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Case Report:breast metastasis from small cell lung carcinoma

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 39-43页

作者： Shi-ping LUH Chih KUO Thomas Chang-yao TSAO Department of Surgery Chia-Yi Christian Hospital and Chung-Shan Medical University and HospitalTaichung 402TaiwanChina Department of Pathology Chung-Shan Medical University and HospitalTaichung 402TaiwanChina Department of Medicine Chung-Shan Medical University and HospitalTaichung 402TaiwanChina

breast metastases from extramammary neoplasms are very rare. We presented a 66 year-old female with metastasis of small cell lung carcinoma to the breast. She presented with consolidation over the left upper lobe of her lung undetermined after endobronchial or video-assisted thoracoscopic surgery (VATS) biopsy,and this was treated effectively after antibiotic therapy at initial stage. The left breast lumps were noted 4 months later,and she underwent a modified radical mastectomy under the im-pression of primary breast carcinoma. However,the subsequent chest imaging revealed re-growing mass over the left mediastinum and hilum,and cells with the same morphological and staining features were found from specimens of transbronchial brushing and biopsy. An accurate diagnosis to distinguish a primary breast carcinoma from metastatic one is very important because the therapeutic planning and the outcome between them are different.

关键词： Small cell carcinoma breast metastasis Lung

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Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 209-211页

作者： Pankaj Kumar Garg Nita Khurana Niladhar S Hadke Department of Surgery Maulana Azad Medical College and Lok Nayak Hospital Department of Pathology Maulana Azad Medical College and Lok Nayak Hospital

BACKGROUND:Though gallbladder carcinoma is asso- ciated with early lymphatic and hematogenous spread, the only common extra-abdominal site of metastasis is *** carcinoma metastasizing to breast and subcutaneous tissue is not known. METHOD:This report describes an interesting and unusual case of asymptomatic gallbladder carcinoma presenting with subcutaneous and breast metastasis. RESULTS:A 42-year-old woman presented with multiple subcutaneous nodules over the abdominal wall,anterior chest wall,back and in bilateral *** needle aspiration cytology(FNAC)of these nodules revealed metastatic *** patient was investigated for a primary *** ultrasound of the abdomen followed by a contrast-enhanced CT scan showed a growth in gallbladder,infiltrating the liver with multiple hepatic ***-guided FNAC from the growth in the gallbladder revealed *** was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was *** she developed jaundice and deteriorated dramatically in a short span of *** specific therapy could be started and she was given supportive *** died within three weeks of diagnosis due to hepatic encephalopathy. CONCLUSIONS:This report highlights an unusual metastasis of gallbladder carcinoma to the breast and subcutaneous tissue presenting as multiple lesions,which has never been reported in the English *** were unknown sites of metastasis for carcinoma of the ***,bilateral multiple metastatic lesions to breast are also very rare.

关键词： gallbladder carcinoma breast metastasis subcutaneous metastasis

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Successful treatment of breast metastasis from primary transverse colon cancer:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2559-2566页

作者： Xin Jiao Fang-Zhou Xing Mi-Mi Zhai Peng Sun Department of Gastrointestinal Surgery Affiliated Hospital of Weifang Medical UniversityWeifang 261041Shandong ProvinceChina Department of Digestive System Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND The incidence of colon cancer is increasing *** for colon cancer include surgery and surgery combined with chemotherapy and radiotherapy,but the median survival rate is still *** cancer most commonly metastasizes to the lymph nodes,lungs,liver,peritoneum,and brain,but breast metastasis is *** is no agreement on its *** SUMMARY A 23-year-old woman was admitted to our hospital for further treatment with a history of acute abdominal pain,nausea,and *** physical examination and computed tomography scan revealed an abdominal *** colectomy was successfully *** examination revealed that the tumor was a mucosecretory adenocarcinoma with signet ring *** patient inadvertently found a mass in the outer upper quadrant of the right breast after four cycles of XELOX chemotherapy[oxaliplatin 130 mg/m^(2),d1,intravenous(iv)drip for 2 h;capecitabine 1000 mg/m^(2),po,bid,d1–d14].After discussion with the patient,we performed a lumpectomy and frozen *** latter revealed that the breast tumor was intestinal *** testing showed wild-type RAS and *** we replaced the original chemotherapy with FOLFIRI[irinotecan 180 mg/m^(2),d1,iv drip for 3–90 min;leucovorin 400 mg/m^(2),d1,iv drip for 2 h;5-fluorouracil(5-FU)400 mg/m^(2),d1 and 5-FU 1200 mg/(m^(2)d)×2 d,continuous iv drip for 46–48 h]+cetuximab(500 mg/m^(2),d1,iv drip for 2 h).Serum levels of tumor markers returned to normal after several treatment cycles,and there was no evidence of tumor recurrence or *** breast metastasis from colon cancer is *** breast surgery should be avoided unless needed for *** combined with targeted therapy should be the first choice.

关键词： Colon cancer breast metastasis Tumor markers FOLFIRI Cetuximab Prognosis Case report

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Gastric signet-ring adenocarcinoma presenting with breast metastasis

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World Journal of Gastroenterology 2006年第18期12卷 2958-2961页

作者： Anastasios L Boutis Charalambos Andreadis Frideriki Patakiouta Despina Mouratidou 3rd Department of Clinical Oncology Theagenion Cancer HospitalThessalonikiGreece Division of Pathology Theagenion Cancer HospitalThessalonikiGreece

breast metastases from gastric cancer are extremely rare. A case report of a 37-year-old female with breast inflammatory invasion and ascites is described. breast biopsy revealed carcinomatous invasion of the lymphatics from adenocarcinoma cells with signet-ring features. Estrogen （ER） and progesterone receptors （PR） and c-erb-B2 were negative. Upper gastrointestinal endoscopy revealed a prepyloric ulcerative mass. Histopathologic examination of the lesion showed infiltration from a highgrade adenocarcinoma, identical with that of the breast. Immunostaining was positive for cytokeratins CK-7 and CK-20 and CEA and negative for ER and PR. Ascitic fluid cytology was positive for adenocarcinoma cells. Mammography was not diagnostic. Abdominal CT scanning revealed large ovarian masses suggestive of metastases （Krukenberg＇s tumor）. A cisplatin-based regimen was given but no objective response was observed. The patient died six months after initial diagnosis. A review of the literature is performed.

关键词： Gastric adenocarcinoma Signet-ring breast metastasis Ovarian metastasis

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Simultaneous breast and ovarian metastasis from gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 553-554页

作者： Sanjay Singh Puneet Gupta Rahul Khanna Ajay K Khanna Department of General Surgery Institute of Medical SciencesBanaras Hindu University

BACKGROUND:Gallbladder carcinoma is a common malignancy in the Indian *** commonly metastasizes through lymphatics,direct invasion,and hematogenous spread.A common extra-abdominal site of metastasis is the *** metastasis to breast and ovary is extremely ***:This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same ***:A 45-year-old woman came to us with complaints of flatulent dyspepsia associated with weight loss and *** of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus,but normal uterus and ***-enhanced computer tomography of the abdomen showed a gallbladder mass infiltrating the liver *** patient underwent radical *** examination revealed a poorly-differentiated adenocarcinoma with margins free from tumor *** month after surgery she developed a breast *** of the abdomen for metastatic workup revealed an ovary *** mastectomy and salphingo-opherectomy were performed,and histopathological examination revealed a metastatic *** patient is now on chemotherapy with ***:This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary,which has not been documented before.

关键词： gallbladder carcinoma breast metastasis ovary metastasis

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