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Proinflammatory Signaling cascades of Periodontopathic Oral Pathogen <i>Porphyromonas gingivalis</i>

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Journal of Biosciences and Medicines 2018年第5期6卷 63-88页

作者： Bronislaw L. Slomiany Amalia Slomiany Research Center Rutgers School of Dental Medicine Rutgers The State University of New Jersey Newark USA

Porphyromonas gingivalis, is the most prominent member of the bacteria flora associated with pathogenesis of periodontitis, a chronic inflammatory disease resulting in tooth loss. The extent of oral mucosal reaction to P. gingivalis invasion relays heavily on Toll-like receptors (TLRs) that recognize structurally common motifs of pathogens and initiate antibacterial responses. Among the virulence factors of P. gingivalis implicated in TLRs activation and triggering inflammatory responses leading to the development of periodontitis is the bacterium cell-wall lipopolysaccharide (LPS). The engagement by the LPS of oral mucosal TLR4 leads to initiation of signaling events characterized by the activation of mitogen-activated protein kinase (MAPK) and IκB-kinase complex (IKK) cascades, induction of phosphoinositide-specific phospholipase C (PLC)/protein kinase C (PKC)/PI3K pathway, up-regulation in TGF-α ectodomain shedding and EGFR transactivation, and the amplification of proinflammatory signals by spleen tyrosine kinase (Syk). These events, in turn, exert their control over transcription factors implicated in the induction of the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) genes that lead to up-regulation in the inflammatory mediators, PGE2 and NO. The systems involved in transcription factors activation, furthermore, remain under additional regulatory control through S-nitrosylation. Moreover, the LPS-induced TLR4 activation provides a docking site for Syk, the activation of which leads to amplification of the inflammatory signals by affecting transcription factors activation and their assembly to transcriptional complexes. Interestingly, the extent of oral mucosal inflammatory response to P. gingivalis remains under modulatory influence by two biologically active peptide hormones, leptin and ghrelin. Therefore, the presence of these multifunctional peptides in oral mucosa and saliva may be of significance in countering the destru

关键词： P. gingivalis Periodontal Disease Oral Mucosa Inflammatory Response LPS TLR4 Signaling cascades

cascades优化升级Wagram纸厂生活用纸加工线

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中华纸业 2018年第23期 76-76页

cascades宣布投资5800万美元对Wagram工厂的生活用纸加工线进行现代化改造升级,并将安装新的生活用纸加工设备。Wagram工厂主要加工PRO品牌手帕纸、厕纸和餐巾纸等,加工的生活用纸主要来自于Rockingham纸

关键词：生活用纸 Wagram cascades

cascades以2.07亿美元收购Orchids纸业公司

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造纸信息 2019年第9期 80-80页

作者：陈京环

7月2日,包装回收与制造以及生活用纸生产商cascades宣布,已就收购Orchids纸业公司的大部分资产事项达成最终协议,收购金额为2.07亿美元,交易计划于2019年8月或9月结束。目前Orchids纸业公司生活用纸原纸年产能为11.4万t,生活用纸加工能... 详细信息

7月2日,包装回收与制造以及生活用纸生产商cascades宣布,已就收购Orchids纸业公司的大部分资产事项达成最终协议,收购金额为2.07亿美元,交易计划于2019年8月或9月结束。目前Orchids纸业公司生活用纸原纸年产能为11.4万t,生活用纸加工能力11.4万t,过

关键词：纸业公司 Orchids cascades

cascades公司向Voith Paper公司订购技术装备

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造纸信息 2003年第10期 36-36页

作者：厂军

加拿大cascades公司关停美国缅因州的脱墨浆工厂

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中华纸业 2016年第13期37卷 80-80页

加拿大cascades Inc.公司近期宣布将永久性的关停其位于美国缅因州的脱墨浆工厂。据称该工厂的生产将在7月8日停止,而工厂将在7月15日关停。该工厂雇用员工约有45名。据cascades公司称,之所以关停此工厂,主要是印刷和书写纸市场的快速萎... 详细信息

加拿大cascades Inc.公司近期宣布将永久性的关停其位于美国缅因州的脱墨浆工厂。据称该工厂的生产将在7月8日停止,而工厂将在7月15日关停。该工厂雇用员工约有45名。据cascades公司称,之所以关停此工厂,主要是印刷和书写纸市场的快速萎缩,导致脱墨浆市场情况受到负面影响,

关键词：脱墨浆 cascades 美国缅因州书写纸

用远震P波残差法探测俄勒冈cascades地区的地热源

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地球物理学进展 1986年第1期 141-141页

作者： H.M.Iyer 葛叶阳

从构造沉降、年轻火山群的存在和高热流的观点来看,俄勒冈cascades地区具有较高的地热生产潜力。但是,用各种地球物理方法来提供大尺度地壳岩浆体存在的明确证据的努力失败了,这与美国西部某些其它流纹岩火山中心的情况不同。在Hood山和... 详细信息

