检索结果-南通市图书馆

Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats

Neural Regeneration Research 2019年第6期14卷 1085-1090页

作者： Cheng-Cheng Ying Mei Yang Yong Wang Yong-Lian Guo Wan-Li Hu Xin-Min Zheng Department of Urology the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and Technology Department of Endocrinology Tongren Hospital of Wuhan University (Wuhan Third Hospital) Department of Urology Zhongnan Hospital of Wuhan University

Although the remaining nerve tissue can regenerate and partly restore erectile function when the cavernous nerve is compressed/severed and function lost, the limited regenerative ability of these nerve tissues often fails to meet clinical needs. Adipose-derived stem cells are easy to obtain and culture, and can differentiate into neural cells. Their proliferation rate is easy to control and they may be used to help restore injured cavernous nerve function. Sprague-Dawley male rats(n = 45) were equally randomized into three groups: fifteen rats as a sham-operated group, fifteen rats as a bilateral nerve crush(BINC) group(with no further intervention), fifteen rats as a BINC with intracavernous injection of one million neural-like cells from adipose-derived stem cells(NAS)(BINC + NAS) group. After 4 weeks, erectile function was assessed by stimulating the cavernous body. The number of myelinated axons in the dorsal cavernous nerve was determined by toluidine blue staining. The area of neuronal nitric oxide synthase-positive fibers in the dorsal penile nerve was measured by immunohistochemical staining. Masson staining was used to analyze the ratio of smooth muscle to collagen in penile tissue. The results demonstrate that maximal intracavernous pressure, the ratio of maximal intracavernous pressure to mean arterial pressure, the numbers of myelinated axons and neuronal nitric oxide synthase-positive fibers in the dorsal penile nerve, and the ratio of smooth muscle to collagen could be increased after cell transplantation. These findings indicate that neural-like cells from adipose-derived stem cells can effectively alleviate cavernous nerve injury and improve erectile function. All animal experiments were approved by the Animal Ethics Committee of Huazhong University of Science and Technology, China(approval No. 2017-1925) on September 15, 2017.

关键词： nerve regeneration adipose-derived neural stem cells corpus cavernosum cavernous nerve erectile dysfunction radical prostatectomy neurons cell differentiation neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury

引用

Neural Regeneration Research 2020年第1期15卷 120-127页

作者： Mei Yang Jiang-Yang Sun Cheng-Cheng Ying Yong Wang Yong-Lian Guo Department of Endocrinology Tongren Hospital of Wuhan University(Wuhan Third Hospital)WuhanHubei ProvinceChina Department of Hepatobiliary Surgery The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy.The recovery of erectile function following radical prostatectomy remains challenging.Our previous studies found that injecting adipose-derived stem cells(ADSCs)into the cavernosa could repair the damaged cavernous nerves,but the erectile function of the treated rats could not be restored to a normal level.We evaluated the efficacy of ADSCs infected with a lentiviral vector encoding rat brain-derived neurotrophic factor(lenti-rBDNF)in a rat model of cavernous nerve injury.The rats were equally and randomly divided into four groups.In the control group,bilateral cavernous nerves were isolated but not injured.In the bilateral cavernous nerve injury group,bilateral cavernous nerves were isolated and injured with a hemostat clamp for 2 minutes.In the ADSCGFP and ADSCrBDNF groups,after injury with a hemostat clamp for 2 minutes,rats were injected with ADSCs infected with lenti-GFP(1×106 in 20μL)and lenti-rBDNF(1×106 in 20μL),respectively.Erectile function was assessed 4 weeks after injury by measuring intracavernosal pressures.Then,penile tissues were collected for histological detection and western blot assay.Results demonstrated that compared with the bilateral cavernous nerve injury group,erectile function was significantly recovered in the ADSCGFP and ADSCrBDNF groups,and to a greater degree in the ADSCrBDNF group.Neuronal nitric oxide synthase content in the dorsal nerves and the ratio of smooth muscle/collagen were significantly higher in the ADSCrBDNF and ADSCGFP groups than in the bilateral cavernous nerve injury group.Neuronal nitric oxide synthase expression was obviously higher in the ADSCrBDNF group than in the ADSCGFP group.These findings confirm that intracavernous injection with ADSCs infected with lenti-rBDNF can effectively improve erectile dysfunction caused by cavernous nerve injury.This study was approved by the Medical Animal Care and Welfare Committee of Wuhan University,China(approval No.2017-1638)on

关键词： adipose-derived stem cells brain-derived neurotrophic factor cavernous nerve injury erectile dysfunction infection intracavernous injection lentiviral vector neuronal nitric oxide synthase radical prostatectomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cavernous brain malformations and their relation to black blood MRI in respect to vessel wall contrast enhancement

