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brain metabolism in patients with vegetative state after post-resuscitated hypoxic-ischemic brain injury： statistical parametric mapping analysis of F-18 fluorodeoxyglucose positron emission tomography

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Chinese Medical Journal 2013年第5期126卷 888-894页

作者： Yong Wook Kim Hyoung Seop Kim Young-Sil An Department and Research Institute of Rehabilitation Medicine Yonsei University College of Medicine Seoul Republic of Korea Department of Physical Medicine and Rehabilitation NationalHealth Insurance Corporation Ilsan Hospital Gyonggi-doRepublic of Korea Department of Nuclear Medicine Ajou University School ofMedicine Suwon Republic of Korea

Background Hypoxic-ischemic brain injury （HIBI） after cardiopulmonary resuscitation is one of the most devastating neurological conditions that causing the impaired consciousness. However, there were few studies investigated the changes of brain metabolism in patients with vegetative state （VS） after post-resuscitated HIBI. This study aimed to analyze the change of overall brain metabolism and elucidated the brain area correlated with the level of consciousness （LOC） in patients with VS after post-resuscitated HIBI. Methods We consecutively enrolled 17 patients with VS after HIBI, who experienced cardiopulmonary resuscitation. Overall brain metabolism was measured by F-18 fluorodeoxyglucose positron emission tomography （F-18 FDG PET） and we compared regional brain metabolic patterns from 17 patients with those from 15 normal controls using voxel-by-voxel based statistical parametric mapping analysis. Additionally, we correlated the LOC measured by the JFK-coma recovery scale-revised of each patient with brain metabolism by covariance analysis. Results Compared with normal controls, the patients with VS after post-resuscitated HIBI revealed significantly decreased brain metabolism in bilateral precuneus, bilateral posterior cingulate gyrus, bilateral middle frontal gyri, bilateral superior parietal gyri, bilateral middle occipital gyri, bilateral precentral gyri （PFEw correctecd 〈0.0001 ）, and increased brain metabolism in bilateral insula, bilateral cerebella, and the brainstem （PFEWcorrectecd 〈0.0001 ）. In covariance analysis, the LOC was significantly correlated with brain metabolism in bilateral fusiform and superior temporal gyri （P uncorrected 〈0.005）. Conclusions Our study demonstrated that the precuneus, the posterior cingulate area and the frontoparietal cortex, which is a component of neural correlate for consciousness, may be relevant structure for impaired consciousness in patient with VS after post-resuscitated HIBI. In post-resuscitated HIBI, measurement of brain metabolism using PET images may be he

关键词： hypoxic-ischemic brain injury vegetative state brain metabolism

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Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography

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Neuroscience Bulletin 2022年第9期38卷 1057-1068页

作者： Wuxian He Hongtu Tang Jia Li Chenze Hou Xiaoyan Shen Chenrui Li Huafeng Liu Weichuan Yu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan430065China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhenChina College of Science Zhejiang University of TechnologyHangzhou310023China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou310027China Intelligent Optics&Photonics Research Center Jiaxing Research Institute of Zhejiang UniversityJiaxing314000China

In animal experiments,ischemic stroke is usually induced through middle cerebral artery occlusion(MCAO),and quality assessment of this procedure is crucial.However,an accurate assessment method based on 18F-fluorodeoxyglucose(FDG)positron emission tomography(PET)is still lacking.The difficulty lies in the inconsistent preprocessing pipeline,biased intensity normalization,or unclear spatiotemporal uptake of FDG.Here,we propose an image feature-based protocol to assess the quality of the procedure using a 3D scale-invariant feature transform and support vector machine.This feature-based protocol provides a convenient,accurate,and reliable tool to assess the quality of the MCAO procedure in FDG PET studies.Compared with existing approaches,the proposed protocol is fully quantitative,objective,automatic,and bypasses the intensity normalization step.An online interface was constructed to check images and obtain assessment results.

