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Surface modification of three-dimensional Ca-P/PHBV nanocomposite scaffolds by physical entrapment of gelatin and its in vitro biological evaluation

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Frontiers of Materials Science 2011年第1期5卷 57-68页

作者： Bin DUAN Min WANG Zhao Yang LI Wai Chun CHAN William W. LU Department of Mechanical Engineering Faculty of Engineering The University of Hong Kong Pokfulam Road Hong Kong China Department of Orthopaedics and Traumatology Faculty of Medicine The University of Hong Kong Sassoon Road Hong Kong China

The properties of bone tissue engineering scaffolds such as architecture, porosity, mechanical properties and surface properties have significant effects on cellular response and play an important role in bone regeneration. In this study, threedimensional nanocomposite scaffolds consisting of calcium phosphate （Ca-P） nanoparticles and poly（hydroxybutyrate-co-hydroxyvalerate）（PHBV） copolymer with controlled external and internal architectures were successfully produced via selective laser sintering （SLS）, one of the versatile rapid prototyping techniques. The Ca-PIPHBV nanocomposite scaffolds had a porosity of （61.75±1.24）%, compressive strength of （2.16±0.21） MPa and Young＇s modulus of （26.98±2.29） MPa. The surface modification of scaffolds by gelatin was achieved through physical entrapment. The amount of entrapped gelatin could be controlled by varying the solvent composition and reaction time. The surface modification improved the hydrophilicity of scaffolds but did not significantly affect the surface morphology and mechanical properties. Osteoblast-like cells （SaOS-2） were cultured on scaffolds with and without gelatin surface modification. The majority of SaOS-2 cells were viable and proliferated in both types of scaffolds for up to 14 d in culture, as indicated by MTT assay and live and dead assay. Surface modification significantly increased cell proliferation for surface modified scaffolds, which could be due to the improvement in hydrophilicity of the scaffolds.

关键词： nanocomposite scaffold selective laser sintering surface modification physical entrapment cell behaviour

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cellular modulation by the mechanical cues from biomaterials for tissue engineering

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Biomaterials Translational 2021年第4期2卷 323-342页

作者： Qiang Wei Shenghao Wang Feng Han Huan Wang Weidong Zhang Qifan Yu Changjiang Liu Luguang Ding Jiayuan Wang Lili Yu Caihong Zhu Bin Li Department of Orthopaedic Surgery Orthopaedic InstituteThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu ProvinceChina China Orthopaedic Regenerative Medicine Group(CORMed) HangzhouZhejiang ProvinceChina

Mechanical cues from the extracellular matrix(ECM)microenvironment are known to be significant in modulating the fate of stem cells to guide developmental processes and maintain bodily *** engineering has provided a promising approach to the repair or regeneration of damaged *** are fundamental in cell-based regenerative *** artificial ECM that mimics the mechanical properties of native ECM would greatly help to guide cell functions and thus promote tissue *** this review,we introduce various mechanical cues provided by the ECM including elasticity,viscoelasticity,topography,and external stimuli,and their effects on cell ***,we discuss the underlying principles and strategies to develop natural or synthetic biomaterials with different mechanical properties for cellular modulation,and explore the mechanism by which the mechanical cues from biomaterials regulate cell function toward tissue *** also discuss the challenges in multimodal mechanical modulation of cell behaviours and the interplay between mechanical cues and other microenvironmental factors.

关键词： cell behaviour mechanical cues multi-modal stiffness viscoelasticity

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