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Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury

引用

Neural Regeneration Research 2018年第7期13卷 1241-1246页

作者： Yan-Lei Wang Ying-Na Qi Wei Wang Chun-Ke Dong Ping Yi Feng Yang Xiang-Sheng Tang Ming-Sheng Tan Beijing University of Chinese Medicine Beijing China Department of spine Surgery China-Japan Friendship Hospital Beijing China

Decompression is the major therapeutic strategy for acute spinal cord injury,but there is some debate about the time window for decompression following spinal cord *** important goal and challenge in the treatment of spinal cord injury is inhibiting or reversing secondary *** Vessel electroacupuncture can improve symptoms of spinal cord injury by inhibiting cell apoptosis and improving the microenvironment of the injured spinal *** this study,Governor Vessel electroacupuncture combined with decompression at different time points was used to treat acute spinal cord *** rat models were established by inserting a balloon catheter into the atlanto-occipital *** upper cervical spinal cord was compressed for 12 or 48 hours prior to *** was conducted at the acupoints Dazhui（GV14） and Baihui（GV 20）（2 Hz,15 minutes） once a day for 14 consecutive *** with decompression alone,hind limb motor function recovery was superior after decompression for 12 and 48 hours combined with ***,the recovery of motor function was not significantly different at 14 days after treatment in rats receiving decompression for 12 ***-activating factor levels and caspase-9 protein expression were significantly reduced in rats receiving electroacupuncture compared with decompression *** findings indicate that compared with decompression alone,Governor Vessel electroacupuncture combined with delayed decompression（48 hours） is more effective in the treatment of upper cervical spinal cord *** Vessel electroacupuncture combined with early decompression（12 hours） can accelerate the recovery of nerve movement in rats with upper cervical spinal cord ***,further studies are necessary to confirm whether it is possible to obtain additional benefit compared with early decompression alone.

关键词： nerve regeneration acute spinal cord injury decompression Governor Vessel electroacupuncture platelet-activating factor apoptosis methylprednisolone caspase family upper cervical spine animal model Basso,Beattie and Bresnahan locomotor scale neural regeneration

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