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针刺研究 1989年第Z1期 231-232页

作者： Zhou Hong Department of acupuncture anestheria research, Shanghai First Tuberculosis Hospital

139 cases of don’t using adjunct drug with hand manual acupuncture anest- hesis for lobectomy since 1961-1983 in our hospital were analysed, among them11 cases (1964-1966) don’t using adjunct drug and bronchi intubate during ope-ration, all of these cases (a) the breathe<35times/Min. (b) the change of bloodpressure and pulse compared before acupuncture introduce the systolic pressure<30mmHG, pulse<30times/Min. (c) only have slight pain, were given follo-wing-visit and analysed in this article.

关键词： acupuncture bronchi analysed manual visit systolic anesthesia slight opera lease

Passive sensitization increases histamine-stimulated calcium signaling and NF-κB transcription activity in bronchial epithelial cells

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Acta Pharmacologica Sinica 2006年第6期27卷 708-714页

作者： Si JIN~(2,5)Dan TIAN~3 Jian-guo CHEN~4 Li-ping ZHU~2 Sheng-yuan LIU~2 Di-xun WANG~2 2 Department of Pathophysiology,Tongji Medical College,Huazhong University of Science and Technology Key Laboratory of Pulmonary Disease of Ministry of Health of China,Wuhan 430030,China 3 Department of Pathology,Tongji Medical College.Huazhong University of Science and Technology.Wuhan 430030,China 4 Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan China Department of Pathology Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To find out if the two aspects of asthma（chronic airway inflammation andbronchial hyperresponsiveness）are related to hypersensitivity of calcium signal-ing in bronchial epithelial ***:Porcine bronchial epithelial cells（PBEC）were divided into sensitized（S）and nonsesitized（N）*** group S,the cellswere preincubated with serum from ovalbumin sensitized guinea *** group N,the cells were preincubated with serum from nonsensitized guinea *** calcium imaging and ELISA-based NF-κ3 activity were used to evaluate thehistamine-stimulated intracellular free calcium level and NF-κB activity,***:First,0.1μmol/L histamine could induce [Ca2+]ioscillationsin PBEC of group S,but not in group ***,1/Jmol/L histamine could induce[Ca2+]ioscillations of PBEC in both group S and group *** [Ca2+]ioscillationfrequency of PBEC was significantly higher in group S than in group N,thoughthe[Ca2+]ioscillation amplitude showed no difference between the two ***,when 10 μmol/L histamine was used to stimulate PBEC a transient initialincrease followed by a sustained elevation（FSE）of [Ca2+]iwas observed in PBECin both *** amplitude of the FSE of [Ca2+]iin PBEC was significantlyhigher in group S than in group *** subsequent NF-κB activity was in accor-dance to the calcium oscillation frequency evoked by histamine,but not to ***:It was suggested that the increased sensitivity of calciumsignaling in bronchial epithelial cells might contribute to the exorbitant inflamma-tion or increased susceptibility in asthmatic airway epithelial cells.

关键词： asthma histamine calcium signaling bronchi epithelial cell nuclear factor of kappaB

Induction of mucin secretion from human bronchial tissue and epithelial cells by rhinovirus and lipopolysaccharide

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Acta Pharmacologica Sinica 2004年第9期 74-79页

作者： Shao-heng HE, Jian ZHENG, Ming-ke DUANAllergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China

AIM: To examine the effects of rhinovirus and lipopolysaccharide (LPS) on mucin secretion from bronchial tissue and epithelial cells in vitro. METHODS: Human small bronchial tissue fragments (HSBTF) and human bronchial epithelial cells (HBEC) were cultured with rhinovirus 16 and LPS, respectively and culture supernatants were collected for mucin measurement. To determine mucin levels in the culture supernatants, a MUC5AC enzyme linked immunosorbent assay and an enzyme linked lectin assay procedure with dolichos biflorus agglutinin (DBA) were developed, and mucin release was expressed as percentage increased (or decreased) secretion over baseline level. RESULTS: A concentration-dependent release of DBA mucin and MUC5AC mucin were observed when HSBTF were infected with various concentrations of rhinovirus 16 at 37℃. The maximum-induced DBA mucin and MUC5AC mucin release were approximately 258 % and 83 % over baseline. The response of HSBTF to rhinovirus was completely abolished by metabolic inhibitors. Rh