引用

Chinese Neurosurgical Journal 2018年第2期4卷 65-68页

作者： Athanasios K.Petridis Marian P.Suresh Jan F.Cornelius Richard Bostelmann Maxine Dibué-Adjei Lan Li Marcel A.Kamp Hans Jakob Steiger Bernd Turowski Rebecca May Department of Neurosurgery Heinrich Heine University DüsseldorfMoorenstr 540225 DüsseldorfGermany Diagnostic and Interventional Neuroradiology Heinrich Heine University DüsseldorfDüsseldorfGermany LivaNova Deutschland(a LivaNova PLC-owned subsidiary) Lindberghstr 2580939 MunichGermany

Background: Inflammatory responses are implicated as crucial patho-mechanisms of vascular brain malformations. Inflammation is suggested to be a key contributor to aneurysm rupture; however it is unclear whether inflammation contributes similarly to bleeding of cerebral cavernous malformations (CCMs). Black blood MRI is a sequence which identifies inflammation in blood vessel walls and in the present study is used to detect inflammatory response in CCMs. Methods: Fifteen patients with 17 CCMs treated in our department in 2017 were retrospectively analysed. All patients received black blood MRIs and the results were analysed in correlation with, size and bleeding of CCMs. Results: Size and bleeding status of CCMs did not correlate with contrast enhancement in the CCM wall. One of 3 patients with bleeding displayed contrast enhancement in black blood MRI, whereas the others had non enhancing lesions. Because of the small number of cases a statistical analysis was not performed. Conclusion: In this limited cohort, inflammatory reactions in CCMs could not be detected by black blood MRI suggesting that the level of inflammation is minimal in these lesions and those different patho-mechanisms play a more important role in the rupture of CCMs.

关键词： cavernous malformations Inflammation Black blood MRI

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Peritoneal cavernous hemangiomatosis:A case report

引用

World Journal of Clinical Cases 2019年第4期7卷 489-493页

作者： Li-Yuan Fu Hong-Yu Chen Xiao-Li Diao Zhen-Jun Wang Department of General Surgery Beijing Chaoyang Hospital Capital Medical University Department of Pathology Beijing Chaoyang Hospital Capital Medical University

BACKGROUND cavernous hemangiomatosis in the liver and spleen has been reported, but it occurs less commonly in the peritoneum. Here we report a case of peritoneal cavernous hemangiomatosis and share some valuable information about this disease.CASE SUMMARY A 57-year-old Chinese man had a huge abdominal mass with abdominal distention and a significant reduction of food consumption. An enhanced abdominal and pelvic computed tomography and positron emission tomography–computed tomography revealed multiple cystic masses on the peritoneum, greater omentum, small intestinal mesentery and the surface of the spleen, and a high maximum standardized uptake value of the largest cystic lesion. Exploratory laparotomy was performed, and multiple cystic masses were found on the surface of the peritoneum, greater omentum, mesentery of the small intestine, and surface of the liver and spleen. Dark red bloody cystic fluid was present in the cystic tumor. Pathological examination showed that in the stromal components, the irregular vascular wall was thin. The vessel lumen was interlinked, and the lumen was lined with flat endothelium. According to the intraoperative findings and pathologic results, the patient was diagnosed with peritoneal cavernous hemangiomatosis.CONCLUSION The possibility of peritoneal cavernous hemangiomatosis should be considered when multiple cystic masses are found in the abdominal cavity by preoperative examination.

关键词： Peritoneum Hemangiomatosis cavernous hemangiomatosis Cystic lesion Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluating the Tubridge? flow diverter for large cavernous carotid artery aneurysms

引用

中华神经外科杂志(英文) 2021年第1期07卷 36-42页

作者： Jia Luqiong Wang Jiejun Zhang Longhui Zhang Yunfeng You Wei Yang Xinjian Lv Ming Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tian Tan Hospital Capital Medical University Beijing 100070 China Department of Imaging and Nuclear Medicine Baoding No. 1 Central Hospital Baoding Hebei

Background: The Tubridge? flow diverter (TFD) was recently developed in China; however, its safety and efficacy in treating large cavernous carotid artery aneurysms (LCCAs) are unclear. Our objective was to evaluate the safety and efficacy of the TFD in patients receiving TFDs to treat LCCAs (10-25 mm).Methods: Between June 2013 and May 2014, seven patients with LCCAs were enrolled in our study, and all seven patients underwent TFD implantation combined with coils.Results: Angiographic follow-up images were available for all seven patients at a median of 57.5 ± 16.7 (range, 6-69) months. Seven patients obtained favorable angiographic results defined as O''Kelly-Marotta Scale C and D. Clinical follow-up data were available for all seven patients at a median of 73.32 ± 3.6 (range, 66-78) months. No patients developed new neurological deficits. Six patients achieved a modified Rankin scale score of 0, and diplopia improved in the remaining patient.Conclusions: The results were excellent for the aneurysms treated with TFDs in our patients with LCCAs. TFDs are feasible for the treatment of LCCAs, but a multicenter, controlled clinical trial is needed to evaluate the long-term safety and efficacy of the TFD to treat LCCAs.

