检索结果-南通市图书馆

检索条件"主题词=cancer immunotherapy"

共 153 条记录，以下是151-160 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors

4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibit...

引用

第十一届全国化学生物学学术会议

作者： Yang Chen Junlin He Fei Wang Yuzhi Li Shan Qian Department of Pharmaceutical Engineering Xihua University Pharmacy College Chengdu University of Traditional Chinese Medicine Chengdu Institute of Biology Chinese Academy of Sciences

Indoleamine 2,3-dioxygenase 1（IDO1） and tryptophan 2,3-dioxygenase（TDO） are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions[1]. A series of 4,6-substituted-1 H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships（SARs） [2-4]. Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 μM in an enzymatic assay and 1.37 μM in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INFγ-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 μM in the enzymatic assay and 7.54 μM in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1 H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.

关键词： Indoleamine 2,3-dioxygenase 1(IDO1) Tryptophan 2,3-dioxygenase(TDO) 1H-Indazoles Dual inhibitor cancer immunotherapy Antitumor activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Solubility-enhanced gMYL6 by incorporation of a hexa-lysine tag promotes the cytotoxicity of human NK cells

Solubility-enhanced gMYL6 by incorporation of a hexa-lysine ...

引用

第十二届全国免疫学学术大会

作者： Liu Juanjuan Yang Zhaoyong Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences

Current NK cell-based cancer immunotherapy is an effective treatment for patients with various *** NK cells play an increasingly important role in tumor immunotherapy in recent *** myosin 1 ight chain 6(gMYL6),an active constituent of certain immunization-induced goat anti-cancer bioactive peptides(ACBPs),was biochemically purified and identified as a7,000 Da ***,it is a myth about the role of gMYL6 in NK cell *** the complicated extraction process and low yield of gMY16 from the raw particularly immunization-induced goat ACBPs,we developed a convenient approach using Nano-flow Liquid Chromatography in tandem with Orbitrap Mass Spectrum to identify gMYL6 and constructing a C-terminal polycationic tag expression strategy to obtain and enrich solubility-enhanced gMYL6 for subsequent bioactivity ***,we identify an essential role for recombinant gMYL6 in the up-regulation of human NK cell *** a result,we got a solubility-enhanced protein,gMYL6-6K,retaining and improving its capacity of promoting the cytotoxicity of NK cells against tumor *** study opens a door for screening the other particularly immunization-induced goat bioactive proteins/peptides as a novel cytokines against cancer via activating/promoting NK cells’ *** broadly,such information might present new opportunities for boosting NK cell cytotoxicity in cancer immunotherapy.

关键词： cancer immunotherapy natural killer cell goat myosin light chain 6 heterogeneous peptide

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The expression and immunoregulation of immune checkpoint molecule VISTA in autoimmune diseases and cancers

The expression and immunoregulation of immune checkpoint mol...

引用

第十四届全国免疫学学术大会

作者： Na Li Shan ru Yang Xin Hou Fuyan Wang Jingjun Xing Mengjie Yang Yuanyuan Wang Shasha Guo Geng Wang Ningbo University 哈尔滨医科大学

Immune checkpoint inhibitors(ICIs) and immunotherapy have proven to be a transformative therapy for many forms of cancer *** many antibodies targeting the PD-1,PD-L1,and CTLA-4 pathways have been approved for clinical use by the FDA,it is clear that a single ICI is not sufficient to eradicate *** combination strategies are being extensively investigated to advance cancer treatment to next curative *** the immune checkpoint inhibitors being actively investigated,the potential of VISTA(V-domain Ig suppressor of T cell activation),a unique B7 family member that functions as both ligand and receptor,is being actively *** article summarizes the expression and immunomodulatory effects of VISTA in autoimmune diseases and cancer,and assesses its potential as an additional component of immune checkpoint cancer therapy.

关键词： VISTA Autoimmune diseases cancer immunotherapy combination therapy immune checkpoint inhibitor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共16页 << < 7 8 9 10 11 12 13 14 15 16 > >> 跳转到页

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：