检索结果-南通市图书馆

Interactions Between Effects of Estrogen Receptor Gene Polymorphisms on BMD and Experiences of the First Spermorrhea in Chinese Han boys

引用

Biomedical and Environmental Sciences 2008年第2期21卷 129-136页

作者： JING YIN QIAN ZHANG XIAO-QI HU WEI-JING DU AI-LING LIU XIAO-YAN WANG ZHI-QIN TONG GUAN-SHENG MA National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China

Objective To study the interaction between polymorphisms of estrogen receptor （ER） gene and puberty on bone mineral density （BMD）. Methods One hundred and forty-six boys aged 13-17 years were divided into two groups according to their first sperrnorrhea. DNA was analyzed for Xba I and Pvu 1/genotypes by PCR-RFLP. BMD of the total body, forearm and lumbar spine was measured by dual-energy X-ray absorptiometry （DXA）. The relationship between polymorphisms of ER gene and BMD in these two groups was analyzed. Results The BMD at all sites in the sperrnorrhea group was significantly higher than that in the un-sperrnorrhea group. The independent contribution of ER genotypes to BMD at two pubertal stages was analyzed after adjusting co-variables. In the un-sperrnorrhea group, the BMD at distal 1/10 and 1/3 forearm of those carrying pp genotype was significantly higher than that of the non-carries, whereas in the sperrnorrhea group BMD in those carrying the same genotype was significantly lower than that in the non-carriers. Similar results were obtained by haplotype analysis. Multiple stepwise regression analysis showed that body weight, age and the first sperrnorrehea were the dominant determinants for BMD. BMD at forearm might be influenced by interaction between ER genotype and the first spermorrehea. Conclusion The polymorphisms of ER gene play a different role in BMD influenced by the first spermorrhea. Chinese boys carrying p or x allele should pay more attention to their bone mass.

关键词： BMD Puberty Hormones and receptors Polymorphism boys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacokinetic Studies of Factor VIII in Chinese boys with Severe Hemophilia A： A Single-Center Study

引用

Chinese Medical Journal 2018年第15期131卷 1780-1785页

作者： Zhen-Ping Chen Pei-jing Li Gang Li Ling Tang Ying-Zi Zhen Xin-Yi Wu Xiao-Ling Cheng Koon Hung Luke Victor S Blanchette Man-Chiu Poon Qiu-Lan Ding Run-Hui Wu Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology Discipline of Pediatrics Ministry of Education Beijing 100045 China Department of Pediatrics and Laboratory Medicine and Hemophilia Clinic Children's Hospital of Eastern Ontario and University of Ottawa National Key Ottawa. Ontario K1H8L1 Canada Department of Pediatrics and Child Health Evaluative Sciences Division of Hematology/Oncology Research Institute Hospital for Sick Children University of Toronto Toronto Ontario M5G lX8 Canada Department of Medicine Pediatrics and Oncology and Southern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program University of Calgary Foothills Hospital and Calgary Health Region Calgary Alberta T2N2T9 Canada Department of Laboratory Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China

