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Determination of PDCD5 in Peripheral Blood Serum of cancer patients

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Chinese Journal of cancer Research 2011年第3期23卷 224-228页

作者： Yue Wang Guo-hong Wang Qing-yun Zhang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Clinical LaboratoryPeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：Programmed cell death 5 （PDCD5） is an apoptosis related gene and plays an important role in the pathogenesis and development of *** PDCD5 is present in peripheral blood serum has not been *** aim of this study is to determine the contents of PDCD5 protein in peripheral blood serum of cancer patients,as well as normal ***：ELISA was used to detect the serum PDCD5 concentrations in 100 normal persons,83 patients with breast cancer,74 patients with gastrointestinal tract cancer and 41 patients with lung *** results were statistically analyzed and ***：PDCD5 could be detected in peripheral blood serum in both normal subjects and cancer *** serum PDCD5 contents in normal persons ranged from 3.8 to 6.1 ng/ml with a median of 4.70±0.68 ng/*** cancer patients the PDCD5 levels were 4.59±0.90,4.79±1.14 and 10.43±22.34 ng/ml for breast cancer,gastrointestinal cancer and lung cancer patients *** was no statistically significant difference between the serum PDCD5 concentrations of normal persons and cancer ***：PDCD5 is present in peripheral *** PDCD5 levels in cancer patients are not statistically different from that of normal persons,though decreased expression of PDCD5 in malignant tissues has been found.

关键词： PDCD5 Apoptosis cancer patients ELISA

Attitudes towards pain management in hospitalized cancer patients and their influencing factors

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Chinese Journal of cancer Research 2017年第1期29卷 75-85页

作者： Fangli Lou Shaomei Shang Department of Fundamental Nursing Peking University School of Nursing Beijing 100191 China

Objective： To investigate patients＇ attitudes towards cancer pain management and analyze the factors influencing these ***： The self-developed Demographic and Disease-Related Information Questionnaires, Pain Management Barriers Questionnaire-Taiwan form（BQT）, and Pain Knowledge Questionnaire were administered to 363 pairs of hospitalized cancer patients and their caregivers from the oncology departments of 7 hospitals in Beijing, ***： The average patient score for attitudes towards pain management was 2.96±0.49. The dimension scores indicated good attitudes in three areas（scores 〈2.5）, ＂Desire to be good＂（2.22±1.04）, ＂Fatalism＂（2.08±0.81） and＂Religious fatalism＂（1.86±1.00）, and poor attitudes in six areas（scores ≥2.5）, ＂Tolerance＂（3.83±0.96）, ＂Use of analgesics as needed（p.r.n.）＂（3.73±1.01）, ＂Addiction＂（3.44±1.05）, ＂Disease progression＂（3.28±1.26）, ＂Distraction of physicians＂（3.16±1.07） and ＂Side effects＂（2.99±0.68）. Two factors were entered into the regression equation：the caregivers＇ attitudes towards cancer pain management and the patients＇ pain knowledge. These two factors explained 23.2% of the total variance in the patients＇ average scores for their attitudes towards cancer pain ***： The patients＇ attitudes towards cancer pain management were poor and could be influenced by the caregivers＇ attitudes and the patients＇ pain knowledge, and thus need to be improved.

关键词： cancer patients cancer pain attitudes towards cancer pain management

Implantable port thrombosis in cancer patients: a monocentric experience

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cancer Biology & Medicine 2016年第3期13卷 384-388页

作者： Manel Dridi Nesrine Mejri Soumaya Labidi Mehdi Afrit Houda El Benna Khaoula Ben Miled Hamouda Boussen Medical Oncology Department Abderrahmen Mami Hospital Radiology Department Abderrahmen Mami Hospital

Objective: Implantable port thrombosis(IPT) in cancer patients is a relatively rare but severe complication. Several factors are reportedly associated with the occurrence of thrombosis. We aimed to describe the prevalence and the anatomoclinical features of IPT observed in cancer patients who were treated in a medical oncology department in ***: A total of 600 cancer patients who had port implantation from January 2013 to December 2015 were retrospectively identified. Cases with symptomatic/incidental IPT(radiologically confirmed) were further identified. Epidemiological and anatomoclinical features were collected from patient records and the department ***: We observed that 33 of the 600 patients had IPT; thus, the prevalence was 5.5%. The median age was 57 years, and the gender ratio was 0.43. Overweight or obesity was observed in 73% of the patients. IPT occurred mainly in patients with breast(36.4%) and colorectal(33.3%) cancers, which were mostly nonmetastatic(79%). At least one identified classical thromboembolic risk factor was found in 13 patients(smoking in 9, tamoxifen in 2). IPT was symptomatic in 93% of the cases, occurring within an average time of 56 days. Implantable ports were removed because of infection in 2 cases and nonfunctionality in 3 cases. IPT treatment was based on low-molecular-weight heparins(94%) and antivitamin K(6%) for an average of 130 days. Four patients had post-therapy complications: one thrombosis recurrence and three ***: IPT cases in the 600 patients were observed to occur in obese nonmetastatic cancer patients within the first 3 months after IP implantation.

