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Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions

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World Journal of Gastroenterology 2000年第1期6卷 84-88页

作者： Zhu L Yang ZC Li A Cheng DC Institute of burn Research Southwest HospitalThird Military Medical UniversityChongqing 400038China Critical Care Department Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences(CAMS)Beiling 100730China

AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in *** A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within *** The gastric acid production in theacute shock period was markedly inhibited aftersevere burn *** the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(Pburns,consistent with the trend ofgastric acid production *** Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some ***,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment.

关键词： Subject headings gastric mucosal lesions gastric acid burn shock

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Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes

Lactosyl derivatives function in a rat model of severe burn ...

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中国病理生理学会受体和信号转导专业委员会暨消化专业委员...

作者： Zhihui Zhao Qing Li Jiale Hu Zhongjun Li Jinghua Liu Aihua Liu Peng Deng Lin Zhang Xiaowei Gong Kesen Zhao Shuangquan Zhang Yong Jiang Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology,College of Life Science,Nanjing Normal University,Nanjing 210046,China Key Laboratory for Functional Proteomics of Guangdong Province,Department of Pathophysiology,Southern Medical University,Guangzhou 510515,China State Key Laboratory of Natural and Biomimetic Drugs,Department of Chemical Biology,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China #Department of Surgery,Naval Hospital No.411 of PLA,Shanghai 200081,China.

＜正＞Severe bum shock remains an unsolved clinical problem with urgent needs to explore novel therapeutic *** this study,the in vivo bioactivity of a series of synthetic lactosyl derivatives （oligosacchaddes） was assessed on rats with burn shock to elucidate the underlying mechanisms. Administration of An-2 and Gu-4,two lactosyl derivatives with bi- and tetravalentβ-D-galactopyranosyl-（1,4）-β-D-glucopyranosyl ligands,significantly prolonged the survival time （P＜0.05 ***）,stabilized blood pressure and ameliorated the injuries to vital organs after *** chamber assay displayed that An-2 and Gu-4 markedly decreased the adhesion of leukocytes to microvessel endothelial *** binding assay showed that a CDllb antibody significantly interrupted the interaction of An-2 and Gu-4 with leukocytes from rats with bum *** fluorescent microscopy,we further found that the oligosaccharides were selectively bound to leukocytes and with a colocalization of CD11b on the cell ***,the lectin domain-deficient form of CD11 b failed to bind with An-2 and *** results suggest that both An-2 and Gu-4 significantly inhibit the adhesion of leukocytes to endothelial cells by binding to CDI Ib and thereby exert protective effects on severe bum shock.＜正＞Severe bum shock remains an unsolved clinical problem with urgent needs to explore novel therapeutic *** this study,the in vivo bioactivity of a series of synthetic lactosyl derivatives （oligosacchaddes） was assessed on rats with burn shock to elucidate the underlying mechanisms. Administration of An-2 and Gu-4,two lactosyl derivatives with bi- and tetravalentβ-D-galactopyranosyl-（1,4）-β-D-glucopyranosyl ligands,significantly prolonged the survival time （P＜0.05 ***）,stabilized blood pressure and ameliorated the injuries to vital organs after *** chamber assay displayed that An-2 and Gu-4 markedly decreased the adhesion of leukocytes to microvessel endothelial cells.

关键词： leukocyte-endothelial cell interaction adhesion molecule oligosaccharide integrin burn shock

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Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism,adrenergic stress and hypothalamic regulation-a systematic review

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burns & Trauma 2022年第1期10卷 272-282页

作者： Viktoria Mertin Patrick Most Martin Busch Stefan Trojan Christian Tapking Valentin Haug Ulrich Kneser Gabriel Hundeshagen Department of Hand Plastic and Reconstructive SurgeryBurn Trauma CenterBG Trauma Center LudwigshafenUniversity of Heidelberg67071 Ludwigshafen am RheinGermany Division of Molecular and Translational Cardi-ology Department of Internal MedicineⅢUniversity Hospital Heidelberg69120 HeidelbergGermany Deutsches Zentrum für Herz-und Kreislaufforschung(GCCR) Partner site Heidelberg/MannheimGermany Department of Anesthesiology and Intensive Care Medicine Merheim Medical CenterHospitals of CologneUniversity of Witten/Herdecke51109 CologneGermany

Background:In this systematic review,we summarize the aetiology as well as the current knowl-edge regarding thermo(dys)regulation and hypothermia after severe burn trauma and aim to present key concepts of pathophysiology and treatment *** burn injuries with>20%total body surface area(TBSA)affected commonly leave the patient requiring several surgical procedures,prolonged hospital stays and cause substantial changes to body composition and metabolism in the acute and long-term *** in severely burned patients,the loss of intact skin and the dysregulation of peripheral and central thermoregulatory processes may lead to substantial ***:A systematic and protocol-based search for suitable publications was conducted fol-lowing the PRISMA *** were screened and included if deemed *** encompasses animal-based in vivo studies as well as clinical studies examining the control-loops of thermoregulation and metabolic stability within burn patients Results:Both experimental animal studies and clinical studies examining thermoregulation and metabolic functions within burn patients have produced a general understanding of core concepts which are,nonetheless,lacking in *** describe the wide range of pathophysiological alterations observed after severe burn trauma and highlight the association between thermoregulation and hypermetabolism as well as the interactions between nearly all organ ***,the current clinical standards of mitigating the negative effects of thermodysregulation and hypothermia are summarized,as a comprehensive understanding and implementation of the key concepts is critical for patient survival and long-term ***:The available in vivo animal models have provided many insights into the interwoven pathophysiology of severe burn injury,especially concerning *** offer an outlook on concepts of altered central thermoregulation from non-burn research

关键词： Animal model burn shock Hypothermia Thermoregulation Temperature management burn injury Hypermetabolism

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