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Optical brain imaging： A Powerful Tool for Neuroscience

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Neuroscience Bulletin 2017年第1期33卷 95-102页

作者： Xinpei Zhu Yanfang Xia Xuecen Wang Ke Si Wei Gong Institute of Neuroscience Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Zhejiang University School of MedicineHangzhou 310058 China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering and the Collaborative Innovation Center for Brain Science Zhejiang University Hangzhou 310027 China

As the control center of organisms, the brain remains little understood due to its complexity. Taking advantage of imaging methods, scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods, optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here, we overview several optical imaging techniques in neuroscience of recent years, including brain clearing, the micro-optical sectioning tomography system, and deep tissue imaging.

关键词： brain imaging Tissue clearing MOSTOptical microscopy Deep tissue imaging

Non-invasive and low-artifact in vivo brain imaging by using a scanning acoustic-photoacoustic dual mode microscopy

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Chinese Physics B 2022年第4期31卷 385-393页

作者：陈文天陶超胡仔仲袁松涛刘庆淮刘晓峻 Ministry-of-Education Key Laboratory of Modern Acoustics Department of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Ophthalmology The First Affiliated Hospital of Nanjing Medial UniversityNanjing 210029China

Photoacoustic imaging is a potential candidate for in vivo brain imaging,whereas,its imaging performance could be degraded by inhomogeneous multi-layered media,consisted of scalp and skull.In this work,we propose a low-artifact photoacoustic microscopy(LAPAM)scheme,which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers.Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes,the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images.Phantom experiment is used to validate the effectiveness of this method.Furthermore,LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull.Experimental results show that the proposed method successfully achieves the low-artifact brain image,which demonstrates the practical applicability of LAPAM.This work might improve the photoacoustic imaging quality in many biomedical applications which involve tissues with complex acoustic properties,such as brain imaging through scalp and skull.

关键词： photoacoustic microscopy scanning acoustic microscopy noninvasive low-artifact brain imaging

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Nanoparticles as contrast agents for photoacoustic brain imaging

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聚集体(英文)

聚集体(英文) 2021年第1期2卷 4-19页

作者： Xingang Liu Yukun Duan Bin Liu Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhouChina

Photoacoustic(PA)imaging has emerged as a promising technique for real-time detection and diagnosis of brain-related pathologies,due to its advantages in deep penetration of ultrasound imaging and high resolution of optical fluorescence imaging.We herein provide an overview on the latest developments of nanoparticles as contrast agents specifically designed for PA imaging of brain tumor,and brain vascular and other brain-related diseases.Five design considerations of high-performance PA contrast agents for brain-related disease diagnosis are discussed,which include(1)strong absorption in NIR or NIR-Ⅱ window,(2)good biocompatibility,(3)high photothermal conversion efficiency,(4)precise nanostructure control,and(5)spe-cific targeting capability.Challenges and perspectives of developing more robust and universal contrast agents for enhanced PA imaging are discussed at the end.

关键词： brain imaging contrastagent nanoparticle photoacousticimaging

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease

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Phenomics 2023年第4期3卷 375-389页

作者： Mei Tian Chuantao Zuo Ali Cahid Civelek Ignasi Carrio Yasuyoshi Watanabe Keon Wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong Hong Zhang Molecular imaging-Based Precision Medicine Task Group of A3(China-Japan-Korea)Foresight Program PET Center Huashan HospitalFudan UniversityShanghai 200235China Human Phenome Institute Fudan UniversityShanghai 201203China Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China National Center for Neurological Disorders and National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Radiology and Radiological Science Division of Nuclear Medicine and Molecular ImagingJohns Hopkins MedicineBaltimore 21287USA Department of Nuclear Medicine Hospital Sant PauAutonomous University of BarcelonaBarcelona 08025Spain Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobeHyogo 650‑0047Japan Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Korea Department of Radiology Juntendo University HospitalTokyo 113‑8431Japan Diagnostic Department University Hospitals of Geneva and NIMTlabUniversity of GenevaGeneva 1205Switzerland Department of Nuclear Medicine and Molecular imaging Lausanne University HospitalLausanne 1011Switzerland Department of Nuclear Medicine Leipzig University Medical CenterLeipzig 04103Germany Key Laboratory of Medical Molecular imaging of Zhejiang Province Hangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang University Hangzhou 310007China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310007China 不详

Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining challenging.Amyloid positron emission tomography(PET)has become increasingly important in medical practice for patients with AD.To integrate and update previous guidelines in the field,a task group of experts of several disciplines from multiple countries was assembled,and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals,focusing on clinical scenarios,patient preparation,administered activities,as well as image acquisition,processing,interpretation and reporting.In addition,expert opinions,practices,and protocols of prominent research institutions performing research on amyloid PET of dementia are integrated.With the increasing availability of amyloid PET imaging,a complete and standard pipeline for the entire examination process is essential for clinical practice.This international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

关键词： Positron emission tomography(PET) Alzheimer’s disease Amyloid brain imaging Expert consensus

transcranial Direct Current Stimulation (tDCS) for the treatment and investigation of Phantom Limb Pain (PLP)