关键词： rhinovirus lipopolysaccharides dolichos biflorus agglutinin mucins MUC5AC mucin bronchi epithelium human

Outcomes of surgical management of tracheobronchial injuries a case series from a developing country

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Chinese Journal of Traumatology 2011年第3期14卷 161-164页

作者： Saulat H. Fatimi Hashim M. Hanif Ameera Ahmed Ghina Shamsi Marium Muzaffar Department of Surgery Division of Cardiothoracic Surgery Aga Khan University Karachi Pakistan Medical College Aga Khan University Karachi Pakistan

Objective： Tracheobronchial injuries are defined as injuries involving the trachea and/or bronchi from the level of the cricoid cartilage extending up to the division of the bronchi. We present a case series with most of the tracheobronchial injuries found to be sustained after penetrating trauma. Methods： A retrospective review was performed at the Aga Khan University, Karachi, Pakistan. From January 2004 to December 2009, 168 patients with thoracic trauma were treated, of whom 15 were recognized to have major tracheobronchial and pulmonary injuries. Results： The average age was 3 l years with most of the patients being male （14：1）. Among them,11 patients had penetrating trauma as the main cause of injury, 3 patients had blunt trauma from road traffic accidents, only 1 patient had combined trauma （blunt and penetrating trauma）. Eightpatients were diagnosed based on radiological findings. All the patients were treated surgically. Lobectomy was the most common intervention performed in 7 patients. The mortality rate was 7% （1 patient）. Most patients survived with no sequelae （10 patients） while 5 survived with disability. We found that penetrating trauma was the leading cause of injury in our series. The severity of injury depends upon the weapon causing the trauma. Patients in our series had multiple injuries and required surgical management. Conclusions： Tracheobronchial injuries are rare but potentially life threatening. They require quick diagnosis and management. Diagnosis tends to be difficult since there are no specialised diagnostic modalities available at present.

关键词： bronchi Trachea Thoracic injuries

Effect of passive sensitization by serum from allergic asthmatic patients on the activity and expression of voltage-dependent delayed rectifier potassium channel in human bronchial smooth muscle cells

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Chinese Medical Journal 2004年第11期117卷 1630-1636页

作者：赵丽敏徐永健张珍祥倪望陈士新 Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

Background Potassium (K +) channels are important in regulating cell membrane potential and excitability. Although bronchial myocytes from asthmatic rats show a significant reduction in voltage-dependent delayed rectifier potassium channel (Kv) current density and higher excitability, the activity and expression of Kv in human bronchial smooth muscle cells (HBSMCs) have never been studied. The ob jective of this study was to investigate the effect of passive sensitization by asthmatic serum on the activity of Kv and the expression of Kv isoform Kv1.5 in *** HBSMCs were randomly divided into two groups: control group (containing 10% serum from nonatopic individuals) and sensitized group (containing 10% asthmatic serum), then cultured for 24 hours. Whole-cell patch clamp, immunofluorescence staining, reverse transcription-polymerase chain reaction and Western blot techniques were used to study the effect of passive sensitization on the activity of Kv and the expression of Kv1.5 in *** The membrane potential in passively sensitized HBSMCs was significantly depolarized to -(26.7±5.2) mV compared with -(41.3±6.4) mV in the cont rol group (P<0.01). Passive sensitization caused a significant inhibition of Kv currents in HBSMCs, resulting in a downward shift in the current-voltage (Ⅰ-Ⅴ) relationship curve. At +50mV, the peak Kv current density of passively sensitized HBSMCs was significantly decreased from (54.6±8.7) picoamperes per picofarad ( pA/pF) to (32.1±7.1) pA/pF (P<0.01). The expression level of Kv1.5 mRNA in passively sensitized HBSMCs was significantly lower than that in the control group (0.76±0.07 vs 1.04±0.13, P<0.05). The expression of Kv1.5 protein of passively sensitized HBSMCs was also significantly reduced compared to that from the control group (984±168 vs 2200±380, P<0.05).Conclusions The activity and expression of Kv were all decreased in HBSMCs passively sensitized by asthmatic serum compared with nonsensitized cells. T

