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casual associations between blood metabolites and colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue Hu Yi-Quan Cheng Zhi-Long Shi Fu-Peng Ren Gang-Feng Xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies casual

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casual Sex, Sex Work and Unprotected Sex among Men Who Have Sex with Men in the Human Papilloma Virus (HPV) Clinical Trial —North-West Region of Tshwane, South Africa

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World Journal of AIDS 2019年第4期9卷 167-182页

作者： Mildred R. Sebogodi Mmampedi Huma Mathilda M. Mokgatle Matsontso Peter Mathebula Maphoshane Nchabeleng Department of Epidemiology and Biostatistics School of Public Health Sefako Makgatho Health Sciences University Tshwane South Africa MECRU School of Medicine Sefako Makgatho Health Sciences University Tshwane South Africa Department of Microbiology School of Medicine Department of Microbiology Sefako Makgatho Health Sciences University Tshwane South Africa

Background: The gap in the understanding of the context of the sexually transmitted infections (STIs) and risky behaviours among men who have sex with men (MSM) could lead to the development and implementation of inappropriate interventions, which could exacerbate the rapid spread of STIs, especially HIV, among MSM. The aim of the study was to qualitatively assess the understanding of the STIs and the risky sexual behaviours of men who have sex with men in the North-West region of Tshwane. Methods: An exploratory qualitative design was employed to assess the STIs and the risky sexual behaviour of the MSM population. The study participants were enrolled in an HPV clinical trial at MECRU, which is a clinical research unit at the Sefako Makgatho Health Sciences University. Data collection occurred from September 2016 to May 2017. A convenience sampling method was used and n = 30 participants were selected. Face-to-face in-depth interviews were conducted on MSM 18 years and older, using a semi-structured interview guide. Thematic content analysis was used for data analysis, using NVivo version 10 software. Results: The mean age of the sample was 26 years, and the age range was 18 to 44 years. All were unmarried, and all of them came from townships, rural villages and informal settlements in the vicinity of the clinical research unit. The high-risk behaviours noted among the majority of the MSM in this study were having multiple sexual partners and exchanging partners, alcohol abuse, inconsistent condom-use, having unprotected anal sex, and having transactional sex. There was a high level of knowledge of STIs in the heterosexual population with poor understanding of STIs affecting MSM through anal sex. Most of the MSM played a female or bottom role, which made them vulnerable because they could not successfully negotiate condom use, and they reported that they sometimes accepted gifts or money in exchange for anal sex. Conclusion: The study concludes that the MSM in this

关键词： Men Who Have Sex with Men Sexually Transmitted Infections casual Sex Male Sex Work Condom Use

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A Comparative Analysis of casual Conversation and Institutional Talk

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疯狂英语（教师版） 2014年第1期 139-147页

作者：王柯芦乐山师范学院外国语学院四川乐山614000

This article reflects on the process of transcribing spoken interaction and makes a comparative analysis of two different varieties of spoken interaction(casual conver- sation and institutional talk). By doing so, it reveals how the different purposes of speech result in their distinctive characteristics, and shows how language is struc- tured to construct ideational meanings(Field) and interpersonal meanings(Tenor) that define each context.

关键词： transcription comparative analysis casual conversation institutional talk

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Store Environment:Its Importance and Consumers'Expectations on casual-wear Chain Stores in Honk Kong

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Journal of China Textile University(English Edition) 1999年第4期16卷 29-33页

作者：朱惠靖林美芝

This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-vironment for the casual-wear chain stores in *** Baker’s Three-category framework onstore environments namely ambient,design and socialfactors was adopted for *** results indi-cated that the store environment was important in affect-ing consumers’selection of store for *** alsorevealed that social factor was perceived relatively im-portant than ambient and design *** store ex-pectation dimensions were categorised and the resultdemonstrated that most respondents were concerned onthe social aspect in their expectation of having a satisfy-ing store environment.

关键词： Store environment casual - wear chain store fashion retailing Hong Kong

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前进的沙溪,盛名的休闲博览会：THE 8^TH CHINA＇S casual WEAR FAIR

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中国服装（北京） 2007年第8S期 17-17页

作者： Andi

2007年7月19日，第八届中国休闲服装博览会（CHCW2007）新闻发布会在北京新闻大厦隆重举行。会上宣布，由中国服装协会、中国服装设计师协会和中山市人民政府主办，广东省服装服饰行业协会、香港生产力促进局、香港贸易发展局与香港利... 详细信息

2007年7月19日，第八届中国休闲服装博览会（CHCW2007）新闻发布会在北京新闻大厦隆重举行。会上宣布，由中国服装协会、中国服装设计师协会和中山市人民政府主办，广东省服装服饰行业协会、香港生产力促进局、香港贸易发展局与香港利丰集团协办，及中山市沙溪镇人民政府、中山市经贸局承办的第八届中国休闲服装博览会（CHCW2007），将于10月26日～29日，在中国休闲服装名镇一广东省中山市沙溪镇星宝国际展览中心盛大开幕。

