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Ectopic mineralization-inspired cell membrane-based matrix vesicle analogs for in-depth remineralization of dentinal tubules for treating dentin hypersensitivity

引用

Nano Research 2023年第5期16卷 7269-7279页

作者： Mingjing Li Xiaoran Zheng Zhiyun Dong Yuyue Zhang Wei Wu Xingyu Chen Chunmei Ding Jiaojiao Yang Jun Luo Jianshu Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing UniversityChongqing 400030China College of Medicine Southwest Jiaotong UniversityChengdu 610003China State Key Laboratory of Oral Diseases West China Hospital of Stomatology and Med-X Center for MaterialSichuan UniversityChengdu 610041China Med-X Center for Material Sichuan UniversityChengdu 610041China

The invasion of etched dentinal tubules(DTs)by external substances induces dentin hypersensitivity(DH).The deep and compact occlusion of DTs is highly desirable for treating DH but still challenging due to the limited penetrability and mineralization capacities of most current *** vesicles(MVs)participate in the regulation of ectopic ***,ectopic MV analogs are prepared by employing natural cell membranes to endow mineral precursors with natural biointerfaces and integrated biofunctions for stimulating dentin *** analogs quickly access DTs(>20μm)in only 5 min and further penetrate deep into the interior of DTs(an extraordinary~200μm)in 7 *** in vitro and in vivo studies confirm that the DTs are efficiently sealed by the newly formed minerals(>50μm)with excellent resistance to wear and acid erosion,which is significantly deeper than most reported *** repair,the microhardness of the damaged dentin can be recovered to those of healthy *** the first time,cell membrane coating nanotechnology is used as a facile and efficient therapy for in-depth remineralization of DTs in treating DH with thorough and long-term effects,which provides insights into their potential for hard tissue repair.

关键词： bioinspiration dentin remineralization cell membrane coating nanotechnology ectopic matrix vesicles mineral precursors

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