关键词： bronchi myocytes smooth muscle voltage-dep endent delayed rectifier potassium channel passive sensitization

Consecutive allergen challenges resulted in decreased bronchial responsiveness

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Chinese Medical Journal 2002年第11期115卷 1727-1729,156页

作者：贺建新江载芳首都医科大学附属北京儿童医院呼吸科北京100045

OBJECTIVE: To investigate bronchial responsiveness to acetylcholine in allergic airway inflammation of SD rats. METHODS: SD rats were immunized and challenged by chicken ovalbumin (OVA). Airway responsiveness, acetylcholine (Ach) provocation concentration needed to increase baseline airway resistance by 200% (PC(200)) were measured. RESULTS: The value of baseline airway resistance in asthma group was significantly higher than that in control group (2.282 +/- 0.128 vs 3.193 +/- 0.239; P

关键词： Acetylcholine Airway Resistance Allergens Animals bronchi bronchial Hyperreactivity Bronchoconstriction Lung Male Ovalbumin Rats Rats, Sprague-Dawley

Pulmonary nodules: optimal slice thickness of CT in revealing bronchial imageology

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The Chinese-German Journal of Clinical Oncology 2011年第11期10卷 626-631页

作者： Shenjiang Li Changcheng Li Xing Wang Debin Liu Wenjie Liang Feng Zhu Yan Zhu Xuefeng Cui Fangang Hu Yuanyuan Wang Department of Imageology The Eighty-eighth Military Hospital Tai＇an 271000 China

Objective： The aim of our study was to determine an optimal slice thickness that was efficient in revealing bronchial imageology of pulmonary nodules （PNs） on multi-slice spiral computed tomography （MSCT） images preliminarily. Methods： Fifty-four patients with 62 PNs （diameter 〈 3 cm） underwent multidetector-row computed tomography of the chest in a single-breath-hold technique. The raw data were acquired with a collimation of 0.625 mm. Three sets of contiguous im- ages were reconstructed with 1-, 2-, and 5-mm slice thickness, respectively. bronchial imageology of SPNs on the CT images presented in 1-, 2-, and 5-mm slice thickness was compared. Using the 1-mm sections as the gold standard, an optimal slice thickness in revealing bronchial imageology of PNs was determined. Results： bronchial imageology of PNs on the CT images presented in 1 mm slice thickness involved 85 bronchi （35 second-fourth generation bronchi; 50 fifth-eighth generation bronchi）. bronchial imageology on 2-mm-thick sections was as same as that on I-mm-thick sections in 34 second- fourth generation bronchi. No statistically significant difference in number of second- fourth generation bronchi with same bronchial imageology was found between that on 2-mm-thick images and I-mm-thick images （P = 0.836 〉 0.05）. bronchial imageology on 5-mm-thick sections was as same as that on 1-mm-thick sections in 24 second-fourth generation bronchi. There was statistically significant difference in number of second-fourth generation bronchi with same bronchial imageology between that on 5-mm-thick images and 1-mm-thick images （P = 0.026 〈 0.05）. bronchial imageology on 2-mm-thick sections was as same as that on 1-mm-thick sections in 38 fifth-eighth generation bronchi. There was statistically significant difference in number of fifth-eighth generation bronchi with same bronchial imageology between that on 2-mm-thick images and 1-mm- thick images （P = 0.029 〈 0.05）. bronchial imageology on 5-mm-thick images was as