从构造沉降、年轻火山群的存在和高热流的观点来看,俄勒冈cascades地区具有较高的地热生产潜力。但是,用各种地球物理方法来提供大尺度地壳岩浆体存在的明确证据的努力失败了,这与美国西部某些其它流纹岩火山中心的情况不同。在Hood山和Newberry火山进行的一些远震残差研究没有显示出在这些火山之下存在着可探测到的尺度的地壳岩浆囊

关键词：远震远地震残差剩余误差 cascades 热源俄勒冈美国

Simulation of radiation damages in molybdenum by combining molecular dynamics and OKMC

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Nuclear Science and Techniques 2017年第1期28卷 12-19页

作者： Gui-Yan Wu Neng-Wen Hu Hui-Qiu Deng Shi-Fang Xiao Wang-Yu Hu Department of Applied Physics School of Physics and Electronics Hunan University Changsha 410082 China Department of Materials Science and Engineering Hunan University Changsha 410082 China

In this paper,radiation defects in bcc molybdenum with the primary knock-on atom(PKA) energies of2-40 keV are simulated by the molecular *** binding energy of single point defect-to-defect clusters increases with the cluster *** stabiUty and mobility of point defects and defect clusters are *** interstitial-type clusters are found to be easily migrating along the direction with low barriers(0.01-0.10 eV).Then,the object kinetic Monte Carlo is used to gain insight into the long-term defect evolution in the *** simulation results indicate that Stage I almost occurs at annealing temperature of 100K,which corresponds to the correlated recombination resulting from the motion of small interstitial clusters(n ≤2).The formation of substage partly as result of the small vacancy clusters *** about 460 K,the Stage II starts because of uncorrected recombination due to an emitting mechanism of larger *** distribution of the clusters at the cascade quenching stage is positively correlated with the PKA energies,affecting notably the subsequent annealing process.

关键词： Displacement cascades Molybdenum Defects Computer simulation

Experimental Study of Corner Stall in a Linear Compressor Cascade

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Chinese Journal of Aeronautics 2011年第3期24卷 235-242页

作者： MA Wei OTTAVY Xavier LU Lipeng LEBOEUF Francis GAO Feng Laboratoire de Mecanique des Fluides et d'Acoustique Ecole Centrale de Lyon Ecully 69134 France School of Jet Propulsion Beihang University Beijing 100191 China

In order to gain a better knowledge of the mechanisms and to calibrate computational fluid dynamics （CFD） tools including both Reynolds-averaged Navier-Stokes （RANS） and large eddy simulation （LES）, a detailed and accurate experimental study of comer stall in a linear compressor cascade has been carried out. Data are taken at a Reynolds number of 382 000 based on blade chord and inlet velocity. At first, inlet flow boundary layer is surveyed using hot-wire anemometry. Then in order to investigate the effects of incidence, measurements are acquired at five incidences, including static pressures on both blade and endwall sur- faces measured by pressure taps and the total pressure losses of outlet flow measured by a five-hole pressure probe. The maxi- mum losses as well as the extent of losses of the comer stall are presented as a function of the investigated incidences.

关键词： comer separation compressor cascades incidence hot-wire anemometry computational fluid dynamics

Cascading dam breach process simulation using a coupled modeling platform

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Science China(Technological Sciences) 2019年第8期62卷 1455-1466页

作者： LIU ZhiPing GUO XinLei ZHOU XingBo FU Hui XIA QingFu LI ShaoJun State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower Research Beijing 100038 China China Renewable Energy Engineering Institute Beijing 100120 China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan 430071 China

This study evaluates the possibility of a cascade failure by developing a coupled breach-modeling platform based on onedimensional flow modeling of the river channel, flood propagation, regulation process of reservoir fluctuation, overtopping with breaching, and wave damping downstream. A hyperbolic model of the DB-IWHR was embedded into the platform to simulate the dam breaching process. Five breach models and software were used to calculate the Tangjiashan barrier lake breaching. The results of a sensitivity study were then compared with the measured data. The peak flow and the time of occurrence were confirmed to be predictable with a reasonable accuracy if the input values were within ranges appropriate for the model. The approach was applied to a case involving two layout planning schemes for a cascade of rock-filled dams under extreme operating conditions. The probability of the failure of a key control cascade downstream caused by a continuous cascade breach upstream was simulated. Moreover, measures to prevent the transmission of risk by advance warnings were investigated. The proposed methodology and the discharge capacity measures provide guidelines to assess the risk to a cascade of dams under extreme operating conditions and offer support for the design criteria of unusual discharge structures for very large dams.

关键词： cascades dam breach extreme operating condition sensitivity analysis flood discharge structure