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Genetic polymorphisms in pri-let-7a-2 are associated with ischemic stroke risk in a Chinese Han population from Liaoning, China: a case-control study

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Neural Regeneration Research 2021年第7期16卷 1302-1307页

作者： Yu-Ye Wang He-Yu Zhang Wen-Juan Jiang Fang Liu Lei Li Shu-Min Deng Zhi-Yi He Yan-Zhe Wang Department of Neurology Key Laboratory for Neurological Big Data of Liaoning ProvinceThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurology The First Affiliated HospitalSun Yat-sen University/Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological DiseasesNational Key Clinical Department and Key Discipline of NeurologyGuangzhouGuangdong ProvinceChina Department of Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoning ProvinceChina

Ischemic stroke is a complicated disease, and its pathogenesis has been attributed to the occurrence of genetic *** has suggested that the microRNA let-7a is involved in the pathogenesis of ischemic ***-miRNA is the primary transcript, which undergoes several processing steps to generate pre-miRNA and, later, mature *** this case-control study, we analyzed the distribution of prilet-7a-2 variants in patients at a high risk for ischemic stroke and the interactions of pri-let-7a-2 variants and environmental *** samples and clinical information were collected from 1086 patients with ischemic stroke and 836 healthy controls between December 2013 and December 2015 at the First Affiliated Hospital of China Medical *** found that the rs1143770 CC genotype and the C allele were associated with a decreased risk of ischemic stroke, whereas the rs629367 CC genotype was associated with an increased risk for ischemic ***, these two single-nucleotide polymorphisms were in linkage disequilibrium in this study *** analyzed gene-environment interactions and found that rs1143770 exerted a combined effect on the pathogenesis of ischemic stroke, together with alcohol use, smoking, and a history of ***, the detection of pri-let-7a-2 polymorphisms may increase the awareness of ischemic stroke *** study was approved by the Institutional Ethics Committee of the First Affiliated Hospital of China Medical University, China(approval No.2012-38-1) on February 20, 2012, and was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR-COC-17013559) on December 27, 2017.

关键词： case-control study Chinese Han population ischemic stroke pri-micro RNA pri-let-7a-2 risk factors rs1143770 rs629367 single-nucleotide polymorphism single-nucleotide polymorphism-environment interaction

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A case-control study on Children with Guillain-barre Syndrome in North China

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Biomedical and Environmental Sciences 2003年第2期16卷 105-111页

作者： GAI-FEN LIU ZHENG-LAI WU HU-SHENG WU QUAN-YI WANG GE-TU ZHAO-RI CHUN-YONG WANG ZHI-XUE LIANG SHU-LAN CUI JIAN-DE ZHENG CorrespondenceshouldbeaddressedtoGai-FenLIU PekingUnionMedicalCollegeandChineseAcademyofMedicalSciencesBeijing100005China

To explore the risk factors for Guillain-barre syndrome. Methods case-control study design was used in 51 cases of Guillain-barre syndrome,and 51 matched *** of the 51 cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C. jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using an ad hoc questionnaire, including his/her demographic information,onset of the illness, their personal hygiene and so on. Results The study showed that Guillain-barre syndrome was associated with a few factors, such as polio vaccine immunization before onset of illness (OR=7.27), no hand washing after defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with the illness (OR=9.5,P<0.001). Conclusion It is suggested that occurrence of Guillain-barre syndrome may correlate to infection of C. jejuni and poor personal hygiene in children.

关键词： Guillain-Barre syndrome (GBS) case-control study Campylobacter jejuni

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Driver Sleepiness and Risk of Car Crashes in Shenyang, a Chinese Northeastern City: Population-based case-control study

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Biomedical and Environmental Sciences 2003年第3期16卷 219-226页

作者： GAI-FENLIU SONGHAN DUO-HONGLIANG FENG-ZHIWANG XIN-ZHUSHI1 JIANYU ZHENG-LAIWU DepartmentofEpidemiology SchoolofBasicMedicinePekingUnionMedicalCollegeandChineseAcademyofMedicalSciencesBeijing100005China DepartmentofEpidemiology ShenyangMedicalCollegeShenyang110034LiaoningChina DepartmentofTrafficAccident ShenyangTrafficAdministrationShenyang110003LiaoningChina DepartmentofEpidemiology SchoolofBasicMedicinePekingUnionMedicalCollegeandInstituteofBasicMedicineChineseAcademyofMedicalSciencesBeijing100005China~