关键词： Tubridge Flow diverter Aneurysm Large cavernous

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Spinal dumbbell-shaped epidural cavernous hemangioma (CM):report of nine surgical cases and literature review

引用

Chinese Neurosurgical Journal 2018年第1期4卷 26-32页

作者： Liang Zhang Zhifeng Zhang Wuyang Yang Jifeng Shang Wenqing Jia Jun Yang Yulun Xu Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityNo.6Tiantan XiliBeijingPeople's Republic of China Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Background:Spinal dumbbell-shaped epidural cavernous malformation (CM) is a rare, hypervascular entity frequently misdiagnosed for other lesions, leading to unexpected intraoperative bleeding and suboptimal resection. Our study aims to elucidate the demographics, management strategy, and outcome of this vascular disease.Methods:Retrospective review of patients seen in Beijing Tiantan Hospital with symptomatic dumbbell-shaped epidural CM from 2008 to 2013. All lesions were pathologically confirmed after resection. The clinical manifestations, radiographic features, and treatment modalities of these cases were analyzed.Results:We included 9 consecutive patients. Average age was 58 ± 12 years (range:34-79 years), with 66.7％male. Locations of the CMs were:thoracic (n=7, 77.8％), cervical (n=1, 11.1％), and cervicothoracic junction (n=1, 11.1％). Only one case presented with acute manifestations while others experienced chronic progressive spinal cord symptoms. The initial clinical diagnoses were:schwannoma (n=6, 66.7％), cavernous hemangioma (CM) (n=1, 11. 1％), meningioma (n=1, 11.1％), and angioma (n=1, 11.1％). Total resection was achieved in six patients (66.7％), and partial resection in the other three patients (33.3％). Average intraoperative blood loss was 400 ± 300 ml (range:100-1000 ml). During an average follow-up of 71 ± 21 months (range:29-94 months), excellent outcome was achieved in seven cases (77.8％), one partially improved (11.1％), and one deteriorated (11.1％). No patients experienced recurrence of symptoms.Conclusions:Spinal dumbbell-shaped epidural CM is a benign vascular malformation that should be differentiated from other dumbbell-shaped lesions. Accurate preoperative diagnose is challenging as no specific radiographic marker has been established. Total surgical resection should be recommended.

关键词： cavernous hemangiomas Spinal cord Epidural Dumbbell-shaped Imaging features Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intraoperative MRI-assisted neuro-port surgery for the resection of cerebral intraparenchymal cavernous malformation

引用

Chinese Neurosurgical Journal 2019年第4期5卷 211-219页

作者： Min Zhao Changyu Lu Jianfeng Liang Yuanli Zhao Xiaolei Chen Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina

Background:Intraparenchymal cerebral cavernous malformation is difficult to localize intraoperatively with conventional frameless navigation due to the"brain shift"effect.We conducted this study to evaluate the efficacy and safety of intraoperative magnetic resonance image(iMRl)-assisted neuro-port surgery for the resection of cerebral intraparenchymal cavernous malformation.Methods:Between April 2016 and December 2017,54 consecutive patients with intraparenchymal cerebral cavernous malformation who get surgical treatment in our hospital were enrolled into this study.Twenty-one patients were treated using iMRI-assisted neuro-port surgery(experiment group),and 33 patients underwent treatment by conventional microsurgery(control group).The iMRI was used in all cases for the compensation of the"brain shift"effect and keeping the navigation system up-to-date.The surgical resection rate,the total operation time,and the preoperative and postoperative Karnofsky Performance Status(KPS)scores were determined to evaluate the operative procedures.Results:There were no significant differences between the two groups in mean age,gender ratio,and volume of lesions(P>0.05).For the experiment group,the average duration of the procedure was 188.8 min with total resection of the lesions achieved in all 21 cases.For the control group,the average duration of the procedure was 238.2 min with total resection of the lesions achieved in 25 of 33 cases.The differences in the average duration of the procedure and the number of totally resected lesions between the two groups were statistically significant(Pcavernous malformation surgery.The method provides high accuracy and efficiency for lesion targeting and permits excellent anatomic orientation.With the assistance o

关键词： Intraoperative magnetic resonance image cavernous malformation iMRI Neuro-port surgery Neuronavigation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of cavernous sinus dural arteriovenous fistula using different surgical approaches:Analysis of 32 consecutive cases

引用

Journal of Interventional Medicine 2019年第3期2卷 118-122页

作者： Bin Xu Ziliang Wang Weixing Bai Tianxiao Li Henan Provincial People’s Hospital Henan Cerebrovascular Disease HospitalPeople’s Hospital of Zhengzhou UniversityDepartment of InterventionZhengzhou CityHenan Province450003PR China