关键词： Ischemic stroke Middle cerebral artery occlusion brain metabolism FDG PET imaging SIFT classification

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Metabolic state oscillations in cerebral nuclei detected using two-photon fluorescence lifetime imaging microscopy

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Chinese Chemical Letters 2023年第1期34卷 300-303页

作者： Peng Zhou Jiawei Shen Jun Liang Tian Xue Yuansheng Sun Longhua Zhang Changlin Tian High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China The First Affiliated Hospital of USTC Division of Life Sciences and Medicineand Center for BioAnalytical ChemistryUniversity of Science and Technology of ChinaHefei 230026China ISS Inc.ChampaignIL 61822United States

The fluorescence lifetime of nicotinamide adenine dinucleotide(NADH),a key endogenous coenzyme and metabolic biomarker,can reflect the metabolic state of cells.To implement metabolic imaging of brain tissue at high resolution,we assembled a two-photon fluorescence lifetime imaging microscopy(FLIM)platform and verified the feasibility and stability of NADH-based two-photon FLIM in paraformaldehydefixed mouse cerebral slices.Furthermore,NADH based metabolic state oscillation was observed in cerebral nuclei suprachiasmatic nucleus(SCN).The free NADH fraction displayed a relatively lower level in the daytime than at the onset of night,and an ultradian oscillation at night was observed.Through the combination of high-resolution imaging and immunostaining data,the metabolic tendency of different cell types was detected after the first two hours of the day and at night.Thus,two-photon FLIM analysis of NADH in paraformaldehyde-fixed cerebral slices provides a high-resolution and label-free method to explore the metabolic state of deep brain regions.

关键词： NADH Fluorescence lifetime imaging microscopy brain metabolism Metabolic oscillation High resolution

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In Vivo Study of brain metabolism Using Nuclear Magnetic Resonance

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Tsinghua Science and Technology 1998年第3期3卷 62-64页

作者：罗雪春赵南明张日清李克玲蒋玉凤黄启福

Information on brain metabolism is very important, especially concerning the sequence of hypoxic ischemic episodes. Ultrasound, magnetic resonance image (MRI) and computer aided topography (CAT) allow visualization of changes due to hemorrhages. However, these methods do not detect the biochemical effects due to hypoxia and ischemia. This paper presents in vivo observations of brain metabolism attested by hypoxide and ischemia made using magnetic resonance spectroscopy(MRS), a noninvasive and nondestructive method which can identify the chemical compounds and monitor their changes during the biochemical reaction process for in vivo dynamic observation. 

关键词： brain metabolism NMR surface coil

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PET imaging in ischemic cerebrovascular disease:current status and future directions

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Neuroscience Bulletin 2014年第5期30卷 713-732页

作者： Wolf-Dieter Heiss Max Planck Institute for Neurological Research

Cerebrovascular diseases are caused by interruption or significant impairment of the blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological damage. These pathophysiological changes can be assessed by positron emission tomography （PET）, which permits the regional measurement of physiological parameters and imaging of the distribution of molecular markers. PET has broadened our understanding of the flow and metabolic thresholds critical for the maintenance of brain function and morphology： in this application, PET has been essential in the transfer of the concept of the penumbra （tissue with perfusion below the functional threshold but above the threshold for the preservation of morphology） to clinical stroke and thereby has had great impact on developing treatment strategies. Radioligands for receptors can be used as early markers of irreversible neuronal damage and thereby can predict the size of the final infarcts; this is also important for decisions concerning invasive therapy in large （＂malignant＂） infarctions. With PET investigations, the reserve capacity of blood supply to the brain can be tested in obstructive arteriosclerosis of the supplying arteries, and this again is essential for planning interventions. The effect of a stroke on the surrounding and contralateral primarily unaffected tissue can be investigated, and these results help to understand the symptoms caused by disturbances in functional networks. Chronic cerebrovascular disease causes vascular cognitive disorders, including vascular dementia. PET permits the detection of the metabolic disturbances responsible for cognitive impairment and dementia, and can differentiate vascular dementia from degenerative diseases. It may also help to understand the importance of neuroinflammation after stroke and its interaction with amyloid deposition in the development of dementia. Although the clinical application of PET investigations is limited, this technology had

关键词： stroke dementia PET brain metabolism brain ischemia

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Role of endothelial receptor-tyrosine kinase ErbB4 in regulating brain function

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中国药理学与毒理学杂志 2017年第5期31卷 466-466页

作者： LIU Xiu-xiu WU Gang LU Nan-nan LIU Qi-bing TIAN Yun YE Wei-feng JIANG Guo-jun TAO Rong-rong HAN Feng LU Ying-mei School of Medicine Zhejiang University City College College of Pharmaceutical Sciences Zhejiang University School of Pharmacy Hainan Medical College Department of Pharmacy Zhejiang Xiaoshan Hospital