关键词： tomography, X-ray computed Coin lesion, pulmonary bronchi

Pulmonary-bronchus myelolipoma and review on extra-adrenal myelolipomas in Chinese literature

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Chinese Medical Journal 2012年第17期125卷 3188-3190页

作者： HUANG Wen-ting ZHAO Shi-jun LIN Dong-mei Department of Pathology Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China Department of Diagnostic Radiology Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China

Extra-adrenal myelolipomas are extremely rare, especially in bronchus and lung. Up to now, only nine cases of intra pulmonary lesions have been reported all over the world. Here we describe a new discovered pulmonary-bronchus myelolipoma in a 53-year-old man, which is different from the previously reported ones. And we mainly comment on the pathology and diagnosis, comparing with the findings of the extra-adrenal cases reported in Chinese literature.

关键词： myelolipoma lung bronchi pathology

Analysis of Mortality Rates of the 5 Most Frequent Primary Cancer Sites in Brazil between 1979 and 2015 for Both Sexes

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Journal of Pharmacy and Pharmacology 2019年第2期7卷 61-68页

作者： Luiz Carlos de Araujo Souza Hugo Oliveira de Figueiredo Cavalcanti Vinicius Carvalhedo Cunha Sandra Lucia Branco Mendes Coutinho Undergraduates of Medicine in the University Center of Brasilia(UniCEUB)and Researchers in the Department of Cytopathology and Pathological Anatomy of the Base Institute of the Federal District(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Resident Physician in Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil Physician Anatomopathologist and Head of the Department of Cytopathology and Anatomical Pathology of the Federal District Base Institute(NUCAP-IHBDF) Hospital Medical Sector Sul-Asa SulBrasilia 70330-150Brazil

Introduction:Global estimates determined that there would be 14.1 million new cases of cancer and 8.2 million deaths from ***:To determine the adjusted mortality rates of the 5 most frequent primary sites of cancer and the mortality rates of the 5 most frequent primary in Brazil,between 1979 and ***:Epidemiological study between 1979 and 2015 based on data obtained from the Online Atlas of Mortality provided by the National Cancer Institute of Brazil(INCA)using information on cancer deaths obtained within the System of Information on Mortality(SIM)of Brazil Ministry of ***:When analyzing the mortality rate of the 5 most frequent primary sites by type of cancer from 1979 to 2015 for both sexes,we show that in the year 2015 the cancers with the highest rates are:bronchi and lungs,breast,stomach,prostate and unknown primary location.A total of 527,980 deaths from bronchial and lung neoplasms were recorded,304,546 deaths from breast cancer were recorded,407,611 deaths from stomach cancer were recorded,268,061 deaths from prostate cancer were recorded,and 257,357 deaths due to neoplasia of unknown primary location were *** we analyze the world standard rate and Brazil’s standard rate for mortality,we show that Brazil has higher values for the 5 most frequent primary sites by type of ***:The epidemiological study of these values aims to determine what are the main descriptors and characteristics to determine preventive measures against the increase of this disease.

关键词： Cancer bronchi breast stomach prostate unknown primary location Brazil INCA

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Respiratory System

China Medical Abstracts(Internal Medicine) 2015年第1期32卷 36-43页

2015075 A study on the cooperation between centers for disease control and special tuberculosis hospitals for treatment and management of multi-drug resistant *** Renzhong(李仁忠),et *** Drug-resistant Tuberc,Nat Tuber Contr&Prev *** *** J Tuberc Respir Dis2014;37(10):*** To improve the effectiveness of case detection and treatment of multi-drug resistant tuberculosis(MDR-TB)by implementing a mechanism of

关键词： cooperation Tuberc 李仁忠 tuberculosis bronchi subgroup producing cough aspergillosis saline