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Exosomes:emerging biomarkers unveiling cellular mysteries—a narrative review

Journal of Bio-X Research 2023年第3期6卷 104-115页

作者： Ijeoma Evangeline Umeche Mathew Folaranmi Olaniyan Department of Medical Laboratory Science Faculty of Applied Health SciencesEdo State University UzairueEdo StateNigeria

Exosomes have gained recognition as potential diagnostic and prognostic markers due to their stability and disease-specific ***,once dismissed as cellular debris,are now acknowledged as crucial mediators of intercellular communications and *** nanosized vesicles transport dynamic cargos consisting of bioactive molecules,including proteins,lipids,and nucleic acids,enabling cells to exchange information and influence each other’s *** review delves into the multifaceted roles of exosomes,particularly their emergence as biomarkers for various *** conduct research for this review,a comprehensive literature search strategy was employed across various databases using keywords related to exosomes,biomarkers,cellular communication,disease diagnosis,and *** articles were evaluated based on their relevance,and data were extracted,synthesized,and categorized according to thematic *** assessment was performed on different types of articles,ensuring robust *** cancer,exosomes act as liquid biopsy samples,revealing genetic mutations,and protein *** misfolded proteins characteristic of neurodegenerative diseases such as Alzheimer disease and Parkinson disease are carried by ***,exosomes have been studied as biomarkers for cardiovascular,infectious,and autoimmune *** addition to their functions as biomarkers,exosomes influence the tumor microenvironment,immune response,synaptic plasticity,and tissue *** remain to fill research gaps and standardize exosome *** are pivotal in intercellular communication and for disease diagnosis,offering insights into cellular processes,immunity,and *** research may reshape our understanding of cellular communication and drive therapeutic *** challenges must be addressed,exosomes hold undeniable potential for use in personalized medicine and biomedical research.

关键词： cellular mysteries emerging biomarkers exosomes narrative review

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