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In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

Journal of Innovative Optical Health Sciences 2019年第1期12卷 62-71页

作者： Shaozhuang Yang Liwei Liu Yixin Chang Ningning Zhang Kun Liu Liang Hong Bingling Chen Yue Zhao Rui Hu Junle Qu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060P.R.China State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012P.R.China

In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain *** used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood *** to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 *** results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring.

关键词： Optical coherence tomography brain microcirculation cerebral blood vessels gold nanorods

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IN VIVO MAPPING brain microcirculation BY LASER SPECKLE CONTRAST IMAGING:A MAGNETIC RESONANCE PERSPECTIVE OF THEORETICAL FRAMEWORK

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 239-256页

作者： ZHENG WANG Center for Functional and Metabolic Mapping Robarts Research Institute Department of Medical Biophysics The University of Western Ontario LondonCanada

The fundamental limitations of most vascular-based functional neuroimaging techniques are placed by the fact how fine the brain regulates the blood supply *** vivo mapping of the cerebral microcirculation with high resolution and sensitivity hence becomes unprecedentedly *** paper reviews the theoretical background of the laser speckle contrast imaging(LSCI)technique and attempts to present a complete framework stemming from a simple biophysical *** the sensitivity analysis,more insights into the tool optimization are attained for in vivo *** questions of the technical aspects are discussed within this unified ***,it concludes with a brief perspective of future research in a way analogous to the magnetic resonance imaging(MRI)*** exploration could catalyze their development and initiate a technological fusion for precise assessment of blood flow across various spatial scales.

关键词： Laser speckle contrast imaging brain microcirculation functional neuroimaging magnetic resonance imaging

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