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Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 270-278页

作者： Marzieh Rashedinia Azita Nasrollahi Marzieh Shafaghat Shahrzad Momeni Forough Iranpak Jamileh Saberzadeh Rita Arabsolghar Zahra Sabahi Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology and Toxicology Faculty of PharmacyShiraz University of Medical SciencesShirazIran Diagnostic Laboratory Sciences and Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShirazIran Department of Biochemistry Islamic Azad University of ShirazShirazIran Department of Medical Laboratory Sciences School of Paramedical SciencesShiraz University of Medical SciencesShirazIran

Objective:To investigate the effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)***:The antiproliferative effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions were examined by MTT ***,colony-forming,reactive oxidative species(ROS)generation,apoptosis induction,autophagy,mitochondrial membrane potential,and mitochondrial mass were ***:At 24 and 72 h,no significant differences were observed in the viability of HepG2 cells between the control and syringic acid+Fe(Ⅱ)***,exposure of HepG2 cells to syringic acid+Cu(Ⅱ)for 72 h reduced the cell viability ***,ROS formation,induction of apoptosis,and autophagic vacuoles were significantly increased in HepG2 cells without marked changes in mitochondrial membrane potential and mitochondrial ***,syringic acid+Cu(Ⅱ)reduced the plating efficiency and surviving fraction ***:The combination of syringic acid with Cu(Ⅱ)was toxic to cancer cells and showed pro-oxidant *** addition,this combination induced autophagy in cancer cells with less cytotoxic effects on normal cells,which is a potential candidate for the development of novel therapeutics towards cancer.

关键词： Syringic acid Copper Iron cancer cell Pro-oxidant Autophagy

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One Step Quick Detection of cancer cell Surface Marker by Integrated NiFe-based Magnetic Biosensing cell Cultural Chip

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Nano-Micro Letters 2013年第3期5卷 213-222页

作者： Chenchen Bao Lei Chen Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University FOCAS Research Institute Dublin Institute of Technology

RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiF e-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiF e-based magnetic biosensing chip and distinguish the amount of cell surface *** lines such as Calu3, Hela, A549, CaF br, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost,easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition.

关键词： Magnetic impedance cancer cell Targeted detection Biosensing system cell cultural chip

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A novel inhibitor of N6-methyladenosine demethylase FTO induces mR NA methylation and suppresses cancer cell malignancy

A novel inhibitor of N6-methyladenosine demethylase FTO indu...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Guoyou Xie Yuyi Ling Wu XuNian Rui Yalan Sun Yat-sen University

N6-methyladenosine(m6 A) modification is critical for RNA splicing, nuclear export, stability and translation. FTO(fat mass and obesity-associated protein), the first identified m6 A demethylase, is critical for cancer progression, lipogenesis, and virus infection. Herein, we discovered small-molecule inhibitors of FTO by virtual screening, structural optimization, and bioassay. As a result, two FTO inhibitors namely 18077 and 18097 were identified, which can selectively inhibit demethylase activity of FTO. 18097 can competitively bind to the active site of FTO to further inhibit the malignancy of cancer cells, including blocking the cell cycle and inhibiting migration and invasion. In addition,18097 reprogrammed the epi-transcriptome of cancer cells, especially genes related to the P53 pathway. Among them, 18097 can increase the binding of suppressor of cytokine signaling 1(SOCS1)mRNA to IGF2 BP1 by increasing the abundance of m6 A modification of SOCS1 mRNA, leading to the stability of SOCS1 mRNA and the activation of the P53 pathway. Further, 18097 can suppress cellular lipogenesis via suppression of PPARγ, C/EBPα, and C/EBPβ. Animal and clinical studies confirmed that the inhibition of FTO can significantly suppress in vivo lung colonization of breast cancer cells and we have also confirmed that 18091 has this effect in animal. Collectively, we identified that FTO can work as a potential drug target and small-molecule inhibitor 18097 of FTO can serve as a potential agent against cancer.

关键词： m6A FTO inhibitors cancer cell lipogenesis SOCS1

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Size and shape-dependent peroxidase-like catalytic activity of MnFe2O4 Nanoparticles and their colorimetric detection of target cancer cell

Size and shape-dependent peroxidase-like catalytic activity ...