Objective To estimate the association of driver sleepiness with the risk of car crashes. Methods A population-based case-control study was conducted in Shenyang, a northeastern city in China, between November 2001 and July 2002. The case group comprised 406 car drivers involved in crashes, and 438 car drivers recruited at randomly selected sites, and on the day of week, and the time of day when they were driving on highways in the study region during the study period were used as control groups. Face-to-face interviews with drivers were conducted according to a well-structured questionnaire covering the circumstances of their current trip and their background information. Stanford sleepiness scale and Epworth sleepiness scale were used to quantify acute sleepiness and chronic sleepiness respectively. Results There was a strong association between chronic sleepiness and the risk of car crash. Significantly increased risk of crash was associated with drivers who identified themselves as sleepy (Epworth sleepiness score≥10 vs <10; adjusted odds ratio 2.07, 95% confidence interval 1.30 to 3.29), but no increased risk was associated with measures of acute sleepiness. Conclusions Chronic sleepiness in car drivers significantly increases the risk of car crash. Reductions in road traffic injuries may be achieved if fewer people drive when they are sleepy.

关键词： Driver sleepiness Car crash case-control study

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Facial dermatosis associated with Demodex:a case-control study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 1008-1015页

作者： Ya-e ZHAO Yan PENG Xiang-lan WANG Li-ping WU Mei WANG Hu-ling YAN Sheng-xiang XIAO Department of Immunology and Pathogen Biology Xi ＇an Jiaotong University College of Medicine Xi ＇an 710061 China Xi ＇an Center for Disease control and Prevention Xi ＇an 710054 China Department of Dermatology the Second Affiliated Hospital Xi ＇an Jiaotong University College of Medicine Xi ＇an 710004 China Department of Clinical Laboratory Chengdu First People＇s Hospital Chengdu 610041 China

Demodex has been considered to be related with multiple skin disorders,but controversy *** this case-control study,a survey was conducted with 860 dermatosis patients aged 12 to 84 years in Xi'an,China to identify the association between facial dermatosis and *** the patients,539 suffered from facial dermatosis and 321 suffered from non-facial *** mites were sampled and examined using the skin pressurization *** regression analysis was applied to analyze the association between facial dermatosis and Demodex infestation,and to identify the risk factors of Demodex *** results showed that total detection rate of Demodex was 43.0%.Patients aged above 30 years had higher odds of Demodex infestation than those under 30 *** to patients with neutral skin,patients with mixed,oily,or dry skin were more likely to be infested with Demodex(odds ratios(ORs) were 2.5,2.4,and 1.6,respectively).Moreover,Demodex infestation was found to be statistically associated with rosacea(OR=8.1),steroid-induced dermatitis(OR=2.7),seborrheic dermatitis(OR=2.2),and primary irritation dermatitis(OR=2.1).In particular,ORs calculated from the severe infestation(≥5 mites/cm2) rate were significantly higher than those of the total ***,we concluded that Demodex is associated with rosacea,steroid-induced dermatitis,seborrheic dermatitis,and primary irritation *** rate of severe infestation is found to be more correlated with various dermatosis than the total infestation *** risk factors of Demodex infestation,age,and skin types were *** study also suggested that good hygiene practice might reduce the chances of demodicosis and Demodex infestation.

关键词： Facial dermatosis Demodex infestation Association case-control study Age

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Having a Partner and Having Children:Comparisons of Adults with Congenital Heart Disease and the General Population:A 15-Year case-control study

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Congenital Heart Disease 2023年第3期18卷 337-348页

作者： Siegfried Geyer Claudia Dellas Thomas Paul Matthias Müller Kambiz Norozi Medical Sociology Unit Hannover Medical SchoolHannover30625Germany Department of Pediatric Cardiology Intensive Care Medicine and NeonatologyUniversity Medical Center GoettingenGoettingenGermany Department of Pediatrics Western UniversityLondonOntarioCanada Department of Pediatric Cardiology and Intensive Care Medicine Hannover Medical SchoolHannoverGermany

