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A systematic study of the determinants of protein abundance memory in cell lineage

Science Bulletin 2018年第16期63卷 1051-1058页

作者： Zongmao Gao Haoyuan Sun Shanshan Qin Xiaojing Yang Chao Tang Center for Quantitative Biology Peking University Peking-Tsinghua Center for Life Sciences Peking University School of Physics Peking University

Proteins are essential players of life activities, lntraceUular protein levels directly affect cellular functions and cell fate. Upon cell division, the proteins in the mother cell are inherited by the daughters. However, what factors and by how much they affect this epigenetic inheritance of protein abundance remains unclear. Using both computational and experimental approaches, we systematically investigated this problem. We derived an analytical expression for the dependence of protein inheritance on various factors and showed that it agreed with numerical simulations of protein production and experimental results. Our work provides a framework for quantitative studies of protein inheritance and for the potential application of protein memory manipulation.

关键词： Protein abundance memory Intrinsic noise Extrinsic noise Epigenetic inheritance cell lineage

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lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies

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National Science Review 2017年第4期4卷 533-542页

作者： Guangdun Peng Patrick P.L.Tam Naihe Jing State Key Laboratory of cell Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of SciencesUniversity of Chinese Academy of Sciences Embryology Unit Children’s Medical Research Institute School of Medical SciencesSydney Medical School University of Sydney School of Life Science and Technology Shanghai Tech University

Establishment of progenitor cell populations and lineage diversity during embryogenesis and the differentiation of pluripotent stem cells is a fascinating and intricate biological process. Conceptually, an understanding of this developmental process provides a framework to integrate stem-cell pluripotency, cell competence and differentiating potential with the activity of extrinsic and intrinsic molecular *** recent advent of enabling technologies of high-resolution transcriptome analysis at the cellular,population and spatial levels proffers the capability of gaining deeper insights into the attributes of the gene regulatory network and molecular signaling in lineage specification and differentiation. In this review, we provide a snapshot of the emerging enabling genomic technologies that contribute to the study of development and stem-cell biology.

关键词： early development cell lineage cell identity scRNA-seq spatial transcriptome

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A self-activation loop maintains stem cell fate for branching

A self-activation loop maintains stem cell fate for branchin...

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2018全国植物生物学大会

作者： Xiuwei Cao Yuling Jiao State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Plants differ from most animals in their retained ability to initiate new cycles of growth and development,which relies on the establishment and activity of branch *** seed plants,branching is achieved by axillary meristems,which are established in the axil of each leaf base and develop into lateral *** meristems are initiated from a meristematic cell population originally detached from the shoot apical *** remains unclear how the meristematic cell fate is *** we show that the meristem marker gene SHOOT MERISTEMLESS(STM) can activates its own expression to enable cell fate ***,the self-activation loop requires an STM-interacting protein FEWER AXILLARY BRANCHING(FAB),whose mutants display compromised axillary bud *** and biochemical data suggest that the STM-FAB heterodimer binds and activates STM as well as additional axillary meristem regulatory *** together,our finding provides a striking example in which a self-activation loop maintains the meristematic cell fate to enable branching.

关键词： meristem stem cell cell lineage cell fate branching

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