OBJECTIVE The receptor-tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile.In the present study,we investigate the potential role of endothelial ErbB4 receptor signaling in the brain. METHODS ErbB4 conditional KO mice were generated by a lox P/Cre strategy. The experimenter conducting the experimentsand scoring the behavior was blinded to the genotype of the mice. Open field test,Y-maze and novel-object exploration test,novel object recognition task,step-through passive avoidance task,Morris water maze and memory reconsolidation task were carried out in WT and Cdh5-Cre; ErbB4^(loxP/loxP)mice. A high-resolution micro PET/CT scanner was used for brain metabolism imaging. RESULTS Here,we show that Cdh5Cre; ErbB4^(f/f) mice have lower levels ofexploration activity as measured by these particular behavior tests. However,our data indicate that conditional knockout of ErbB4 in endothelial cells did not impair working memory,memory acquisition,retrieval,and reconsolidation in mice. Furthermore,^(18)F-FDG-uptake was reduced in the Cdh5Cre; ErbB4^(f/f) mice as revealed by the significantly decreased SUVs in compared with the WT mice. Consistently,the immunoblot data demonstrate the downregulation of brain Glut1,phosphoULK1(Ser555) and TIGAR in the endothelial ErbB4 conditional knockout mice. Collectively,the endothelial ErbB4 deletion induced impairment in exploratory activity in adult mice,which may be due to the decreased brain energy metabolism. CONCLUSION Our study provides insight into the potential pathophysiological mechanisms of endothelial ErbB 4 and therapeutic strategies for neurological disorders.

关键词： ErbB4 endothelial CaMKⅡ exploratory behavior brain metabolism

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Human brain energy map computed on the basis of cellular staining from Bigbrain

Human brain energy map computed on the basis of cellular sta...

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中国神经科学学会第十二届全国学术会议

作者： Yuguo Yu Peter Herman Douglas L.Rothman Divyansh Agarwal Fahmeed Hyder School of Life Science and the Collaborative Innovation Center for brain Science the Center for Computational Systems Biology Fudan University Department of Radiology and Biomedical Imaging Yale University Magnetic Resonance Research Center Yale University Quantitative Neuroscience with Magnetic Resonance Core Center Yale University Department of Radiology and Biomedical Imaging Yale University Department of Biomedical Engineering Yale University Department of Molecular Cellular and Developmental Biology Yale University

The mammalian brain is organized on multiple scales of network connections and functionally dependent regions for sensory and cognitive functions. Normal mammalian brain functions are mainly supported by high ATP yield from glucose oxidation(CMRglc(ox)). How the metabolic energy used at the subcellular level is related to the large swathes within the brain are still not well-known yet. We first calculated a comprehensive CMRglc(ox)-derived energy budget for gray and white matter from the bottom-up, using biophysical properties of neurons and glia in conjunction with species-specific electrophysiological and morphological data. Comparing metabolic measurements by PET, 13 C MRS, and autoradiography in rat and human brain with budget-derived CMRglc(ox) revealed conserved properties. We have observed several conserved principles regarding the energy costs for brain signaling and non-signaling components for both human and rats. We observed that awake cortical signaling processes and mass-dependent nonsignaling processes demand 0% and 0% of CMRglc(ox), respectively. Inhibitory neurons and glia need 15-20% of total energy, with the rest is needed by excitatory neurons. Nonsignaling demands dominate in white matter. Although rat brain possesses smaller cells, due to higher firing rates in rat brain their functions demand 15-20% greater energy than their human brain counterparts.While neuronal energetics was governed by events associated with synaptic transmission and propagation of action potentials, glial energetics was dominated by nonsignaling needs. Then, we feed the energy budget calculations of individual neurons and glias into a 3-D human brain cell density map calculated based on Big brain cell-stained histological data, formulating a 3-D brain energy map with energy calculations in unit of either glucose in micromole/min/gram or ATP/min/gram in order to compare with PET measurement of actual brain. The quantitative comparison demonstrated a perfect match, indicating a first successful reconstruction of brain en

关键词： brain metabolism glucose PET neuron signaling glia electroencephalography energy budget

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