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中国化学会第九届全国无机化学学术会议

作者： Yunhua Peng Zhiyi Wang Weisheng Liu Fengjuan Chen Baodui Wang Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry Lanzhou University Gansu Department of gynaecology and obstetrics Lanzhou University Second Hospital

Nanomaterials with enzyme-like activity have received considerable attention over the past few decades because of their unique size, shape, composition and structure-dependent properties. Generally, the catalytic activity of nanocrystal catalysts depends strongly on their chemical composition, size, and shape. As an important transition-metal oxide, Mn Fe2O4 nanoparticles exhibit enhanced peroxidase-like activity. However, there have been few attempts to investigate the catalytic properties of peroxidase nanomimetics with different size and shape and little is known about the effects of different size and shape on biocatalysis with Mn Fe2O4. Herein, we report four different size and shape of Mn Fe2O4 nanoparticles（NPs） prepared by a hydrothermal procedure. Additionally, the size and shape- dependent peroxidase-like activity of these NPs was first explored by using 3,3’,5,5’-tetramethyl-benzidine and H2O2 as peroxidase substrates. The results showed that the peroxidase-like activities of the Mn Fe2O4 NPs were size and shape- dependent and followed the order of 4 nm（spherical）＞ 18 nm（plate-like）＞ 27 nm（near-cubic）＞ 16nm（spherical）;this order was closely related to their surface-to-volume ratio and atom arrangement manners. This suggests that selective fabrication of peroxidase nanomimetics with different size and shape is very important to harness their catalytic activities. In addition FA- and FITC-conjugated Mn Fe2O4 NPs can be employed in colorimetric detection and imaging of target cancer cells. Moreover, this assay possesses excellent specificity and sensitivity for the detection of clinically important target breast cancer cells. Our work will facilitate the mechanistic understanding and technological applications of peroxidase nanomimetics for biotechnology, environmental chemistry, and medicine.

关键词： peroxidase-like catalytic activity magnetic nanoparticle colorimetric detection cancer cell imaging

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cancer cell:“合成致死”治肿瘤又有新进展

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现代生物医学进展 2015年第35期 7003-7004页

众所周知基因突变会驱动癌细胞生长,并促进癌细胞对治疗方法和药物的抵抗。但是这些基因突变也可以变成肿瘤细胞的致命弱点,牛津大学的一个研究团队发现在一个叫做SETD2的基因上发生的突变可能会对癌细胞造成致命损伤。相关研究结果发... 详细信息

众所周知基因突变会驱动癌细胞生长,并促进癌细胞对治疗方法和药物的抵抗。但是这些基因突变也可以变成肿瘤细胞的致命弱点,牛津大学的一个研究团队发现在一个叫做SETD2的基因上发生的突变可能会对癌细胞造成致命损伤。相关研究结果发表在国际学术期刊cancer cell上。本文作者Dr Timothy Humphrey表示,SETD2基因上发生的突变经常出现于肾脏癌症以及一些儿童脑瘤中,而他们在研究过程中发现了一种新药物能够特异性杀伤携带这种基因突变的癌细胞。

关键词：儿童脑瘤基因突变特异性点突变癌细胞 cancer cell

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cancer cell:我国科学家有望开发出治疗急性髓性白血病的新疗法

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现代生物医学进展 2017年第6期17卷 1201-1202页

近日,刊登在国际杂志cancer cell上的ー项研究报告中,来自上海交通大学医学院等机构的研究人员通过研究发现了治疗急性髓性白血病(AML)的新型治疗靶点和新型疗法,急性髓性白血病是ー种血液骨髓癌症,通常需要及时且积极的疗法对这种癌症... 详细信息

近日,刊登在国际杂志cancer cell上的ー项研究报告中,来自上海交通大学医学院等机构的研究人员通过研究发现了治疗急性髓性白血病(AML)的新型治疗靶点和新型疗法,急性髓性白血病是ー种血液骨髓癌症,通常需要及时且积极的疗法对这种癌症进行治疗。研究者Wei Jia博士指出,目前我们急需新型靶点和药物来改善急性髓性白血病患者的预后情况而且我们发现患者机体中果糖的使用水平会增加,这种特殊的代谢特性就能够帮助预测患者的治疗预后情况,这项研究还为研究者提供了强大的证据来表明,利用小分子药物阻断机体果

关键词：髓性白血病新疗法 cancer cell

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cancerous cell viability affected by synergism between electric pulses and a low dose of silver nanoparticle:An adaptive neuro-fuzzy inference system

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Medicine in Novel Technology and Devices 2024年第1期21卷 45-52页

作者： Salim Mirshahi Behzad Vahedi Kiarash Aryana Ameneh Sazgarnia Department of Mechanical Engineering Sharif University of TechnologyTehranIran Medical Physics Research Center Mashhad University of Medical SciencesMashhadIran Functional Neurosurgery Research Center Shohada Tajrish Comprehensive Neurosurgical Center of ExcellenceShahid Beheshti University of Medical SciencesTehranIran Department of Mechanical Engineering Ferdowsi University of MashhadMashhadIran