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Psychoradiology 2022年第1期2卷 23-31页

作者： Shahrzad Damercheli Malin Ramne Max Ortiz-Catalan Center for Bionics and Pain Research Molndal 43130Sweden Department of Electrical Engineering Chalmers University of TechnologyGothenburg 41296Sweden Operational Area 3 Sahlgrenska University HospitalMolndal 43180Sweden Department of Orthopaedics Institute of Clinical SciencesSahlgrenska AcademyUniversity of GothenburgGothenburg 41345Sweden

Phantom limb pain(PLP)is a complex medical condition that is often difficult to treat,and thus can become detrimental to patients’quality of life.No standardized clinical treatments exist and there is no conclusive understanding of the underlying mechanisms causing it.Noninvasive brain stimulation(NIBS)has been used to find correlations between changes in brain activity and various brain conditions,including neurological disease,mental illnesses,and brain disorders.Studies have also shown that NIBS can be effective in alleviating pain.Here,we examined the literature on a particular type of NIBS,known as transcranial direct current stimulation(tDCS),and its application to the treatment of PLP.We first discuss the current hypotheses on the working mech-anism of tDCS and then we examine published evidence of its efficacy to treat PLP.We conclude this article by discussing how tDCS alone,and in combination with brain imaging techniques such as electroencephalography(EEG)and magnetic resonance imagining,could be applied to further investigate the mechanisms underlying PLP.

关键词： Neuropathic pain phantom limb pain noninvasive brain modulation transcranial direct current stimulation pain rehabilitation brain imaging guided plasticity therapy

Proton magnetic resonance spectroscopy in substance use disorder: recent advances and future clinical applications

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Science China(Information Sciences) 2020年第7期63卷 5-18页

作者： Tianzhen CHEN Haoye TAN Huiting LEI Hang SU Min ZHAO Shanghai Mental Health Center School of Medicine Shanghai Jiao Tong University Shanghai Key Laboratory of Psychotic Disorders Institute of Psychological and Behavioral Science Shanghai Jiao Tong University CAS Center for Excellence in brain Science and Intelligence Technology (CEBSIT) Chinese Academy of Sciences

Proton magnetic resonance spectroscopy(1H-MRS) now is widely used in clinical researches for the measurement of compounds or metabolites in vivo, especially in neuropsychiatric diseases/disorders.Recently, there are many studies on substance use disorders utilizing 1H-MRS to explore the mechanism of brain metabolites. It is found that metabolites levels in substance users are changed compared with healthy controls. Furthermore, these changes also relate to behavior indices, and provide evidence for the impact on neuronal health, energy metabolism and membrane turnover. However, 1H-MRS is not yet a mature detection technology, and it still has many challenges in the application of the neuropsychiatric disorder area. The settings of test parameters and the inconsistency of results across different studies still plague the clinicians and technicians. This article is intended to provide an overview of basic theory and methods of 1H-MRS, and the literature reporting metabolites alterations in substance dependence, as well as the related neuropsychological performance. At last, we will discuss the forthcoming challenges and possible future direction in this area.

关键词： proton magnetic resonance spectroscopy substance use disorders brain imaging neurometabolites

Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN):what about the role of vascular changes,inflammation,Lewy body pathology?

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Translational Neurodegeneration 2018年第1期7卷 111-117页

作者： S.Gauthier H.Zhang K.P.Ng T.A.Pascoal P.Rosa-Neto McGill Center for Studies in Aging Douglas Mental Health Research InstituteMontrealCanada Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology National Neuroscience InstituteSingaporeSingapore

Background:The NIA-AA research framework proposes a biological definition of Alzheimer’s disease,where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.Discussion:Notwithstanding the fact that amyloid deposition in isolation is not associated with dementia,even the combined association of amyloid and tau pathology does not inevitably need to dementia over age 65.Other pathological factors may play a leading or an accelerating role in age-associated cognitive decline,including vascular small vessel disease,neuroinflammation and Lewy Body pathology.Conclusion:Research should aim at understanding the interaction between all these factors,rather than focusing on them individually.Hopefully this will lead to a personalized approach to the prevention of brain aging,based on individual biological,genetic and cognitive profiles.

关键词： Alzheimer’s disease Diagnosis Treatment Biomarkers Precision medicine Translational research brain imaging Database analysis Human volunteer cohorts

Subdural Hematoma Associated with High Altitude

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Chinese Medical Journal 2015年第3期128卷 407-408页

作者： Hui Lu Xiang-Bo Wang Yi Tang Department of Neurology Xuanwu Hospital Capital University of Medical Sciences 8eijing 100053 Chrna

Altitude illness is common in people ascending to more than 2500 m, especially when the ascent is rapid. In most cases, it may manifest as a mild and self-limited illness, but in a few cases it can develop into more severe forms, such as subdural hematoma （SDH）. Here we report a rare case of SDH evidenced by the neuro-imaging method before and after ascension to a high altitude.

关键词： Subdural Hematoma Altitude Illness brain imaging