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A focus on parietal cells as a renewing cell population

World Journal of Gastroenterology 2010年第5期16卷 538-546页

作者： Sherif M Karam Department of Anatomy Faculty of Medicine and Health Sciences United Arab Emirates University Al-Ain PO Box 17666 United Arab Emirates

The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells. The stem cells give rise to three main progenitors: prepit, preneck and preparietal cells. Parietal cells develop either directly from the noncycling preparietal cells or less commonly via differentiation of the cycling prepit and preneck cell progenitors. The formation of a parietal cell is a sequential process which involves diminishment of glycocalyx, production of cytoplasmic tubulovesicles, an increase in number and length of microvilli, an increase in number and size of mitochondria, and fi nally, expansion and invagination of the apical membrane with the formation of an intracellular canalicular system. Little is known about the genetic counterparts of these morphological events. However, the time dimension of parietal cell production and the consequences of its alteration on the biological features of the gastric gland are well documented. The production of a new parietal cell takes about 2 d. However, mature parietal cells have a long lifespan during which they migrate bidirectionally while their functional activity for acid secretion gradually diminishes. Following an average lifespan of about 54 d, in mice, old parietal cells undergo degeneration and elimination. Various approaches for genetic alteration of the development of parietal cells have provided evidence in support of their role as governors of the stem/progenitor cell proliferation and differentiation programs. Revealing the dynamic features and the various roles of parietal cells would help

关键词： cell differentiation cell dynamics cell renewal Oxyntic gland Oxyntic mucosa Parietal cell Preparietal cell

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A short review on cell-based biosensing:challenges and breakthroughs in biomedical analysis

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The Journal of Biomedical Research 2021年第4期35卷 255-263页

作者： Mihaela Gheorghiu Biosensors Department International Centre of BiodynamicsBucharest 060101Romania.

Current cell-based biosensors have progressed substantially from mere alternatives to molecular bioreceptors into enabling tools for interfacing molecular machineries and gene circuits with microelectronics and for developing groundbreaking sensing and theragnostic *** recent literature concerning whole-cell biosensors is reviewed with an emphasis on mammalian cells,and the challenges and breakthroughs brought along in biomedical analyses through novel biosensing concepts and the synthetic biology *** recent innovations allow development of cell-based biosensing platforms having tailored performances and capable to reach the levels of sensitivity,dynamic range,and stability suitable for high analytic/medical *** also pave the way for the construction of flexible biosensing platforms with utility across biological research and clinical *** work is intended to stimulate interest in generation of cell-based biosensors and improve their acceptance and exploitation.

关键词： biosensing electro-optical assays synthetic biology cell dynamics cell physiology theranostics

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