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Sirius Scheimpflug–Placido versus ultrasound pachymetry for central corneal thickness:meta-analysis

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Eye and Vision 2021年第4期8卷 36-46页

作者： Yili Jin Colm McAlinden Yong Sun Daizong Wen Yiran Wang Jinjin Yu Ke Feng Benhao Song Qinmei Wang Shihao Chen Jinhai Huang School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhouZhejiangChina Department of Ophthalmology Singleton HospitalSwansea Bay University Health BoardSwanseaUK Shenzhen Hospital of Integrated Traditional and Western Medicine ShenzhenChina Key Laboratory of Vision Science Ministry of Health P.R.ChinaWenzhouZhejiangChina Eye Hospital of Wenzhou Medical University 270 West Xueyuan RoadWenzhou 325027ZhejiangChina

Background:To compare the difference in central corneal thickness(CCT)measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer(Sirius,CSO,Italy)and ultrasound pachymetry(USP).Methods:A systematic literature search was conducted for relevant studies published on PubMed,Medline,EMBASE,and the Cochrane Library and *** from inception to August 1st,*** outcome measures were CCT measurements between Sirius and USP.A random effects model was used to pool CCT ***:A total of twelve studies involving 862 eyes were included in this *** meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different(P<0.0001).The mean difference between Sirius and USP was−11.26μm with a 95%confidence interval(CI)(−16.92μm,−5.60μm).The heterogeneity was I^(2)=60%(P=0.004).Conclusion:CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than ***,it may be argued that the mean difference of 11.26μm is not a clinically significant difference.

关键词： Meta-analysis central corneal thickness Scheimpflug-Placido topographer Ultrasound Pachymetry

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Effect of 2% fluorescein on Scheimpflug central corneal thickness measurements

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 239-242页

作者： Stella Briggs Marwa Bin Moammar College of Applied Medical Sciences King Saud UniversityRiyadh 11433 Saudi Arabia Ophthalmology Clinic Security Forces Hospital Riyadh 11481 Saudi Arabia

AIM： To assess central corneal thickness （CCT） changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS： This was a prospective randomized study of 60 hospital volunteers. After baseline CCT measurements of both eyes of 40 subjects were obtained using Scheimpflug system, a drop of preservative-free 2% fluorescein, was instilled in one eye and in other eye, one drop of normal saline （control）. Measurements were repeated after 1, 2, 5, 10, 20, 30, 40, 50 and 60min （continuous assessment group）. Twenty subjects had baseline CCT taken, then fluorescein was instilled in one eye and measurements were taken at lmin. Ten eyes had saline rinse after lmin and 10 other eyes did not, measurements were repeated at 2min （eye rinse group）. RESULTS： The mean baseline CCT for continuous assessment group was 546.2±32.1um （range, 489.0-606.0）, control eyes was 546.6~±30.7 um （range, 489.0-602.0）. At lmin after fluorescein instillation, CCT significantly increased by 37.0±34.0um （P〈0.001）, then decreased gradually, reaching baseline at 60min. CCT variations were not significant in control group （P〉0.05）. For eye rinse group, CCT mean differences between baseline and 2min were 18.2um （95 % Ch -54.7 to 18.3） with rinse and 26.5um （95% CI： -62.9 to 9.9） without rinse; paired sample tests were not significant （P〉0.05）. CONCLUSION： The presence of fluorescein increased CCT value to a clinically relevant level of 6.8%. Eye rinse did not significantly reduce the effect at 2min post fluorescein timepoint.

关键词： central corneal thickness fluorescein Scheimpflug device

Changes in intraocular pressure and central corneal thickness during pregnancy:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1573-1579页

作者： Chao Wang Ai-Ling Li Yu Pang Ying-Qing Lei Ling Yu Department of Ophthalmology the Affiliated Hospital of Southwest Medical University Department of the School of Public Health of Southwest Medical University

AIM：To conduct a Meta-analysis for investigating the variations in intraocular pressure（IOP）and central corneal thickness（CCT）during normal ***：We searched for clinical trials published up to November 2015 without language or region restrictions in Pub Med,EMBASE,Web of Science,the Cochrane central Register of Controlled Trials,Ovid,EBSCO,Elsevier,the Chinese Biomedicine Database,Wan Fang,CNKI,CQVIP and Google *** of the ocular changes observed in pregnant women were *** main outcomes were assessed by changes in IOP and ***：Fifteen studies were *** subgroup analyses,IOP was significantly decreased during the second MD=-1.53,95%CI（-2.19,-0.87）;P〈0.00001,and third MD=-2.91,95%CI（-3.74,-2.08）;P〈0.00001 trimesters of *** was increased during the second MD=10.12,95%CI（2.01,18.22）;P=0.01,trimester of pregnancy;moreover,during the third trimester of pregnancy,the CCT displayed an increasing trend,but the difference was not significant MD=5.98,95%CI（-1.11,13.07）;P=***：A decrease in IOP is accompanied by an increase in CCT in the second and third trimesters of a normal pregnancy in women.

