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Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study

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cancer Biology & Medicine 2024年第8期21卷 692-702页

作者： Md Mijanur Rahman Michael David David Goldsbury Karen Canfell Kou Kou Paramita Dasgupta Peter Baade Xue Qin Yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydneyNSW 1340Australia School of Medicine and Dentistry Griffith UniversityGold CoastQLD 4222Australia cancer Council Queensland BrisbaneQLD 4006Australia

Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common ***: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average ***: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expec

关键词： cancer diagnosis life expectancy loss of life expectancy area-level socioeconomic status flexible parametric model

Artificial intelligence for assisting cancer diagnosis and treatment in the era of precision medicine

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cancer Communications 2021年第11期41卷 1100-1115页

作者： Zi-Hang Chen Li Lin Chen-Fei Wu Chao-Feng Li Rui-Hua Xu Ying Sun Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Artificial Intelligence Laboratory State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Over the past decade,artificial intelligence(AI)has contributed substantially to the resolution of various medical problems,including *** learning(DL),a subfield of AI,is characterized by its ability to perform automated feature extraction and has great power in the assimilation and evaluation of large amounts of complicated *** the basis of a large quantity of medical data and novel computational technologies,AI,especially DL,has been applied in various aspects of oncology research and has the potential to enhance cancer diagnosis and *** applications range from early cancer detection,diagnosis,classification and grading,molecular characterization of tumors,prediction of patient outcomes and treatment responses,personalized treatment,automatic radiotherapy workflows,novel anti-cancer drug discovery,and clinical *** this review,we introduced the general principle of AI,summarized major areas of its application for cancer diagnosis and treatment,and discussed its future directions and remaining *** the adoption of AI in clinical use is increasing,we anticipate the arrival of AI-powered cancer care.

关键词： artificial intelligence cancer diagnosis cancer research cancer treatment convolutional neural network deep learning deep neural network oncology

cancer diagnosis System Based on the Spectra of Serum

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Semiconductor Photonics and Technology 1999年第1期5卷 29-34页

作者： QIBing ZHANGZhilin 等 TsinghuaUniversity Beijing100084CHN DalianUniversityofTechnology Dalian116023CHN

Autofluorescence spectra from the serum of health man and cancer patients have been measured and analyzed. Two obviously spectra characteristics of the serum have been discussed in detail. A novel laser cancer diagnos... 详细信息

关键词： cancer diagnosis Fluorescence Spectra Serum

Rational design of lysosomal targeting carbon dots by retrosynthesis for in vivo cancer diagnosis

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Rational design of lysosomal targeting carbon dots by retros...

cancer associated alteration of Human Serum IgG galactosylation and its potential as a pan-cancer diagnosis biomarker

河南省化学会2020年学术年会

作者：耿欣孙远强李朝辉屈凌波郑州大学化学学院

Taking lysosome as the marker is effective for accurately distinguishing cancer cells from normal cells toward cancer diagnosis,but it is challenging to monitor in visualization due to the lack of photostable probes with strong fluorescence in acidic *** dots (CDs) with their high stability and strong biocompatibility show enormous potential in ***,a class of piperazine modified lysosomal targeting CDs (LysoCDs) was developed in one step via retrosynthesis *** on the fact of lysosomes in cancer cells with larger numbers and volume,lower pH and the consequent better lipophilic amines-accumulation degree than that in normal cells,LysoCDs with the high fluorescence intensity and quantum yield (QY) in acidic environment can be selectively accumulated in and light up lysosomes of cancer ***,distinguishing tumors from organs in vivo bioimaging is demonstrated,thus promising the great potential in cancer diagnosis.

关键词： Carbon dots lysosomes cancer diagnosis

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Cancer associated alteration of Human Serum IgG galactosylat...

Multi-functional Dendrimers:New Platforms for cancer Targeting Therapy and cancer diagnosis

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Shifang Ren Zejian Zhang Wenjun Qin Ruihuan Qin Jin Han Jianxin Gu Key Laboratory of Glycoconjugate Research Ministry of Public Health Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan University

Analysis of blood-based glycans represents a new strategy for cancer *** G(IgG),a highly abundant glycoprotein in serum,is known to mediate a variety of blood immune *** has been an increasing interest in the analysis of the N-glycan profile of human IgG in healthy and disease states,such as auto-immune diseases and *** altered glycosylation of total serum IgG has been profiled individually in ovarian,prostate,gastric cancers,no studies have systematically investigated the alteration of IgG glycosylation in multiple cancers *** addition,the sample sizes in previous studies were *** high throughput analytical method based on mass spectrometry for relative quantitative analysis of IgG glycans we previously developed,we designed for the first time a large-scale(n=5600),multi-institute study to assess the quantitative changes of IgG glycosylation in 12 types of cancers,inflammatory diseases,benign conditions as well as healthy individuals *** demonstrated that the distribution patterns of serum IgG galactosylation have similar alterations in multiple types of *** thus we provided evidences for the first time that serum IgG galactosylation has great potential to be used as a non-invasive pan-cancer biomarker for early-stage cancer detection and cancer *** studies are underway to investigate the role and mechanism of IgG galactosylation in readout of immunological status.

关键词： IgG galactosylation cancer diagnosis pan-cancer biomarker

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Multi-functional Dendrimers:New Platforms for Cancer Targeti...

