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Intrinsic Wave Velocity Propagation:A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on cardiac diastolic function in Breast Cancer Patients

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Current Medical Science 2023年第6期43卷 1229-1237页

作者： Xiao HUANG Xin-ying FAN Qiao CHENG Jun ZHANG Jie SUN Qiao-ying TANG You-bin DENG Xiao-jun BI Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Anthracycline chemotherapeutic agents have significant *** present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer patients by measuring the intrinsic wave velocity propagation(IVP),and evaluating the potential clinical value of IVP in detecting early LV diastolic function *** A total of 68 newly diagnosed breast cancer patients,who were treated with anthracycline-based chemotherapy,were *** echocardiography was performed at baseline(T0),and after 1,2,3,4 and 8 chemotherapeutic cycles(T1,T2,T3,T4 and T5,respectively).Then,the IVP,LV strain parameters[global longitudinal strain(GLS),longitudinal peak strain rate at systole(LSRs),longitudinal peak strain rate at early diastole(LSRe),longitudinal peak strain rate at late diastole(LSRa),and the E/LSRe ratio],and conventional echocardiographic parameters were obtained and further analyzed.A relative reduction of>15%in GLS was considered a marker of early LV subclinical *** Compared to the T0 stage,IVP significantly increased at the T1 ***,there were no significant changes in GLS,LSRs,or LSRe between the T0 and T1 *** parameters significantly decreased from the T2 *** started to significantly decrease at the T5 stage,and the E/LSRe ratio started to significantly increase at the T3 stage(all Pfunction after *** IVP is a potentially sensitive parameter for the early clinical assessment of anthracycline-related cardiac diastolic impairment.

关键词： breast cancer anthracycline chemotherapy drugs intrinsic wave velocity propagation myocardial stiffness cardiac diastolic function

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