关键词：服装博览会休闲服装 casual 沙溪香港生产力促进局中国服装协会中国服装设计师协会香港贸易发展局

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休闲风格

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中国皮革 2010年第14期39卷 98-101页

作者：辑文

所谓的休闲，就是将彻底的放松进行到底．只要心情好，随意即可。休闲风格可以是奢华的代表．也可以只做简单的点缀．没有固定的模式。所以．不用刻意装饰．觉得舒服就好。许多鞋类品牌近几年都在往casual之余又Fashion的路线上走，女... 详细信息

所谓的休闲，就是将彻底的放松进行到底．只要心情好，随意即可。休闲风格可以是奢华的代表．也可以只做简单的点缀．没有固定的模式。所以．不用刻意装饰．觉得舒服就好。许多鞋类品牌近几年都在往casual之余又Fashion的路线上走，女鞋如此，男鞋更是有突出表现。

关键词：休闲风格 casual 点缀鞋类女鞋男鞋

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复杂系统建模的ε机理论方法及应用研究

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仪器仪表学报 2014年第8期35卷 1758-1765页

作者：张淑清李盼师荣艳翟欣沛姜兴广燕山大学电气工程学院河北省测试计量技术及仪器重点实验室秦皇岛066004

提出一种ε机理论发现复杂系统中隐含模式的新思路。该方法能在对系统内部结构无法知晓的情况下,不需要假设而根据系统自身的特性建模。先对时间序列进行符号化处理,生成符号序列。再采取因果态分割重构法重构ε机,重构后能够显示出原... 详细信息

提出一种ε机理论发现复杂系统中隐含模式的新思路。该方法能在对系统内部结构无法知晓的情况下,不需要假设而根据系统自身的特性建模。先对时间序列进行符号化处理,生成符号序列。再采取因果态分割重构法重构ε机,重构后能够显示出原始序列中的隐含信息。通过对工程中配电网系统故障选线的多组实验证明,4个评判指标:熵率、统计复杂度、状态数和相对熵率能够一致地显示出各条线路的隐含信息,在几个关键影响因素改变的情况下均能有效地区分故障线路和非故障线路。从而验证了ε机理论在复杂系统建模中的优越性,为复杂系统建模提供了一种有效途径,也为配电网故障选线提供了一种新的方法。

关键词：复杂系统建模 ε机重构符号化因果态分割重构故障选线 casual state splitting reconstruction (CSSR)

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Analysis and Causal Formulation Proof of an Optimal Iterative Learning Algorithm

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Intelligent Control and Automation 2010年第2期1卷 90-95页

作者： Vassiliki Vita Department of Electrical Engineering Educators

Iterative learning control (ILC) is used to control systems that operate in a repetitive mode, improving track-ing accuracy of the control by transferring data from one repetition of a task, to the next. In this paper an op-timal iterative learning algorithm for discrete linear systems is analyzed and a solution for its attainment is proposed. Finally the mathematical proof of the algorithm’s causal formulation is also provided in its com-plete form, since its implementation requires its causal formulation.

关键词： casual Formulation Discrete Systems Iterative Learning Control

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物理学咬文嚼字之六十一随机

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物理 2014年第3期43卷 204-212页

作者：曹则贤中国科学院物理研究所北京100190

随机性问题在数学和物理学中有着举足轻重的地位。涉及偶然性和概率的词汇包括probability,chance,possibility,randomness,stochastics,opportunity,haphazard,accidental,aleatory,casual,等等,汉语表述难免混乱不堪。量子力学的proba... 详细信息

关键词：物理学随机性经典概率论 casual 量子力学偶然性几率幅数学

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型动

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中国服装（北京） 2017年第7期 62-67页

2017年3月16日晚。以“型动（DYNAMIC OF FASHION）”为主题的casual Elite 2017秋冬时装发布会。联合集团旗下女装品牌LAURELINE、MASELEY、CONATUS于深圳华侨城洲际酒店时尚启幕。现场设计在“力量与律动”的平衡美学中，发掘当代女... 详细信息

2017年3月16日晚。以“型动（DYNAMIC OF FASHION）”为主题的casual Elite 2017秋冬时装发布会。联合集团旗下女装品牌LAURELINE、MASELEY、CONATUS于深圳华侨城洲际酒店时尚启幕。现场设计在“力量与律动”的平衡美学中，发掘当代女性的自信张力，诠释现代主义女性独立姿态。

关键词： casual Elite 时装发布会女装品牌联合集团现场设计现代主义华侨城

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