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Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats

Acta Pharmacologica Sinica 2007年第2期28卷 273-278页

作者： Yan ZHAO Peng YUE Tao TAO~2 Qing-hua CHEN Shanghai Institute of Pharmaceutical Industry,Shanghai 200040,China Shanghai Institute of Pharmaceutical Industry Shanghai China

Aim:To determine the uptake extent of Huperzine A(Hup A)into the brain afterintranasal administration of Hup A in situ gel to rats,and to compare the pharma-cokinetic parameters between intranasal administration and iv and ***:Hup A was administered to male Sprague-Dawley rats via nasal,iv and oral routesat the dose of 166.7,166.7,and 500 μg/kg,*** and brain tissuesamples including the cerebrum,hippocampus,cerebellum and olfactory bulbwere collected,and the concentrations of Hup A in the samples were assayed *** area under the concentration-time curve(AUC0→6 h)and the ratio ofthe AUCbrain to the AUCplasma(drug targeting efficiency,DTE)were calculated toevaluate the brain targeting efficiency of the drug via 3 administration ***:The AUC0→6 h of the drug in the cerebrum,hippocampus,cerebellum,left olfactory bulb and right olfactory bulb after intranasal administration of theHup A in situ gel were 1.5,1.3,1.0,1.2,and 1.0 times of those after iv administrationof the injection,and 2.7,2.2,1.9,3.1,and 2.6 times of those after administration ofthe oral *** AUCbrain0→6 h/AUCplasma0→6 h of HupAin the cerebrum,hippocampus and left olfactory bulb following the intranasal administration dosewere significantly higher(Pbrain.

关键词： Huperzine A in situ gel brain distribution intranasal administration

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GluN2A versus GluN2B:twins,but quite different

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Neuroscience Bulletin 2013年第6期29卷 761-772页

作者： Xiao-Min Zhang Jian-Hong Luo Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine

N-Methyl-D-aspartate receptors（NMDARs） play vital roles in the central nervous system,as they are primary mediators of Ca2＋influx during synaptic *** subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties,as well as physiological and pathological functions,which make the NMDAR one of the most complex and elusive ionotropic glutamate *** this review,we focus on GluN2A and GluN2B,the primary NMDAR subunits in the cortex and hippocampus,and discuss their differences in developmental expression,brain distribution,trafficking,and functional properties during neuronal activity.

关键词： N-methyl-D-aspartate receptors GluN2A GluN2B developmental expression brain distribution function trafficking

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