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Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care cancer diagnostics

Nano-Micro Letters 2022年第6期14卷 248-281页

作者： Arpana Parihar Ayushi Singhal Neeraj Kumar Raju Khan MohdAkram Khan Avanish KSrivastava Industrial Waste Utilization Nano and BiomaterialsCSIR-Advanced Materials and Processes Research Institute(AMPRI)Hoshangabad RoadBhopal 462026MPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of ***,2 D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of *** high surface area,surface functional groups availability,and excellent electrical conductivity of MXene make it the 2 D material of choice for the fabrication of advanced electrochemical biosensors for disease ***-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of ***,the stability,ease of synthesis,good reproducibility,and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic *** this review,the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been ***,various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been ***,futuristic sensing applications along with challenges will be deliberated herein.

关键词： MXene Electrochemical devices POCT Aptamer cancer diagnostics

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Cluster size distribution of cancer cells in blood using stopped-flow centrifugation along scale-matched gaps of a radially inclined rail

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Microsystems & Nanoengineering 2015年第1期1卷 97-105页

作者： Macdara Glynn Charles Nwankire Kate Lemass David J.Kinahan Jens Ducrée Biomedical diagnostics Institute National Centre for Sensor ResearchSchool of Physical SciencesDublin City UniversityIreland

There is increasing evidence that,in addition to their presence,the propensity of circulating tumour cells to form multi-cellular clusters bears significant information about both cellular resistance to chemotherapy and overall *** present a novel two-stage,stopped-flow,continuous centrifugal sedimentation strategy to measure the size distributions of events(defined here as cells or clusters thereof)in a blood *** off-chip removal of red blood cells,healthy white blood cells are sequestered by *** purified events are then resolved along a radially inclined rail featuring a series of gaps with increasing width,each connected to a designated outer collection *** isolation of candidate events independent of targetspecific epitopes is successfully demonstrated for HL60(EpCAM positive)and sk-mel28(EpCAM negative)cells using identical protocols and *** propensity to form clusters was quantified for a number of cell lines,showing a negligible,moderate or elevated tendency towards cluster *** show that the occupancy distribution of the collection bins closely correlates with the range of cluster sizes intrinsic to the specific cell line.

关键词： centrifugal microfluidics lab-on-a-disc cancer diagnostics cellular clustering

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