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Protective effects of dl-3n-butylphthalide against diffuse brain injury

Neural Regeneration Research 2013年第28期8卷 2615-2624页

作者： Yaning Zhao Jianmin Li Pan Zhang Changxiang Chen Shuxing Li College of Rehabilitation Hebei United University Affiliated Hospital of Hebei United University

DI-3n-butyiphthalide can effectively treat cerebral ischemia; however, the mechanisms underlying the effects of dl-3n-butylphthalide on microcirculation disorders following diffuse brain injury remain unclear. In this study, models of diffuse brain injury were established in Sprague-Dawley rats with the vertical impact method. DI-3n-butylphthalide at 80 and 160 mg/kg was given via intraperitoneal injection immediately after diffuse brain injury. Ultrastructural changes in the cerebral cortex were observed using electron microscopy. Cerebral blood flow was measured by laser Doppler flowmetry, vascular density was marked by tannic acid-ferric chloride staining, vascular permeability was es- timated by the Evans blue method, brain water content was measured using the dry-wet method, and rat behavior was measured by motor function and sensory function tests. At 6, 24, 48, and 72 hours after administration of dl-3n-butylphthalide, reduced cerebral ultrastructure damage, in- creased vascular density and cerebral blood flow, and improved motor and sensory functions were observed. Our findings demonstrate that dl-3n-butylphthalide may have protective effects against diffuse brain injury by ameliorating microcirculation disorder and reducing blood-brain barrier dam- age and cerebral edema.

关键词： neural regeneration brain injury diffuse brain injury blood-brain barrier brain edema vasculardensity cerebral blood flow vascular permeability brain water content grants-supported paper neuroregeneration

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Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage

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Neural Regeneration Research 2020年第7期15卷 1283-1289页

作者： Da-Qiang Ke Zhi-Yang Chen Zhou-Ling Li Xia Huang Hui Liang Department of Neurology First Affiliated Hospital School of Medicine Zhejiang University

Caspase-8 plays an important role in the mediation of inflammation and the effect of its role in subarachnoid hemorrhage remains *** nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome has been postulated to mediate inflammation during *** aim of the present study was to investigate the effects of caspase-8 inhibition on SAH injury and further elucidate the molecular *** this study,a subarachnoid hemorrhage model was established by endovascular perforation process in adult male Sprague-Dawley rats.Z-IETD-FMK(0.5,1,2 mg/kg;an inhibitor of caspase-8)was delivered via intravenous(tail vein)injection immediately after subarachnoid *** 12 hours of subarachnoid hemorrhage,western blot assay showed that the expression of cleaved caspase-8 was significantly increased at 12 hours,peaked at 24 hours,and then decreased at 72 hours after subarachnoid *** staining demonstrated that caspase-8 was expressed in microglia after subarachnoid hemorrhage.Z-IETDFMK significantly improved neurological deficits and reduced brain water content 24 hours after subarachnoid *** Morris water maze and rotarod test confirmed that Z-IETD-FMK significantly improved spatial learning and memory abilities and motor coordination at 21–27 days after subarachnoid ***,inhibition of caspase-8 activation reduced the expression of pyrin domain-containing 3,caspase-1,and interleukin-1βafter subarachnoid *** conclusion,our findings suggest that caspase-8 inhibition alleviates subarachnoid hemorrhage-induced brain injuries by suppressing *** study was approved by the Institutional Animal Ethics Committee of the First Affiliated Hospital,School of Medicine,Zhejiang University,China(approval No.2016-193)on February 25,2016.

关键词： brain water content caspase-8 inflammation Morris water maze neurological function neuroprotection pyrin domain-containing 3 rotarod test subarachnoid hemorrhage Z-IETD-FMK

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