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Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury

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Asian Journal of Andrology 2008年第1期10卷 54-59页

作者： Anthony J. Bella Guiting Lin Ilias Cagiannos Tom F. Lue Department of Surgery Division of UrologyUniversity of Ottawa Ottawa KIY4E9 Canada Department of Neuroscience Ottawa Health Research Institute University of Ottawa Ottawa KIY4E9 Canada Knuppe Molecular Urology Laboratory San Francisco CA 94143 USA Department of Urology University of California San Francisco CA 94143 USA

Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves （CNs）, as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction （ED） after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors （GDNF）, bone morphogenic proteins, immunophilin ligands, erythropoetin （EPO）, and stem cells.

关键词： erectile dysfunction prostate cancer radical prostatectomy postoperative complications neuroprotection nerve regeneration neurotrophins brain-derived nerve growth factor immunophilin ligands stem cells

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Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury

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Neural Regeneration Research 2011年第10期6卷 732-737页

作者： Dongfei Li Chun Yang Rongmei Qu Huiying Yang Meichun Yu Hui Tao Jingxing Dai Lin Yuan Key Laboratory of Tissue Construction and Detection of Guangdong Province Department of Anatomy Southern Medical UniversityGuangzhou 510515 Guangdong Province China

The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function.

关键词： adipose-derived mesenchymal stem cells traumatic brain injury brain-derived nerve growth factor cortex stem cell transplantation neural regeneration

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