关键词： intraocular pressure central corneal thickness pregnancy Meta-analysis

Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 302-308页

作者： Hasan Ali Bayhan Seray Aslan Bayhan Iz.zet Can Department of Ophthalmology Bozok University Faculty of Medicine

AIM:To compare the RTVue spectral optical coherence tomography(SD-OCT),Sirius Scheimpflug-Placido topographer,Lenstar optical low coherence reflectometry(OLCR)and ultrasound pachymetry(USP)devices in terms of their agreement and repeatability of measuring central corneal thickness(CCT).METHODS:In this prospective study,50 eyes of 50patients were *** repeated measures were obtained using SD-OCT,Scheimpflug-Placido topographer and USP and five measurements were determined with the ***-Altman plots were used to assess agreement among the instruments,and 95%limits of agreement(LoA)for each comparison were ***-examiner repeatability was assessed using intraclass correlation coefficients(ICCs).RESULTS:The mean CCT by SD-OCT,ScheimpflugPlacido topographer,OLCR,and USP were 525.90±34.08μm,525.92±34.10μm,530.30±35.62μm,and543.50±37.11μm *** 4 modalities of CCT measurements correlated closely with each other,with Pearson correlation coefficients ranging from 0.977 *** mean differences(and upper/lower LoA)for CCT measurements were-0.05±6.77μm(13.3/-13.3)between SD-OCT and Scheimpflug-Placido topographer,4.38±3.79μm(11.8/-3.1)between OLCR and SD-OCT,4.38±6.03μm(16.2/-7.5)between OLCR and ScheimpflugPlacido topographer,13.20±6.46μm(25.9/0.5)between USP and OLCR,17.59±6.76μm(30.8/4.3)between USP and SD-OCT,and 17.58±8.13μm(33.5/1.6)between USP and Scheimpflug-Placido ***-examiner repeatability was excellent for all devices with ICCs>***:For most practical purposes,CCT measurements with the RTVue,Sirius and Lenstar can be used *** highly correlated,CCTmeasurement differences between USP and these 3optical instruments can be significant depending on the clinical situation.

关键词： central corneal thickness optical low coherence reflectometry spectral optical coherence tomography Scheimpflug-Placido topographer

corneal endothelial cell density and morphology and central corneal thickness in Guangxi Maonan and Han adolescent students of China

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 608-611页

作者： Hao Liang Hui-Yi Zuo Jin-Mao Chen Jie Cai Yu-Zhua Qin Yu-Ping Huang Ying-Ying Chen Dong-Yong Tang Shao-Jian Tan Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical University People's Hospital of Huanjiang Maonan Autonomous County

AIM: To investigate the corneal endothelial cell density and morphology and central corneal thickness in the Guangxi Maonan and Han adolescent students of ***: Noncontact specular microscope(Topcon SP3000 P, Tokyo, Japan) was performed in 133 adolescent students of Maonan nationality(M:F 54:79)and 105 adolescent students of Han nationality(M:F 50:55),5 to 20 y of age, who were randomly selected from 3schools in Huanjiang Maonan Autonomous County of Guangxi Zhuang Autonomous Region of *** studied included endothelial cell density,mean cell area, coefficient of variation in cell size,percentage hexagonality and central corneal thickness. RESULTS: Endothelial cell density, mean cell area,coefficient of variation in cell size, percentage hexagonality and central corneal thickness in the study population were(2969.50 ±253.93) cells/mm2,(339.23 ±29.44) μm2,(29.96 ±4.07) %,(64.58 ±9.41) % and(523.71 ±32.82) μm in Maonan and(2998.26 ±262.65) cells/mm2,(336.11±30.07) μm2,(29.89±5.03) %,(64.91±11.64) % and(524.39 ±33.15) μm in Han, respectively. No significant differences were observed in endothelial cell density,mean cell area, coefficient of variation in cell size,percentage hexagonality and central corneal thickness between Maonan and Han(P =0.615, 0.659, 0.528, 0.551,0.999). In Maonan and Han, we found age was negatively correlated with endothelial cell density and percentagehexagonality and positively correlated with mean cell area and coefficient of variation in cell size. Negative correlation was also found between central corneal thickness and age in Han, whereas no correlation was found in Maonan. CONCLUSION: There were no differences between Maonan and Han in corneal endothelial cell density and morphology and central corneal thickness. In these two nationalities, there were statistically significant decrease in endothelial cell density and percentage hexagonality with increasing age and statistically significant increase in cell area and coef

关键词： endothelial cell density morphology central corneal thickness Maonan

Effect of silicone oil removal on central corneal thickness

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 374-376页

作者： Gul Arikan Zeynep Ozbek F Hakan Oner Ismet Durak A Osman Saatci Department of Ophthalmology Dokuz Eylul UniversityIzmirTurkey