关键词： Implantable port cancer patients thrombosis

Validation And Reliability of Distress Thermometer in Chinese cancer patients

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Chinese Journal of cancer Research 2011年第1期23卷 54-58页

作者： Li-li Tang Ye-ning Zhang Ying Pang Hai-wei Zhang Li-li Song Key laboratory of Corcinogenesis and Translational Research (Ministry of Education) Department of Psycho-OntologyPeking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To examine the validation and reliability of the distress thermometer（DT） recommended by National Comprehensive cancer Network（NCCN） in Chinese cancer ***：A total of 574 Chinese cancer patients from Beijing cancer Hospital completed the detection of DT,the Hospital Anxiety and Depression Scale（HADS） and Symptom Checklist 90（SCL-90）,Receiver Operating Characteristic（ROC） curve and Area Under the Curve（AUC） were used to analyze the validation relative to HADS and *** patients with DT≥4 and whose distress caused by emotional problems were interviewed with the MiNi International Neuro-psychiatric Interview（MINI）（Chinese Version 5.0）.This version was used to analyze cancer patients＇ psychological and Psychiatric symptoms during the cancer process;*** 106 cancer patients in rehabilitation stage and stable condition were asked to fill in DT two times,at the base time and after 7-10 ***：Data of ROC indicates that a DT cutoff score of 4 yielded AUC of 0.80 with a optimal sensitivity（0.80） and specificity（0.70） relative to HADS,and AUC of 0.83 with the greatest sensitivity（0.87） and specificity（0.72） against *** DT also has acceptable test-retest reliability（r=0.800,P=0.000）;According to the interview results,the most common psychiatric problems cancer patients have adjustment disorder,depression,and ***：The data suggest that DT has acceptable overall accuracy and reliability as a screening tool for testing distress severity and specific problems causing distress in Chinese cancer *** is worth being used in oncology clinic,the rapid screening and interview could help caregivers to identify psychological and psychiatric problems of cancer patients and provide useful information for further treatment.

关键词： Validation Reliability cancer patients Distress thermometer

Perspectives and Challenges of Family Members in Providing Mental Support to cancer patients:A Qualitative Study in Beijing,China

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Psycho-Oncologie 2024年第4期18卷 257-269页

作者： Wei Wang Lan Li Department of Social Sciences Universiti SelangorBatang Berjuntai45600Selangor Beijing Youth Research Association Beijing100044China Sinounited Investment Group Corporation Limited Postdoctoral Programme Beijing102611China

This study explores the perspectives and challenges faced by family members providing mental support to cancer patients in Beijing,*** primary objective is to understand the emotional and practical roles family members undertake and the difficulties they *** a qualitative research design,data were collected through semi-structured interviews with family caregivers of cancer *** analysis revealed several key themes:the dual burden of emotional support and caregiving responsibilities,the impact on daily life and personal well-being,the role and effectiveness of external support systems,perceptions of medical staff support,and the common challenges and conflicts faced in *** findings highlight the critical need for comprehensive support systems that address both the emotional and practical needs of family *** for enhancing family-centered support programs in oncology settings are discussed.

关键词： Family caregivers mental health support cancer patients qualitative study Beijing caregiving challenges emotional support healthcare systems

The Impact of Social Support on the Mental Health of cancer patients:Evidence from China

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Psycho-Oncologie 2024年第1期18卷 69-77页

作者： Wanxiu Zhu School of Public Administration and Law Hunan Agricultural UniversityChangsha410128China

Exploring the relationship between social support and the mental health of cancer patients is a vital endeavor for enhancing mental *** objective of this study was to explore the relationship between social support and psychological well-being in cancer patients and to provide new empirical evidence for psychological improvement in cancer *** research holds significant practical implications for optimizing China’s public health system and strengthening the development of a healthy *** data from the 2018 China Health and Retirement Longitudinal Study(CHARLS)database,we empirically examined the influence of social support on the mental health of cancer *** such as Ordered Probit and OLogit were used to provide empirical evidence and theoretical insights for enhancing the mental health of cancer patients in a context marked by a high prevalence of *** findings indicated that both formal and informal social support mechanisms were effective in improving the mental health of cancer ***,we utilized the propensity score matching(PSM)model to eliminate the endogeneity issue associated with sample selectivity *** results obtained through PSM demonstrated robustness,underscoring the importance of addressing sample selectivity bias when assessing the impact of social support on the mental health of cancer ***,the Chinese government is recommended to prioritize the use of social support as a means to proactively enhance the mental health of cancer patients,thereby continuously elevating their overall quality of life.