Objective:Transarterial and transvenous embolization methods are considered effective and safe approaches for the treatment of cavernous sinus dural arteriovenous fistula(CSDAVF).Here.,we report the angioarchitectural features and clinical outcomes of CSDAVF in patients treated with either the inferior arterial approach(IAA) or the inferior petrosal sinus approach(IPSA).Methods:The clinical data of 32 patients with CSDAVF treated at our institution from May 2008 to May 2014 were retrospectively analyzed.All patients underwent routine diagnostic digital subtraction angiography(DSA) before surgery.Embolization was performed using the IPSA through the internal jugular vein or IAA,based on angioarchitectural features.Results:Of the 32 patients with CSDAVF,24 underwent embolization treatment through the internal jugular veinIPSA and 8 patients underwent treatment through IAA.Nineteen patients in the IPSA group experienced mild headache,which improved after specific treatment.The immediate postembolization angiographic results revealed complete occlusion in 26 cases(18 IPSA and 8 IAA) and almost complete occlusion in 6 cases(IPSA).Complications that occurred during the procedure included abducens nerve palsy(n=1,IPSA) and prosopoplegia(n=1,IAA).One patient developed tinnitus,which was diagnosed as anterior cranial fossa new-onset dural arteriovenous fistula on DSA,whereas the symptoms of other patients all improved with no recurrence.Conclusions:On the basis of the angioarchitectural features of CSDAVF,IAA can be considered the primary treatment when the blood-supplying artery and fistula are relatively singular,and when the microcatheter can easily reach the fistula through the artery.The venous approach should be selected as the primary approach when the fistula is indistinguishable and blood is supplied by multiple arteries through small plexiform vessels.Choosing the optimal surgical approach may increase the success rate of intravascular CSDAVF surgery and may help avoid complications.

关键词： cavernous sinus Dural arteriovenous fistula Embolization Intravascular treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THE DIAGNOSIS OF MAGNETIC RESONANCE IMAGING FOR SPINAL cavernous ANGIOMAS

引用

Academic Journal of Xi'an Jiaotong University 2001年第2期13卷 145-147页

作者：同志勤白斌同志超牛凤枝赵京龙李毅傅建设 Imaging Center Second Hosp. Xi' an Jiaotong Univ. Xi' an 710004 China

Objective To assess the characteristics of magnetic resonance imaging for spinal cavernous angiomas.Methods The examinations of plain scan and contrast enhanced scan of magnetic resonance were performed in three patients with spinal cavernous angiomas.Results The focus of two cases was located in thorax segment of the spinal cord and one in lower cervical segment.All focuses were single and the shape of spinal cord was normal or slightly thick. MRI characteristic of spinal cavernous angiomas was just like popcorn or mulberry with a jumbled gobbet signal. Low and short T 2 signal appeared around the focus. In all cases, there were no obvious contrast enhanced signal in 2 cases and one case with moderate contrast enhanced signal. The diameter of hemorrhage was smaller than that of the spinal cord.Conclusion MRI has higher sensitivity and specificity in the diagnosis of spinal cavernous angioma.

关键词： angioma cavernous spinal tumor magnetic resonance imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ENDOVASCULAR EMBOLIZATION TO TREAT CAROTID cavernous FISTULAE

引用

中华创伤杂志 1997年第3期13卷 82-84页

作者：李宝民张纪周定标孟祥辉段国升解放军总医院北京

ＥＮＤＯＶＡＳＣＵＬＡＲＥＭＢＯＬＩＺＡＴＩＯＮＴＯＴＲＥＡＴＣＡＲＯＴＩＤＣＡＶ┐ＥＲＮＯＵＳＦＩＳＴＵＬＡＥＬＩＢａｏ－ｍｉｎ（李宝民），ＺＨＡＮＧＪｉ（张纪），ＺＨＯＵＤｉｎｇ－ｂｉａｏ（周定标），ＭＥＮＧＸｉ... 详细信息

ＥＮＤＯＶＡＳＣＵＬＡＲＥＭＢＯＬＩＺＡＴＩＯＮＴＯＴＲＥＡＴＣＡＲＯＴＩＤＣＡＶ┐ＥＲＮＯＵＳＦＩＳＴＵＬＡＥＬＩＢａｏ－ｍｉｎ（李宝民），ＺＨＡＮＧＪｉ（张纪），ＺＨＯＵＤｉｎｇ－ｂｉａｏ（周定标），ＭＥＮＧＸｉａｎｇ－ｈｕｉ（孟祥辉），ＤＵＡＮ...

关键词：张纪 CAROTID cavernous EMBOLIZATION ENDOVASCULAR FISTULAE TO TREAT

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：