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Food emulsifier glycerin monostearate aggravates phthalates'testicular toxicity by disrupting tight junctions'barrier function in rats

引用

Food Quality and Safety 2021年第2期5卷 179-187页

作者： Lingzi Xia Min Yang Miao He Mingzhe Jiang Chang Qin Zhijun Wei Haitao Gao Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina

Objectives:This study aimed to investigate the effect of the widely used food emulsifier glycerin monostearate(GM)on testicular toxicity caused by the mixture of three commonly used phthalate esters(MPEs)in rats,and further to explore the underlying *** and Methods:Thirty male Sprague-Dawley rats were randomly divided into three *** were orally treated with 160 mg/kg/d MPEs in the MPEs group;coinstantaneously treated with 160 mg/kg/d MPEs and 200 mg/kg/d GM in the MPEs+GM group;and treated with the excipient in the control *** intervention lasted for 5 *** weight,epididymis weight,testicular histopathology,and serum testosterone were detected for testicular toxicity *** testicular ultrastructure,the tight junction proteins zonula occluden(ZO)-1,and claudin were measured for the mechanism ***:The body weight,epididymis,serum testosterone level,and anogenital distance in the MPEs+GM group were significantly decreased compared with control group(P<0.05);Testicular histopathological observation showed that shed spermatids were observed in the MPEs+GM *** observation of testicular cells showed that the cristae number was decreased in some mitochondria in the MPEs group,whereas the cristae were fused and disappeared in most mitochondria in the MPEs+GM *** tight junctions were broken in the MPEs+GM group;meanwhile,the expression of ZO-1 and claudin were altered in the MPEs+GM group(P<0.01).Conclusions:The results from this study indicated that GM aggravated MPEs'testicular toxicity,which might relate to the injured mitochondria and damaged tight junctions in testicular tissue.

关键词： Glycerin monostearate butyl benzyl phthalate dibutyl phthalate di(2-ethylhexyl)phthalate male reproductive toxicity tight junction

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