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cargo delivery without Presentation of the Bill of Lading in Chinese Maritime Law and Practice

Journal of Shipping and Ocean Engineering 2016年第4期6卷 191-205页

作者： Vehbi S. Ataergin Dean Professor of Law School at Near East University

This chapter examines the Chinese practice of delivery of the cargo without presentation of the bill of lading and the law and regulations governing that practice, and in the gaps left by laws and regulations, the approach established by the legal authorities and maritime courts. The necessities and causes for this risky action and possible suggestions will be considered, as will the approach of statute and judiciary. Potential and desirable reform will be discussed in light of the Rotterdam Rules. It is concluded that in order to facilitate cargo delivery, there would be a need to provide detailed legal guidance applicable to the many situations where the requisite documentation has failed to materialise.

关键词： Maritime law international trade law Chinese maritime law cargo delivery bill of lading.

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Genome engineering of the human gut microbiome

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Journal of Genetics and Genomics 2024年第5期51卷 479-491页

作者： Linggang Zheng Juntao Shen Ruiyue Chen Yucan Hu Wei Zhao Elaine Lai-Han Leung Lei Dai Dr Neher's Biophysics Laboratory for Innovative Drug Discovery/State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyTaipaMacao 999078China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Cancer Center Faculty of Health ScienceUniversity of MacaoMacao 999078China MOE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China

The human gut microbiome,a complex ecosystem,significantly influences host health,impacting crucial aspects such as metabolism and *** enhance our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health,the exploration of genome engineering for gut microbes is a promising ***,the complexities and diversities inherent in the gut microbiome pose substantial challenges to the development of effective genome engineering tools for human gut *** this comprehensive review,we provide an overview of the current progress and challenges in genome engineering of human gut commensal bacteria,whether executed in vitro or in situ.A specific focus is directed towards the advancements and prospects in cargo DNA delivery and high-throughput ***,we elucidate the immense potential of genome engineering methods to enhance our understanding of the human gut microbiome and engineer the microorganisms to enhance human health.

关键词： Non-model gut commensals Genomeediting reagents cargo delivery High-throughput genome engineering

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Polylysine complexes and their biomedical applications

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再生工程(英文) 2023年第1期4卷 20-27页

作者： Haofang Zhu Rui Liu Yixuan Shang Lingyun Sun Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

Poly-L-lysine(PLL)is a water-soluble biopolymer consist of repeating unit of *** displays intrinsic non-antigenicity,antibacterial property,biocompatibility,and biodegradability,and facile synthesis procedure,there-fore has attracted particular attention in various biomedical and pharmaceutical *** a brief introduction to PLL synthesis,this review focuses on the significant advances of PLL and PLL-derived complexes utilized in cargo delivery,tissue adhesives,and antibacterial ***,this review summarized the modification and optimization of PLL complexes for further clinical translational *** final section dis-cusses the challenges and opportunities of PLL-based complexes in the biomedical areas.

关键词： Polylysine cargo delivery bioadhesive antibacterial biomedicine

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Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

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Bioactive Materials 2022年第11期7卷 81-108页

作者： Sheng-Long Ding Xin Liu Xi-Yuan Zhao Ke-Tao Wang Wei Xiong Zi-Li Gao Cheng-Yi Sun Min-Xuan Jia Cheng Li Qi Gu Ming-Zhu Zhang Center of Foot and Ankle Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing100730China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Beijing Institute for Stem Cell and Regeneration University of Chinese Academy of SciencesBeijing100101China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijing100083China

Successful regeneration of cartilage tissue at a clinical scale has been a tremendous challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery, have been studied broadly across a wide range of medical fields, especially the cartilage tissue engineering (TE). Notably, microcarrier systems provide an attractive method for regulating cell phenotype and microtissue maturations, they also serve as powerful injectable carriers and are combined with new technologies for cartilage regeneration. In this review, we introduced the typical methods to fabricate various types of microcarriers and discussed the appropriate ma-terials for microcarriers. Furthermore, we highlighted recent progress of applications and general design prin-ciple for microcarriers. Finally, we summarized the current challenges and promising prospects of microcarrier-based systems for medical applications. Overall, this review provides comprehensive and systematic guidelines for the rational design and applications of microcarriers in cartilage TE.

关键词： Cartilage tissue engineering Cartilage regeneration Microcarriers cargo delivery Bioprinting

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