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Intranasal administration nanosystems for brain-targeted drug delivery

Nano Research 2023年第12期16卷 13077-13099页

作者： Yue Jiang Xueting Pan Tao Yu Hai Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

The existence of the blood-brain barrier(BBB)restricts the entry of drugs from the circulation into the central nervous system(CNS),which severely affects the treatment of neurological diseases,including glioblastoma,Parkinson’s disease(PD),and Alzheimer’s disease(AD).With the advantage of bypassing the BBB and avoiding systemic distribution,intranasal administration has emerged as an alternative method of delivering drugs to the brain.Drug delivery directly to the brain using intranasal nanosystems represents a new paradigm for neurological disease treatment because of its advantages in improving drug solubility and stability in vivo,enabling targeted drug delivery and controlled release,and reducing non-specific toxicity.And it has shown efficacy in animal models and clinical applications.Herein,this review describes the mechanisms of intranasal delivery of brain-targeted drugs,the properties of nanosystems for intranasal administration(e.g.,liposomes,nanoemulsions,and micelles),and strategies for intranasal drug delivery to enhance brain-targeted drug delivery.Recent applications of nanosystems in intranasal drug delivery and disease treatment have been comprehensively reviewed.Although encouraging results have been reported,significant challenges still need to be overcome to translate these nanosystems into clinics.Therefore,the future prospects of intranasal drug delivery nanosystems are discussed in depth,expecting to provide useful insights and guidance for effective neurological disease treatment.

关键词： intranasal administration nanosystems brain-targeted delivery neurological diseases drug delivery

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Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities

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Chinese Chemical Letters 2023年第4期34卷 99-109页

作者： Ping Wang Yue Wang Ping Li Chen Chen Siman Ma Linxuan Zhao Haibing He Tian Yin Yu Zhang Xing Tang Jingxin Gou Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Jilin UniversityChangchun 130021China School of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

Efficient oral delivery of drugs treating brain diseases has long been a challenging topic faced by the drug delivery community. Fortunately, polyester nanoparticles offer certain solutions to this problem. This review article firstly describes the main obstacles faced by oral administered brain targeting, including:(1)instability in the gastrointestinal tract;(2) poor penetration of the intestinal mucosa and epithelium;(3)blood clearance;and(4) restriction by the BBB. Then the key factors influencing brain-targeting efficiency of orally administered polyester nanoparticles are also discussed, such as size, shape and surface properties. Finally, recent brain-targeting delivery strategies using oral polyester nanoparticles as carriers and their effects on brain drugs transport are reviewed, and the delivery ‘as a whole’ strategy of polyester nanoparticles will provide new insight for oral brain-targeting delivery. And by combination of multiple strategies, both the stability and permeability of polyester nanoparticles can be greatly improved for oral brain drug delivery.

关键词： Polyester nanoparticles Oral brain drugs brain-targeted delivery Physiological barrier Absorption enhancement

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Characteristics of sequential targeting to brain glioma for transferrin-modified cisplatin liposome

Characteristics of sequential targeting to brain glioma for ...

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

作者： Qing Lv~(1 2) Min Han~1 Fan-Zhu Li~2 Jian-Oing Gao~(1*) 1 institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China 2 College of Pharmaceutical Science Zhejiang Chinese Medical University Hangzhou 310053 China. Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058Ch Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058Ch College of Pharmaceutical Science Zhejiang Chinese Medical UniversityHangzhou 310053China.

Objective:Methods on how to improve the sequential targeting of glioma subsequent to passing of drug through the blood-brain barrier(BBB)have been occasionally reported.However,the characteristics

关键词： sequential-targeting brain-targeted delivery transferring cisplatin glioma

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