In the current study,applying simultaneously electroporation and silver nanoparticles(SNPs)are ***,one restriction normally assigned to such nanoparticles is their side effects on the vital organs of the *** mitigate such deleterious effects,it is better to use lower dosages of ***,this can result in a decline in the technique's *** compensate for the lower dose of SNPs,one can use secondary method like electroporation to deliver SNPs directly into the cells and reinforces the effect of electric pulses due to the high electrical conductivity of SNPs while having a minimal cytotoxicity effect on normal cells that are not treated with *** the present study,synergism effects of both procedures(SNPs and electroporation)experimentally and theoretically are considered to investigate the property of each technique in increasing the performance with respect to both procedures'*** investigate more,adaptive neuro-fuzzy inference system(ANFIS)is used to predict the percent cell viability of cancerous cells affected by both procedures by considering amplitude and duration as inputs affecting on change of cell viability as an *** results obtained from both experimental and simulation procedures showed that the maximum synergism between nanoparticles and electric pulses was recorded at 700V/cm strength and 100μs ***,Results indicated high correlation between observed and predicted data(r2=0.88).Moreover,the calculated root mean square error for the results of the ANFIS model was equal to *** implies that the model has practical value and can estimate the percent cell viability of cancerous cells influenced by both procedures with varying electric field amplitude and *** method can be proposed for other biophysical or drug delivery applications to save time and resources by utilizing the previous experimental data rather than performing more experiments.

关键词： Electroporation cancer cell Adaptive neuro-fuzzy inference system Nanoparticle Drug delivery

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cancer cell:神经系统细胞是如何癌变的

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现代生物医学进展 2014年第32期 4-4页

近日,一项刊登在国际杂志cancer cell上的研究论文中,来自宾夕法尼亚大学医学院的研究人员通过研究首次揭示了大脑和神经系统中的某些细胞癌化的分子机制。这项研究由研究者Sloan-Kettering领导,他的研究团队主要对肿瘤抑制子Merlin研究... 详细信息

近日,一项刊登在国际杂志cancer cell上的研究论文中,来自宾夕法尼亚大学医学院的研究人员通过研究首次揭示了大脑和神经系统中的某些细胞癌化的分子机制。这项研究由研究者Sloan-Kettering领导,他的研究团队主要对肿瘤抑制子Merlin研究;这项研究中研究者就揭示了Merlin如何抑制肿瘤的发生,而且在细胞核内该机制也可以发生。研究者表示,未被抑制的肿瘤细胞可以通过一种核心的信号系统来增加细胞数量,这种核心系统就是

关键词：神经系统 cancer cell 细胞癌宾夕法尼亚大学医学院

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cancer cell:华人科学家发现氧化还原与肺癌新关系

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现代生物医学进展 2015年第22期 4-4页

近日,来自中科院生化所和复旦大学的研究人员在国际学术期刊cancer cell在线发表了一项最新研究进展。LKB1基因能够编码丝氨酸/苏氨酸蛋白激酶LKB1,研究发现该激酶可以调节细胞能量代谢、抑制生长增殖和维持细胞极性,而这些都是该基因... 详细信息

近日,来自中科院生化所和复旦大学的研究人员在国际学术期刊cancer cell在线发表了一项最新研究进展。LKB1基因能够编码丝氨酸/苏氨酸蛋白激酶LKB1,研究发现该激酶可以调节细胞能量代谢、抑制生长增殖和维持细胞极性,而这些都是该基因抑制肿瘤的重要机制。虽然LKB1能够调节细胞生长和能量代谢,但在非小细胞肺癌中,LKB1失活如何协调肿瘤进展与代谢之间的关系仍未可知。在该项研究中,研究人员利用KrasG 12D;Lkb1lox/lox小鼠模型进行了相关研究,发现在肺部恶性腺瘤和鳞状细胞癌中,活性氧(ROS)水平存

关键词：小细胞肺癌转分化 SCC 失活 ADC cancer cell 恶性腺瘤华人氧化还原

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cancer cell:科学家鉴别出促进乳腺癌转移的特殊基因

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现代生物医学进展 2015年第32期 6402-6402页

来自澳洲莫纳斯大学的科学家近日研究发现了一种诱发乳腺癌的新型基因,该基因可以增加肿瘤的生长并且调节乳腺癌的转移,而乳腺癌作为引发癌症女性死亡的主要原因,近年来备受科学家们关注。相关研究刊登于cancer cell杂志上,该研究或为... 详细信息

来自澳洲莫纳斯大学的科学家近日研究发现了一种诱发乳腺癌的新型基因,该基因可以增加肿瘤的生长并且调节乳腺癌的转移,而乳腺癌作为引发癌症女性死亡的主要原因,近年来备受科学家们关注。相关研究刊登于cancer cell杂志上,该研究或为后期开发靶向作用早期乳腺癌的新型疗法提供新的思路。研究者Christina Mitchell说道,这种基因名为富含脯氨酸的肌醇多磷酸5-磷酸酶(PIPP),本文研究为我们开发抑制乳腺癌发展的新型策略、

关键词：乳腺癌患者癌症女性 cancer cell 后期开发早期乳腺癌基因

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