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Liquid biopsy:expanding the frontier of circulating biomarker discovery and validation in breast cancer

Cancer Drug Resistance 2019年第4期2卷 1215-1223页

作者： Philip CMiller Dorraya El-Ashry Marc ELippman Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University School of MedicineWashington DCWA 20007USA Breast Cancer Research Foundation New YorkNY 10036USA Department of Laboratory Medicine and Pathology Masonic Cancer CenterUniversity of MinnesotaMinneapolisMN 55455USA

Liquid biopsies represent an attractive,minimally-invasive alternative to surgical sampling or complex imaging of breast cancer and breast cancer *** we present a summary of the major biomarker components often evaluated in liquid biopsy samples from patients with breast cancer,including circulating tumor cells,circulating cell-free tumor dna,and cancer-associated plasma *** discuss recent advancements in methods of detection and use of these biomarkers in breast ***,we highlight some of our own recent contributions to breast cancer liquid biopsy,including the identification and characterization of circulating Cancer Associated Fibroblasts.

关键词： Liquid biopsy breast cancer cell-free tumor dna CTC cancer associated fibroblast

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Circulating tumor dna for diagnosis,prognosis and treatment of gastrointestinal malignancies

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World Journal of Clinical Oncology 2022年第6期13卷 473-484页

作者： Patrick Kirchweger Helwig Valentin Wundsam Holger Rumpold Department of Surgery Ordensklinikum LinzLinz 4010Austria Gastrointestinal Cancer Center Ordensklinikum LinzLinz 4010Austria Medical Faculty JKU University LinzLinz 4040Austria

Minimally invasive detection of circulating tumor dna(ctdna)in peripheral blood or other body fluids of patients with gastrointestinal malignancies via liquid biopsy has emerged as a promising *** is urgently needed,as conventional imaging and plasma protein-derived biomarkers lack sensitivity and specificity in prognosis,early detection of relapse or treatment *** review summarizes the potential role of liquid biopsy in diagnosis,prognosis and treatment monitoring of gastrointestinal malignancies,including upper gastrointestinal,liver,bile duct,pancreatic and colorectal *** can now be part of the clinical routine as a promising,highly sensitive and specific biomarker with a broad range of ***-biopsy based postoperative relapse prediction could lead to improved survival by intensification of adjuvant treatment in patients identified to be at risk of early ***,ctdna allows monitoring of antineoplastic treatment success,with identification of potentially developed resistance or therapeutic targets during the course of *** may also assist in early change of chemotherapy in metastatic gastrointestinal malignancies prior to imaging findings of ***,clinical utility is dependent on the tumor’s entity and burden.

关键词： cell-free tumor dna Circulating tumor dna Gastrointestinal cancer Liquid biopsy Esophageal cancer Gastric cancer Liver cancer Bile duct cancer Pancreatic cancer Colorectal cancer

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