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Biological interaction and Imaging of Ultrasmall Gold Nanoparticles

Nano-Micro Letters 2024年第3期16卷 69-98页

作者： Dongmiao Sang Xiaoxi Luo Jinbin Liu Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

Ultrasmall gold nanoparticles(AuNPs)typically includes atomically precise gold nanoclusters(AuNCs)and AuNPs with a core size below 3 *** as a bridge between small molecules and traditional inorganic nanoparticles,the ultrasmall AuNPs show the unique advantages of both small molecules(e.g.,rapid distribution,renal clearance,low non-specific organ accumulation)and nanoparticles(e.g.,long blood circulation and enhanced permeability and retention effect).The emergence of ultrasmall AuNPs creates significant opportunities to address many challenges in the health field including disease diagnosis,monitoring and *** the nano–bio interaction dictates the overall biological applications of the ultrasmall AuNPs,this review elucidates the recent advances in the biological interactions and imaging of ultrasmall *** begin with the introduction of the factors that influence the cellular interactions of ultrasmall *** then discuss the organ interactions,especially focus on the interactions of the liver and *** further present the recent advances in the tumor interactions of ultrasmall *** addition,the imaging performance of the ultrasmall AuNPs is summarized and ***,we summarize this review and provide some perspective on the future research direction of the ultrasmall AuNPs,aiming to accelerate their clinical translation.

关键词： Ultrasmall gold nanoparticle cellular interaction Organ interaction Tumor interaction Bioimaging

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Intercellular Trogocytosis Plays an Important Role in Modulation of Immune Responses

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cellular & Molecular Immunology 2008年第4期5卷 261-269页

作者： Khawaja Ashfaque Ahmed Manjunatha Ankathatti Munegowda Jim Xiang Research Unit Saskatchewan Cancer AgencyDepartments of OncologyMicrobiology and ImmunologyCollege of MedicineUniversity of Saskatchewan20 Campus DriveSaskatoon Saskatchewan S7N 4H4Canada Research Unit Saskatchewan Cancer AgencyDepartments of OncologyMicrobiology and ImmunologyCollege of MedicineUniversity of Saskatchewan20 Campus Drive SaskatoonSaskatchewan S7N 4H4Canada

Intercellular communication is an important means of molecular information transfer through exchange of membrane proteins from cells to cells. Advent of the latest analytical and imaging tools has allowed us to enhance our understanding of the cellular communication through the intercellular exchange of intact membrane patches, also called trogocytosis, which is a ubiquitous phenomenon. Immune responses against pathogens or any foreign antigens require fine immune regulation, where cellular communications are mediated by either soluble or cell surface molecules. It has been demonstrated that the membrane molecule transfer between immune cells such as dendritic and T cells can be derived through internalization/recycling pathway, dissociation-associated pathway, uptake of exosomes and membrane nanotube formations. Recent evidence implicates the trogocytosis as an important mechanism of the immune system to modulate immune responses. Exchange of membrane molecules/ antigens between immune cells has been observed for a long time, but the mechanisms and functional consequences of these transfers remain unclear. In this review, we discuss the possible mechanisms of trogocytosis and its physiological relevance to immune system, with special reference to T cells and the stimulatory or suppressive immune responses derived from T cells with acquired dendritic cell membrane molecules. cellular ＆ Molecular Immunology. 2008;5（4）：261-269.

关键词： cellular interaction membrane molecule transfer CTL response immune suppression

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