AIM:To evaluate the effect of silicone oil removal(SOR) on central corneal thickness(CCT) in aphakic and pseudophakic eyes prospectively.· METHODS:Patients who underwent SOR surgery between June 2005-August 2007 were included in this *** oil was actively removed behind the posterior capsule through the pars plana sclerotomy site(posterior approach) in pseudophakic eyes and through the pupil and the corneal tunnel incision(anterior approach) in aphakic eyes with the 18-gauge *** was assessed with Orbscan II corneal topography system preoperatively and at one month and three months postoperatively.A total of 34 eyes of 34 patients(26 males,8 females) comprised the study *** age was(55.6±12.3) years(Range:25-80 years).Twenty-six eyes(76.5%) were pseudophakic and 8(23.5%) *** time between silicone oil injection and removal was(15.1±13.6) months(Range:5-54 months).At baseline,CCT was 576.4±46.0μm in pseudophakic eyes and 611.6±36.2μm in aphakic eyes.· RESULTS:At the first postoperative month CCT was(573.3±40.1)μm and(630.9±72.9)μm in pseudophakic and aphakic eyes *** the third postoperative month,CCT was(582.7±49.5)μm and(614.5±82.4)μm in pseudophakic and aphakic eyes *** was no statistically significant difference in CCT measurements one month and 3 months after SOR when compared to preoperative values in both aphakic and pseudophakic eyes(P> 0.05).· CONCLUSION:Active SOR either by anterior or posterior approach did not affect the CCT.·

关键词： Aphakia central corneal thickness silicone oil pseudophakia

Measurement of central corneal thickness and precorneal tear film thickness of rabbits using the Scheimpflug system

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 584-587页

作者： Jing Dong Qiang Wu Xiao-Gang Wang Department of Ophthalmology the First Hospital of Shanxi Medical University Department of Ophthalmology the Sixth People's Hospital Affiliated to Shanghai Jiaotong University

AIMTo measure central corneal thickness (CCT) and pre-corneal tear film thickness using the Galilei dual-Scheimpflug analyzer (GSA) in New Zealand white rabbits.

关键词： tear film Scheimpflug rabbits central corneal thickness fluorescein

central corneal thickness in Adult Chinese

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第1期26卷 141-144页

作者：李鹏程胡燕华徐茜张光明麦才铿 Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology 430022 Wuhan China Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The central corneal thickness （CCT） in age 48 years or less of Chinese was characterized and its relationship with gender, age, refraction and intraocular pressure （IOP） was investigated. Right eyes of 1669 participants were included in this study （880 men, 52.7 % and 789 women, 47.3 %）. Mean age of the samples was 23.8±5.9 years. After the examination of corneal topography and refraction, Goldman applanation tonometry was carried out by one physician. Tonometric values were the mean of three consecutive readings. Subsequently, another physician carried out ultrasonic pachymetry with the DGH 2000 AP ultrasonic pachymeter. Six measurements were made at the center of the cornea of each eye. The mean value was used for analysis. The results showed that mean CCT of male participants was 551.33±34.62 μm, 5.79μm more than that of female participants. Linear regression analyses revealed that CCT was negatively related with age only in female and no association was found between refractive status and CCT. IOP was positively related to CCT, and there was a difference in IOP of 1.5 mmHg （1 mmHg=0. 133 kPa） per 100 μm difference in CCT. Ocular hypertension group was prone to have thicker cornea than average. The results indicated that in adult Chinese CCT tended to decrease with aging in female only. IOP measured by Goldmann tonometry was positively related with CCT so that CCT should be measured a- long with IOP.

关键词： central corneal thickness intraocular pressure gender age refraction

Changes of corneal central thickness of aphakia following congenital cataract surgery under the first six months of life

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 78-80页

作者： Wei Xiao Xiao-Fang Liang and Jia-Jun Sun Department of Ophthalmology Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China

AIM: To observe the central corneal thickness (CCT) changes in infants and young children who had been undergone bilateral congenital cataract surgery, and to compare the changes with normal control group which was selected from healthy population. METHODS: A cross section case-control study contained 28 cases (56 eyes) of bilateral aphakia (aphakic group) due to congenital cataract surgery combining with posterior continuous curvilinear capsulorhexis and with anterior vitrectomy during 2-6 months after birth. Fourteen children (28 eyes) of age-sex matched with the aphalic group were selected as normal control group. CCT and intraocular pressure (TOP) were measured postoperatively and the results were compared between groups. RESULTS: The mean CCT was 653.5 +/- 82.4 mu m in the aphakic group and 579.6 +/- 39.2 mu m in the control group, with a significant difference (P=0.000). The mean value of TOP in aphakic group (22.0 +/- 1.6mmHg) was greater than that of control group (16.9 +/- 2.1mmHg), P=0.023. There was a negative correlation between age and CCT in normal control group (r=-0.531, P=0.026), and there was no correlation in bilateral aphakia group (r=-0.324, P=0.165). CONCLUSION: Aphakic children due to congenital cataract surgery have a greater CCT than normal children. It is necessary to consider CCT in evaluating IOP for children after congenital cataract surgery.

关键词： congenital cataract surgery aphaka central corneal thickness introcular pressure