检索结果-南通市图书馆

检索条件"主题词=breviscapinun"

共 3 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Therapeutic Time Window and Underlying Therapeutic Mechanism of breviscapinun Injection against Cerebral Ischemia/Reperfusion Injury in Rats

Therapeutic Time Window and Underlying Therapeutic Mechanism...

引用

第十五届中国科协年会第21分会场：中药与天然药物现代研究学术研讨会

作者： GUO Chao ZHU Yanrong QUAN Wei YIN Ying Xi Miaomiao ZHOU Dan WEN Aidong Fourth Military Medical University

Our study was designed to investigate the therapeutic time window and underlying therapeutic mechanism of breviscapinun injection against cerebral ischemic / reperfusion injury. In the present study, Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 2 h. Rats were intravenous injected with 40 mg/kg breviscapinun injection at different time-points and the same doses were administered every 24 h for 3 consecutive days. After 72 h of reperfusion, neurologic scores, infarct volume and the levels of neuron-specific enolase were measured in a masked fashion. To explore the role of HIF-1α in the neuroprotective effects of breviscapinun injection, immunohistochemistry and western blot analysis in a separate study were performed after 3 and 24 h of reperfusion. Treatment with breviscapinun significantly ameliorated neurologic deficit, reduced infarct volume and suppressed the NSE levels in a time-dependent manner. Moreover, treatment with breviscapinun increased the expression of HIF-1α protein at 3 and 24 h after reperfusion. These results suggest that the therapeutic time window of breviscapinun injection for cerebral ischemia / reperfusion injury seem to be within 5 h after reperfusion, and by increasing the expression of HIF-1α may be involved in the therapeutic mechanism of breviscapinun.

关键词： breviscapinun ischemia/reperfusion therapeutic time window hypoxia-inducible factor-1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Therapeutic Time Window and Underlying Therapeutic Mechanism of breviscapinun Injection Against Cerebral Ischemia/Reperfusion Injury in Rats

Therapeutic Time Window and Underlying Therapeutic Mechanism...

引用

第十二届全国青年药学工作者最新科研成果交流会

作者： GUO Chao ZHU Yan Rong QUAN Wei YIN Ying Xi Miao Maio ZHOU Dan WEN Ai Dong Department of Pharmacy Xijing HospitalFourth Military Medical University

Aim of this study:Our study was designed to investigate the therapeutic time window and underlying therapeutic mechanism of breviscapinun injection against cerebral ischemic / reperfiision ***:In the present study,Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 2 *** were intravenous injected with 40 mg/kg breviscapinun injection at different time-points and thersame doses were administered every 24 h for 3 consecutive *** 72 h of reperfusion,neurologic scores,infarct volume and the levels of neuron-specific enolase were measured in a masked *** explore the role of HIF-la in the neuroprotective effects of breviscapinun injection,immunohistochemistry and western blot analysis in a separate study were performed after 3 and 24 h of ***:Treatment with breviscapinun significantly ameliorated neurologic deficit,reduced infarct volume and suppressed the NSE levels in a time-dependent ***,treatment with breviscapinun increased the expression of HIF-1α protein at 3 and 24 h after ***:These results suggest that the therapeutic time window of breviscapinun injection for cerebral ischemia / reperfusion injury seem to be within 5 h after reperfusion,and by increasing the expression of HIF-1αmay be involved in the therapeutic mechanism of breviscapinun.

关键词： breviscapinun Ischemia/reperfusion Therapeutic time window Hypoxia-inducible factor-1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Therapeutic Time Window and Underlying Therapeutic Mechanism of breviscapinun Injection Against Cerebral Ischemia/Reperfusion Injury in Rats

Therapeutic Time Window and Underlying Therapeutic Mechanism...

引用

2015年中国药学大会暨第十五届中国药师周

作者： GUO Chao ZHU Yan Rong QUAN Wei YIN Ying Xi Miao Maio ZHOU Dan WEN Ai Dong Department of Pharmacy Xijing Hospital Fourth Military Medical University

Aim of this study: Our study was designed to investigate the therapeutic time window and underlying therapeutic mechanism of breviscapinun injection against cerebral ischemic/reperfusion injury. Methods: In the present study, Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 2 h. Rats were intravenous injected with 40 mg/kg breviscapinun injection at different time-points and the same doses were administered every 24 h for 3 consecutive days. After 72 h of reperfusion, neurologic scores, infarct volume and the levels of neuron-specific enolase were measured in a masked fashion. To explore the role of HIF-1α in the neuroprotective effects of breviscapinun injection, immunohistochemistry and western blot analysis in a separate study were performed after 3 and 24 h of reperfusion. Results: Treatment with breviscapinun significantly ameliorated neurologic deficit, reduced infarct volume and suppressed the NSE levels in a time-dependent manner. Moreover, treatment with breviscapinun increased the expression of HIF-1α protein at 3 and 24 h after reperfusion. Conclusions: These results suggest that the therapeutic time window of breviscapinun injection for cerebral ischemia/reperfusion injury seem to be within 5 h after reperfusion, and by increasing the expression of HIF-1α may be involved in the therapeutic mechanism of breviscapinun.

关键词： breviscapinun Ischemia/reperfusion Therapeutic time window Hypoxia-inducible factor-1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：