaluation(improved scores of cases with titanium mesh bone grafting,t=2.800,P0.05).Most of these cases had degeneration of cervical vertebra.The decompression which relieves the oppression to the spinal cord can help lessen edema of the spinal cord,and earlyﬁxation for stability of cervical vertebra is better for the recovery of spinal cord injury.Anterior operation with titanium mesh bone grafting or iliac bone grafting are both reliable curative methods for CCSWORFD,and titanium mesh bone grafting can avoid the trauma of the supplying graft.Mesh bone grafting can also shorten hospital stay.

关键词： central cord syndrome decompression,surgi-cal titanium mesh

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