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Berberine induced autophagic cell death by elevating GRP78 level in cancer cells

Berberine induced autophagic cell death by elevating GRP78 l...

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中国生物化学与分子生物学会2016年全国学术会议

作者： Xiaoqin La Zhuoyu Li Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Biotechnology Shanxi University

Berberine,an isoquinoline alkaloid extracted from Coptidis Rhizoma(Huanglian in Chinese),has been shown to induce cancer cell autophagic death that defined as Type II Programmed cell death(PCD)in vitro.Glucose regulated protein 78(GRP78)is associated with the stress-induced autophagy.However,the related mechanisms between berberine-induced

关键词： berberine autophagy cancer cell death GRP78 VPS34

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Berberine induced autophagic cell death by elevating GRP78 level in cancer cells

Berberine induced autophagic cell death by elevating GRP78 l...

引用

2017第七届泛环渤海生物化学与分子生物学会学术交流会

作者： Xiaoqin La Zhuoyu Li Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of Nationa1 Ministry of EducationShanxi University Institutes of Biomedical Sciences Shanxi University School of Life Science Shanxi University

Autophagy is the cellular process that delivers damaged organelles and invasive bacteria to lysosomes for degradation so as to maintain the intracellular homeostasis during various cell stresses.These substrates are engulfed along with bulk cytoplasm by double-membrane,with the extension and fusion of membrane edge,which results in the formation of the autophagosome.After the fusion of autophagosome and lysosome,the degradation products are recycled back into cytosol and reused to enhance cell survival during nutrient deprivation.One potential regulator of autophagy is the activation of the unfolded protein response(UPR),an endoplasmic reticulum stress pathway.GRP78,a key upstream activator of the UPR,participates in promoting protein folding.assembly and degradation,endoplasmic reticulum stress sensing,and cellular calcium homeostasis.High level of GRP78 contributes to the stress-induced autophagy and functional blockade of the proteasome induces GRP78 to promote autophagosome formation.As a major active compound of Coptidis Rhizoma(Huanglian in Chinese),berberine is an isoquinoline alkaloid,which has long been used as a nonprescription oral drug in China for the treatment of gut infections and diarrhea.Importantly,the antineoplastic activities of berberine were intensive studied and reported since 1990s.A great portion of studies made effort on revealing of cytotoxicity,metastasis inhibition and antiangiogenic of berberine.Other studies focus on cell-cycle checkpoint control,DNA repair and regulation of initiating oxidative stress in cancer cells,which bring some new mechanisms underlying the antitumor of berberine to light.Recent studies have revealed the berberine can trigger autophagic cell death of tumor,and its beneficial effects are receded when the autophagy process is genetically or pharmacologically inactivated,which suggests that autophagy is indispensable for the protective effects of berberine.Here,we reported that berberine could induce autophagic cancer cell death by the elevation of GRP78.The res

关键词： berberine autophagy cancer cell death GRP78 VPS34

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