检索结果-南通市图书馆

检索条件"主题词=brain Tumor targeting"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Novel Ginsenoside Rg3-based and Paclitaxel-coloaded liposomes for glioma target therapy

Novel Ginsenoside Rg3-based and Paclitaxel-coloaded liposome...

引用

2018年第十二届中国药物制剂大会

作者：朱颖 Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University ＆ Key Laboratory of Smart Drug Delivery Ministry of Education

Accumulation of most currently used anti-tumor agents in malignant glioma is far from perfect because of their non-targeted nature and difficulty in crossing the blood-brain barrier/blood-tumor barrier（BBB/BBTB）. Attempts to overcome this challenge have been focused on nanoparticle drug delivery system, such as nanoparticles, liposomes and other self-assembling systems. And various ligands are usually modified on the surface of these nanocarriers to construct brain-targeted delivery systems that can overcome BBB/BBTB barriers, target to tumor cells. However, most target ligands are polypeptides, whose preparation costs are high and process is complicated, and they often ignore the complicated brain tumor mircroenvironment（TME）, which contains many different noncancerous cell types in addition to cancer cells, also might limite the success of glioma treatment. Therefore, it is imperative to develop new nano preparations that can not only across BBB/BBTB but also regulate the TME to improve drug delivery efficiency and glioma treatment. In our previous studies, we have successfully developed a novel ginsenoside Rh2-based liposomes. It is a novel liposome prepared by replacing ginsenoside Rh2 with *** can not only break the clinical limitations of traditional liposomes due to the various defects of cholesterol but also mediate endocytosis through glucose receptors to the uptake of tumor cells. GLUT-1 can mediate the delivery across the BBB for those substances with similar structures of glucose, including mannose and glucose analogs. Ginsenoside Rg3 resembles with Rh2 in structure, and it contains 2 glucose molecules, which may account for helping the liposome cross the BBB/BBTB. Moreover, ginsenoside Rg3 has good anti-tumor activity. Besides when it combinate with other chemotherapeutic agents may lead to an improved treatment efficacy by synergistic effects. Furthermore, ginsenoside Rg3 also plays a role in the improvement of host immunity in tumor-bearing

关键词： ginsenoside Rg3 liposome brain tumor targeting paclitaxel TAM TME

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：