Objectives:To examine whether patients with congenital heart disease(CHD)are less likely to have a partner or children than individuals from the general ***:Longitudinal study with two assessments of the same patients(n=244)from a hospital population and controls(n=238)from the German Socio-Economic Panel(GSOEP)using parental education,patients age,and sex as matching *** first patient study was conducted between 5/2003 and 6/2004,the second one between 5/2017 and 4/*** were drawn from GSOEP-surveys 2004 and ***-severity was classified according to type of surgery:curative,reparative,or *** single was used as outcome measure,for offspring the outcome was having children or ***:Among women with CHD the rate of those living single was higher than among controls with the differences depending on disease complexity(curative:OR=5.5;reparative:OR=1.9;palliative:OR=2.7).No statistically significant differences between patients and controls emerged in the male study *** respect to children a marked difference emerged between women with CHD and *** patients the odds of having children were lower than among controls(curative:OR=0.3;reparative:OR=0.3;palliative:OR=0.2).The rate of patients with children with CHD(women:5.6%;men:4.9%)was higher than expected(1%)if compared with the general ***:Using partnership and children as outcome criteria,patients with CHD are disadvantaged if compared to subjects from the general *** female patients the social consequences of the disease turned out as more pervasive than in women.

关键词： Congenital heart disease children partnership panel study case-control study

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Relationship between self-reported residential indoor remodeling and semen quality： a case-control study

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Asian Journal of Andrology 2015年第6期17卷 981-984,I0009,I0010页

作者： Mao-Hua Miao Zheng Li De-Kun Li Bei Yan Hong Liang Er-Lei Zhi Hong-Wei Du Wei Yuan Department of Reproductive Epidemiology and Social Science National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices ShanghaiI~stitue of Planned Pa[enthood Rese.arch Shanghai China Department of Urology Shanghai Human Sperm Bank Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Division of Reseaich Kaiser Foundation Research Institute Kaiser Permanente Northern California CA USA.

The present study examined the association between residential indoor remodeling and poor semen quality. Sperm donors aged 18-45 years old were recruited in Shanghai, China. Semen specimens were collected and analyzed. An in-person interview was conducted to obtain information on the history of indoor remodeling and potential confounders. A total of 70 participants with abnormal semen quality （case group） and 68 controls were examined. A total of 20 subjects reported indoor remodeling in the recent 24 months, and among them 17 subjects reported indoor remodeling in the recent 12 months. Compared with participants with no history of indoor remodeling, participants with a history of indoor remodeling in the recent 24 months were more than three times as likely to have poor sperm quality （adjusted odds ratio = 3.8, 95% confidence interval： 1.3-12.0） after controlling for potential confounders. The association was strengthened when the analysis was restricted to those who had indoor remodeling in the recent 12 months. Our findings provide preliminary evidence that indoor remodeling has an adverse effect on semen quality.

关键词： case-control study chemicals health effect indoor remodeling semen quality

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Risk of Active Pulmonary Tuberculosis among Patients with Coal Workers'Pneumoconiosis:A case-control study in China

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Biomedical and Environmental Sciences 2018年第6期31卷 448-453页

作者： JIN Yan FAN Jing Guang PANG Jing WEN Ke ZHANG Pei Ying WANG Huan Qiang LI Tao National Institute of Occupational Health and Poison control Chinese Center for Disease Control and PreventionBeijing 100050China Department of Infectious Disease Taizhou Center for Disease Control and PreventionTaizhou 318000ZhejiangChina Research Center for Occupational Safety and Health State Administration of Work SafetyBeijing 102308China Department of Orthopedics and Chinese-Western Medicine Hunan Institute for Tuberculosis ControlChangsha 410013HunanChina

The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.

关键词： Pulmonary tuberculosis Coal workers' pneumoconiosis Risk case-control study

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Diagnostic value of interleukin-8 in colorectal cancer:A case-control study and meta-analysis

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World Journal of Gastroenterology 2014年第43期20卷 16334-16342页

作者： Wen-Jun Jin Jin-Ming Xu Wen-Li Xu Dong-Hua Gu Pei-Wei Li Department of Clinical Laboratory Huzhou Central Hospital Department of Epidemiology and Health Statistics Zhejiang University School of Public Health Department of Pathology Huzhou Central Hospital

AIM: To assess the diagnostic value of serum interleukin-8 (IL-8) in the detection of colorectal cancer (CRC).