Oral Microbiota:A New Insight into cancer Progression,diagnosis and Treatment

华东六省一市生物化学与分子生物学学会2006年学术交流会

作者： Cheng Yiyun (Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Science, University of Science and Technology of ChinaHefei, Anhui 230026, People’s Republic of China)

An anti-cancer drug must be able to find out a cancer cell from a large number of normal cells found in the body then provide its toxic agent to kill the cancer cell. However, single small molecules function poorly at these tasks, thereby requiring the use of targeting therapy in clinical practices. In this present study, we offer a list of functional dendrimers with a high drug payload and targeting agents to solve this challenging problem. Dendrimers are perfectly designed macromolecules with well-defined size and molecular weight or shape. They have a large number of functional terminal groups on the outer shell comparing with conventional macromolecule which responsible for high solubility or reactivity. Also, dendrimers possess empty internal hydrophobic cavities, which make them suitable for cancer drug delivery systems. Up to now, we have already investigated the potential use of dendrimers as carriers of hydrophobic drugs including Non-Steroidal Anti-Inflammatory Drugs, Anti-bacterial agents, Anti-leukemic drugs, Anti-cancer drugs, Antiepileptic drugs. Different types of functional dendrimers conjugate with targeting agents, imaging agents or toxic agents were synthesized and characterized. We are now on the process of evaluating different targeting agents on their targeting efficiency. Among which, folic acid receptor-mediated tumor targeting have already shown excellent targeting ability. Furthermore, biotin-avidin mediated liver targeting;vitamin and sugar derivates-mediated many tumors targeting;lectin-mediated epithelia, lymphatic or liver targeting;antibody mediated tumor specific surface antigen targeting and some peptides, insulin or HSA linked dendrimers for liver targeting are also under investigation. The results we obtained showed that dendrimers could offer the possibilities in the biomedical application field. They are suitable nano-platforms for cancer targeting for both therapy and diagnosis.

关键词： Dendrimers cancer targeting cancer diagnosis targeting efficiency

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Phenomics 2023年第5期3卷 535-547页

作者： Xiu-Li Wang Hua-Wen Xu Ning-Ning Liu State Key Laboratory of Systems Medicine for cancer Center for Single-Cell OmicsSchool of Public HealthSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China

The polymorphic microbiome has been defined as one of the“Hallmarks of cancer”.Extensive studies have now uncovered the role of oral microbiota in cancer development and ***,fungi,archaea,and viruses in the oral cavity interact dynamically with the oral microenvironment to maintain the oral micro-ecological *** complex interaction is influenced by many factors,such as maternal transmission,personal factors and environmental *** of oral microbiota can disturbed this host-microbiota interaction,leading to systemic *** studies have shown the potential associations between oral microbiota and a variety of ***,the underlying mechanisms and therapeutic insights are still poorly *** this review,we mainly focus on the following aspects:(1)the factors affect oral microbiota composition and function;(2)the interaction between microenvironment and oral microbiota;(3)the role of multi-kingdom oral microbiota in human health;(4)the potential underlying mechanisms and therapeutic benefits of oral microbiota against ***,we aim to describe the impact of oral microbiota on cancer progression and provide novel therapeutic insights into cancer prevention and treatment by targeting oral microbiota.

关键词： Oral microbiota cancer cancer diagnosis Tumor therapy

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

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Frontiers of Medicine 2022年第2期16卷 157-175页

作者： Ying Deng Zhaowei Sun Lei Wang Minghui Wang Jie Yang Genxi Li State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China

cancer imposes a severe threat to people’s health and lives,thus pressing a huge medical and economic burden on individuals and ***,early diagnosis of cancer is indispensable in the timely prevention and effective treatment for *** has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions,which reflects remarkable information regarding the cancer microenvironment,and plays an important role in the occurrence and evolution of ***,biosensors have gained great attention for the detection of exosomes due to their superior properties,such as convenient operation,real-time readout,high sensitivity,and remarkable specificity,suggesting promising biomedical applications in the early diagnosis of *** this review,the latest advances of biosensors regarding the assay of exosomes were summarized,and the superiorities of exosomes as markers for the early diagnosis of cancer were ***,the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.

关键词： biosensor exosome cancer diagnosis

Multifunctional lymph-targeted platform based Mn@mSiO2 nanocomposites： Combining PFOB dual-mode imaging and DOX for cancer diagnose treatment on for and

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Nano Research 2016年第2期9卷 473-489页

作者： Tian Liu Guangyu Wu Jiejun Cheng Qing Lu Yanjie Yao Zhenjing Liu Dongchen Zhu Juan Zhou Jianrong Xu Jun Zhu Dannong He Country School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China National Engineering Research Center for Nanotechnology 28 East Jiang Chuan Road Shanghai 200241 China Department of Radiology Shanghai Renji Hospital Shanghai.liao Tong University School of Medicine 1630 Dong Fang Rd Shanghai 200127 China

A universal platform with M_n doping and hyaluronic acid （HA） modification, based on mesoporous silica （mSiO2）, was designed and used as a basic multifunctional material with magnetic resonance （MR） imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide （PFOB） and hydrophilic doxorubicin （DOX）, were loaded into the channels to obtain PFOB@Mn@mSiO2@HA （PMMH） or DOX@Mn@mSiO2@HA （DMMH） or imaging and therapy, respectively. The were highly targeted to the lymph system in nanoparticles for dual-mode imaging PMMH and DMMH nanoparticles vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparficles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.

关键词： mulfifuncfional platform dual-mode imaging magnetic resonance imaging (MRI) ultrasound imaging cancer diagnosis