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Recent Progress in Nanoscale Covalent Organic Frameworks for cancer diagnosis and therapy

Nano-Micro Letters 2021年第11期13卷 246-265页

作者： Shuncheng Yao Zhirong Liu Linlin Li Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

Covalent organic frameworks(COFs)as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic *** precise assembly,welldefined coordination network,and tunable porosity endow COFs with diverse characteristics such as low density,high crystallinity,porous structure,and large specific-surface area,as well as versatile functions and active sites that can be tuned at molecular and atomic *** unique properties make them excellent candidate materials for biomedical applications,such as drug delivery,diagnostic imaging,and disease *** realize these functions,the components,dimensions,and guest molecule loading into COFs have a great influence on their performance in various *** this review,we first introduce the influence of dimensions,building blocks,and synthetic conditions on the chemical stability,pore structure,and chemical interaction with guest molecules of ***,the applications of COFs in cancer diagnosis and therapy are ***,some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed.

关键词： Covalent organic frameworks Nanomedicine Drug delivery cancer diagnosis and therapy

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Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy

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National Science Review 2015年第1期2卷 71-84页

作者： Hong-Min Meng Ting Fu Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyCollaborative Innovation Center for Molecular Engineering for TheranosticsHunan University

Nucleic acid aptamers, which are generated by a novel technique called SELEX(systematic evolution of ligands by exponential enrichment), have recently atracted signiicant atention in the ield of early detection and treatment of cancer based on their numerous merits, such as high ainity, high speciicity,small size, litle immunogenicity, stable structures, and ease of chemical modiication. Furthermore,aptamers can gain more lexibility as cancer cell targeting tools when conjugated to nanomaterials,including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric *** discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with diferent nanomaterials.

关键词： aptamer cell-SELEX nanomaterial cancer cells cancer diagnosis and therapy

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Self-assembling bile pigments for cancer diagnosis and therapy

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Aggregate 2021年第1期2卷 84-94页

作者： Kaiwei Chen Ruirui Xing Xuehai Yan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingChina School of Chemical Engineering University of Chinese Academy of SciencesBeijingChina Center for Mesoscience Institute of Process EngineeringChinese Academy of SciencesBeijingChina

Nanomaterials that integrate multiple functions provide promising opportunities for noninvasive and targeted cancer diagnosis and ***,the unclear metabolic pathway to nanomaterials brought difficulties to clinical *** bile pigments are endogenous functional materials with excellent biocompatibility and low *** materials based on endogenous bile pigments provide a decent solution to this *** this review,the features and functions of self-assembling bile pigments are discussed in detail for cancer diagnosis and treatment *** are put on the intrinsic physicochemical characteristics of bile pigments and their applications,including drug delivery,photoacoustic imaging,photothermal therapy,and anti-inflammation *** review will promote the exploration of these areas and tremendously realize the innovative applications of self-assembling biliverdin/bilirubin nanomaterials toward cancer diagnosis and therapy.

关键词： self-assembly endogenous bile pigments nanomaterials cancer diagnosis and therapy

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Translational research case studies:Development of antibodies for cancer diagnosis and therapy

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Journal of Nanjing Medical University 2007年第6期21卷 385-385页

作者： Brian Cao Antibody Technology Laboratory Van Andel Research InstituteUSA 49506

Antibodies are primary tools in several areas of biomedical sciences, including basic research, diagnostics, and molecular therapeutics. Antibodies are widely used in diagnostic applications for clinical medicine. Analysis of cells and tissues in pathology laboratories includes the use of antibodies on tissue sections. Further, antibodies are making rapid inroads into medical therapeutics, driven by technological evolution from chimeric and humanized to fully human antibodies. The therapeutic antibody market has the potential to reach $30 billion by 2010. Our lab has developed a monoclonal antibody, named Met4 that was raised against the extracellular domain of Met specifically with the goal of measuring Met in FFPE tissues. The Met receptor kinase is expressed on the cell surface of a significant number and variety of human primary solid tumors and in their metastases. The characterization of the Met4 antibody suggests it should possess adequate performance for quantification of Met expression in clinical specimens. We have also generated a fully human Fab fragment against EGFR; conjugated it to taxol as an immuno-chemotherapy agent; and investigated its in vitro antitumor efficacy on EGFR positive A431 epidermoid carcinoma cells.

关键词： monoclonal antibody cancer diagnosis and therapy Met 4

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Multifunctional Two-photon Sensitized Gd2O3: Eu3+ Hollow Nanoparticles for Glioblastoma diagnosis and therapy

Multifunctional Two-photon Sensitized Gd2O3: Eu3+ Hollow Nan...

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中国化学会第九届全国无机化学学术会议

作者： Tingting Shen Yu Zhang Yu Tang Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

cancer diagnosis and therapy in vivo generally requires a well-designed nanoscale platform to integrate multiple functionalities for desired antitumor efficiency. In this study, the multifunctional two-photon（TP） sensitized Gd2O3:Eu3+@P（NIPAm-co-MAA）@THA@c RGD（TPNPs@c RGD） hollow nanoparticles has been prepared for glioblastoma diagnosis and therapy（Fig. 1）. As expected, the designed TPNPs@c RGD nanoparticles display a versatile platform for glioblastoma cancer theranostics including simultaneous targeting with c RGD, dual-mode imaging with two-photon luminescence（TPL）/magnetic resonance imaging（MRI）, stimuli-responsive controlled drug delivery with coating polymer P（NIPAm-co-MAA）, and real-time dual-mode monitoring of the doses of drug release with TPL and MRI signals. The introduction of ligand THA not only confers the nanoparticles TPL properties, but also decreases the biotoxicity of rare-earth ions. Meanwhile, it was found that the incorporation of Gd3+ generates obvious MRI signals, and moreover, importantly enhances the red emission of Eu3+ indirectly by increasing the absorption of the ligand THA.1 And the bright TPL can be observed at the excitation wavelength of 808 nm, which skillfully avoids severe burns attributing to the absorption of water molecules in NIR region.2 A more interesting thing is that, the loading of drug DOX can changed the coordination environments around the active Eu3+ ions, which results in the improvement of photoluminescence stability against the acid and high temperature environment. When the mesopores open, DOX began to leak out, the hollow cavity gradually leaves more room to favors the diffusion and access of water molecules and H+ from outside, consequently, the TPL emission intensity dropped and water molecules relaxation effect enhanced gradually,3 so the as-prepared hybrid nanoparticles can exhibit outstanding monitoring effect by using the simultaneous changes of TPL and MRI signals to track the extent of drug release.

关键词： hollow nanoparticles energy transfer thermo/pH-coupling stimulus drug release dual-mode imaging and monitoring cancer diagnosis and therapy

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