关键词： Interleukin-8 Colorectal cancer Diagnostic value case-control study Meta-analysis

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Nutrient patterns and risk of cataract：a case-control study

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 586-592页

作者： Fatemeh Sedaghat Matin Ghanavati Parisa Nezhad Hajian Sara Hajishirazi Mehdi Ehteshami Bahram Rashidkhani Department of Community Nutrition Faculty of Nutrition Sciences and Food TechnologyNational Nutrition and Food Technology Research Institute (WHO Collaborating Center)Shahid Beheshti University of Medical Sciences

AIM：To assess the relation between nutrient patterns and cataract ***：This is a hospital-based case-control study with 97 cataract patients and 198 matched *** consumption was collected through a valid food frequency questionnaire（FFQ）.Nutrient patterns were detected by applying factor *** logistic regression models were used to estimate odds ratio（ORs） and 95%***：We extracted 5 main nutrient *** 1 included niacin,thiamin,carbohydrates,protein,zinc,vitamin B6 and sodium（sodium pattern）.Factor 2 was characterized by oleic acid,monounsaturated fats,polyunsaturated fats,linoleic acid,trans fatty acid,linolenic acid,vitamin E and saturated fats（fatty acid pattern）.The third factor represented high intake of vitamin B12,vitamin D,cholesterol and calcium（mixed pattern）.The 4^（th） pattern was high in intake of beta and alpha carotene,vitamin A and vitamin C（antioxidant pattern）.Finally,the 5^（th） pattern loaded heavily on docosahexaenoic acid（DHA） and eicosapentaenoic acid（EPA）（omega-3 pattern）.In crude and multivariate analysis,the sodium pattern was associated with increased risk of cataract（OR=1.97,95%CI：1.09-3.96）.The fatty acid pattern elevated the risk of cataract（OR=1.94,95%CI：1.1-3.86）.Antioxidant pattern was associated with a significant 79% reduced risk（2^（nd） category compared with the 1st）.Omega-3 pattern was significantly negatively associated with risk of cataract（P=0.04）.CONCLUSION：These findings imply that nutrient patterns reflecting a combined consumption of nutrients might be important in the etiology of *** studies with more efficient designs are warranted to confirm our findings.

关键词： nutrient patterns cataract case-control study

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Risk factors of intrahepatic cholangiocarcinoma in patients with hepatolithiasis:a case-control study

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 626-631页

作者： Zhen-Yu Liu,Yan-Ming Zhou,Le-Hua Shi and Zheng-Feng YinAuthor Affiliations:Molecular Oncology Laboratory and Department of Comprehensive Treatment I,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Department of Hepato-Biliary-Pancreato-Vascular Surgery,First Affiliated Hospital,Xiamen University,Xiamen 361003,China Molecular Oncology Laboratory Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Comprehensive Treatment I Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Hepato-Biliary-Pancreato-Vascular Surgery First Affliated Hospital Xiamen University Xiamen 361003 China

BACKGROUND:Why 3.3% to 10% of all patients with hepatolithiasis develop intrahepatic cholangiocarcinoma (ICC) remains *** carried out a hospital-based case-control study to identify risk factors for the development of ICC in patients with hepatolithiasis in ***:Eighty-seven patients with pathologically diagnosed hepatolithiasis associated with ICC and 228 with hepatolithiasis alone matched by sex,age (±2 years),hospital admittance and place of residence were interviewed during the period of *** ratios (OR) and 95% confidence intervals (CI) were calculated for each risk ***:Among the patients with hepatolithiasis associated with ICC,the mean age was 57.7 years and 61.0% were female Univariate analysis showed that the significant risk factors for ICC development in hepatolithiasis were smoking,family history of cancer,appendectomy during childhood (under age 20),and duration of symptoms >10 *** multivariate stepwise logistic regression analysis,smoking (OR=1.931,95% CI:1.000-3.731),family history of cancer (OR=5.175,95% CI:1.216-22.022),and duration of symptoms >10 years (OR=2.348 95% CI:1.394-3.952) were independent ***:Smoking,family history of cancer and duration of symptoms >10 years may be risk factors for ICC in patients with hepatolithiasis.

关键词： risk factors intrahepatic cholangiocarcinoma hepatolithiasis case-control study

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