关键词： cancer patients social support mental health

Progress in Research on the Impact of Religious Psychological Coping on the Holistic Well-Being of cancer patients and Relevant Factors

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Psycho-Oncologie 2024年第4期18卷 249-255页

作者： Jing Li Minghui Li Guanghuan Xie Faculty of Education University of MacaoMacao999078China College of Education for the Future Beijing Normal UniversityBeijing100020China School of Ethnic Studies Xizang Minzu UniversityLhasa859000China

This study reviews the historical development,current applications,and multifaceted impacts of religious psychological coping on the physical and mental health of cancer *** a method for coping with life’s pressures through religious beliefs or activities,religious psychological coping has been proven to alleviate the negative emotions of cancer patients and enhance their spiritual well-being and quality of life(QOL).Research indicates that religious faith can alleviate the physical symptoms of cancer patients,extend survival time,reduce the fear of death,assist in coping with treatment side effects,and improve self-efficacy and overall quality of ***,this study explores factors influencing religious psychological coping,including demographic and sociological characteristics,the faith status of caregivers,types of religion,the relationship between the course of the disease and the duration of belief,and psychological *** the cultural differences between China and other countries,this study calls for further research into the real experiences of cancer patients with religious beliefs and provides theoretical guidance for clinical nursing practices to achieve holistic care for the body,mind,and spirit of cancer patients.

关键词： Religious psychological coping cancer patients holistic health quality of life religious belief

Cognitive behavioral therapy on personality characteristics of cancer patients

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World Journal of Clinical Cases 2021年第31期9卷 9386-9394页

作者： Xiao-Hui Yuan Juan Peng Shu-Wei Hu Yong Yang Yu-Ju Bai Zunyi Medical University Zunyi 563000Guizhou ProvinceChina Teaching and Research Office of Medical Psychology Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Oncology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so *** often feel anger,anxiety,depression,and other negative psychological reactions in the process of *** To explore the effects of cognitive behavioral therapy on the personality characteristics of cancer *** According to the matching design requirements,150 cancer patients were divided into 3 groups based on sex,age,condition,and cultural *** in the control group received conventional *** in experimental group 1 received an intervention based on conventional treatment combined with cognitive behavioral *** in experimental group 2 received family members'participation in addition to the treatment given in experimental group *** Eysenck personality questionnaire was used to investigate all the patients before and after the intervention,and the scores for psychosis,introversion,neuroticism,and concealment degree were *** Compared with the control group,for experimental group 1 and experimental group 2 before and after the intervention,the four dimensions of mental quality,neuroticism,introversion and concealment degree all decreased,and the difference was statistically significant(P0.05)among the control group,experimental group 1,and experimental group 2 for two personality traits,psychoticism and neuroticism,both inside and outside degree and all four *** Simple cognitive behavioral therapy could not change the personality characteristics of cancer patients quickly,but the patients’personality characteristics were significantly improved after treatment.

关键词： Cognitive behavioral therapy cancer patients Personality characteristics Psychosis Introversion Neuroticism Degree of validity

Depression and anxiety among cancer patients visiting a tertiary care cancer hospital

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World Journal of Psychiatry 2024年第2期14卷 287-295页

作者： Maheshor Kaphle Diya Bajracharya Nirmala Regmi Dipsikha Aryal Rajesh Karki Department of Public Health Peoples Dental College and HospitalTribhuvan UniversityKathmandu 44600BagmatiNepal Department of Public Health CiST CollegePokhara UniversityKathmandu 44600BagmatiNepal Department of Oncology Kanti HospitalMaharajgunjKathmandu 44600Nepal Central Department of Public Health Institute of MedicineTribhuvan UniversityMaharajgunjKathmandu 44600BagmatiNepal

BACKGROUND cancer patients frequently experience psychological problems related to reactions to cancer diagnosis,cancer type and stage,treatment effects,recurrence,fear of end-of-life,survivorship,and financial *** and anxiety are both psychological and physiological disturbances among cancer *** To assess the prevalence of depression and anxiety among cancer patients attending a tertiary care cancer *** A cross-sectional study was conducted at Bhaktapur cancer Hospital in Kathmandu Valley among 220 cancer patients aged from 18 years to 70 *** approval was taken from the Institutional Review Committee of CiST *** sampling was used to interview patients with the standardized Patient-Health Questionnaire(PHQ-9)for Depression and Hospital Anxiety and Depression sub-scale(HADS-A)for ***-Data was used for data entry and transferred to SPSS Version 25 for *** The study revealed that of 220 patients,most of the respondents belonged to the age group 51-60 *** than half 131(59.6%)of the respondents were female,most of them had depression,and one-third had *** the respondents,124(56.4%)had mild depression,70(31.8%)had moderate depression,and 3(1.3%)had severe depression;79(35.9%)had mild anxiety,64(29.1%)had moderate anxiety,and 4(1.8%)had severe *** Most respondents were depressed and one-third had *** than half and nearly one-third had mild and moderate depression,respectively,and nearly one-third had mild and moderate anxiety,which is higher than other studies.

关键词： Anxiety cancer patients Depression Nepal Prevalence