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Bruch's membrane opening-minimum rim width and visual field loss in glaucoma:a broken stick analysis

International Journal of Ophthalmology(English edition) 2018年第5期11卷 828-834页

作者： Keun-Heung Park Ji-Woong Lee Jin-Mi Kim Kouros Nouri-Mahdavi Joseph Caprioli Department of Ophthalmology Pusan National University College of Medicine Biomedical Research Institute Pusan National University Hospital Department of Biostatistics Clinical Trial CenterBiomedical Research InstitutePusan National University Hospital Stein Eye Institute David Geffen School of Medicine at UCLA

AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become ***：A total of 85 normal subjects and 83 glaucoma patients（one eye per participant） were recruited for the *** of the patients had VF examinations and spectral-domain optical coherence tomography to measure the *** deviation values for 52 VF points were allocated to the corresponding sector according to the Garway-Heath distribution *** evaluate the relationship between VF loss and BMOMRW measurements,a ＂broken-stick＂ statistical model was *** tipping point where the VF values started to sharply decrease as a function of BMO-MRW measurements was estimated and the slopes above and below this tipping point were ***：A 25.9% global BMO-MRW loss from normative value was required for the VF loss to be ***,substantial BMO-MRW thinning in inferotemporal sector（33.1%） and relatively less BMO-MRW thinning in the superotemporal sector（8.9%） were necessary for the detection of the VF *** the tipping point,the slopes were close to zero throughout all of the sectors and the VF loss was unrelated to the BMO-MRW *** VF loss was related to the BMO-MRW loss below the tipping *** difference between the two slopes was statistically significant（P≤0.002）.CONCLUSION：Substantial BMO-MRW loss appears to be necessary for VF loss to be detectable in patients with open angle glaucoma with standard achromatic perimetry.

关键词： Bruch's membrane opening-minimum rim width visual field loss structure function relationship broken stick model optical coherence tomography

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