Background： Although much attention has been paid to the pharmacokinetics （PKs） of different factor VIII （FVIlI） concentrates in persons with hemophilia A （HA）, limited information is available in young boys with severe HA. In this study, we aimed to assess the PK parameters of FVIII products in boys with severe HA in China. Methods： A total of 36 boys （plasma-derived [pd]-FVIII, n= 15; recombinant [r] FVIII, n = 21） were enrolled between January 2015 and May 2016 in Beijing Children＇s Hospital. PK characteristics of FVIII products were studied according to a reduced 4-sampling time point design （1 h, 9 h, 24 h, and 48 h postinfusion）. Results： The mean FVIII half-life （t1/2） was 10.99 ± 3.45 h （range 5.52-20.02 h）, the mean in vivo recovery （IVR） was 2.01 ± 0.42 IU/dl per IU/kg （range 1.24-3.02 IU/dl per IU/kg） and mean clearance （CL） of FVIII is 4.34 ± 1.58 ml·kg^-1·h ^-1 （range 2.29-7.90 ml·kg^-1·h·^-1）. We also analyzed the influence of several parameters that potentially modulate FVIII PK. The age was closely associated with FVIII half-life （R^2 = 0.32, P 〈 0.01 ）. The t1/2 of FVIII increased by 0.59 h per year. Besides age, yon Willebrand factor antigen （VWF：Ag） also was associated with FVIII half-life （R^2 = 0.52, P 〈 0.01）. Patients with blood Group O had a shorter FVIII halt-life than patients with non-O blood group （9.40 ± 0.68 h vs. 12.3 ± 0.79 h, t = 2.70, P = 0.01）. The FVIII IVR correlated with age （R^2 =0.21, P 〈 0.01） and VWF：Ag level （R^2 = 0.28, P 〈 0.01 ）. CL rates were taster in young patients and in those with low-VWF：Ag levels. CL rates of FVIII are higher in blood Group O versus non-blood Group O persons （5.02 ± 0.38 vs. 4.00 ± 0.32 ml·kg^-1·h^-1 , t = 2.53, P = 0.02）. Conclusions： Chinese boys with severe HA have similar PK values to other ethnic groups and large differences in FVIII PK between individual patients. Age, blood group, and VWF：Ag levels are important determining factors for FVlll CL.

关键词： boys Factor VIII Hemophilia A Phannacokinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

boys浅色时尚

引用

东西南北（大学生版） 2008年第6期 12-13页

时尚舞台似乎总是缺少男人话题。其实时尚是具有包容性的,不论你是男人还是男孩。本季,包容的浅色,开始"营养"男人。

关键词：时尚舞台 boys 简约设计正毛下角佩饰

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

爱篮球的boys

引用

作文大王(中高年级) 2007年第3期 64-65页

作者：卫晓云江苏省兴化市大垛中心小学 225731

你喜欢诗吗?你看我们伙伴写的诗多么美,多么有趣。如果把我们的心愿或有情趣的事写成小诗,一定会很动听。

关键词：篮球球类运动 boys

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

boys交往秘籍

引用

初中生学习(高) 2004年第Z2期 10-10页

作者：莫名黑龙江省林口县奎山乡奎山中学三年一班

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Epididymo-Orchitis in Pre-Pubertal Children. Epidemiology, Etiology, Management and Follow-Up Recommendations

引用

Open Journal of Urology 2013年第2期3卷 96-101页

作者： Sarel Halachmi Neri Katz Neonatal Intensive Care Unite Eadith Wolfson Medical Center Holon Israel Pediatric Urology Service Bnai Zion Medical Center Faculty of Medicine Technion Israeli Institute of Technology Haifa Israel

Epididymo-Orchitis (EO) is a disease that may affect males in all ages. Neonates and elderly patients may suffer from bacterial infection due to congenital or aging processes affecting the urinary tract. In sexually active post pubertal and young males sexually transmitted organisms may cause EO. EO is also prevalent in pre pubertal healthy boys;however in this group the etiology, the needed imaging modalities and proper management are not clearly defined yet. This manuscript will systematically review the various etiologies causing EO in pre-pubertal boys, discus about the needed proper imaging, and image interpretation, will give treatment and follow-up recommendations.

关键词： Gonad Inflammation Infection Pre-Pubertal boys Etiology Management Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical Profile and Outcome of Pediatric Acute Kidney Injury in Cameroon: Comparison between an Urban and a Semi-Urban Health Facility

引用

Open Journal of Nephrology 2018年第2期8卷 56-64页

作者： Fouda Menye Ebana Hermine Danielle Teuwafeu Denis George Halle Marie-Patrice Kaze Folefack Francois Ashuntantang Gloria Faculty of Medicine and Biomedical Sciences of Yaoundé University of Yaoundé I Yaoundé I Cameroon General Hospital of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Regional Hospital of Buea Buea Cameroon Faculty of Medicine and Pharmaceutic Sciences University of Douala Douala Cameroon Teaching Hospital of Yaoundé Yaoundé Cameroon General Hospital of Yaoundé Yaoundé Cameroon

Introduction: Pediatric Acute Kidney Injury (AKI) seems to be a major cause of morbidity and mortality in Subsahara Africa. However, data on its epidemiology are scare and mainly originate from tertiary and urban health facilities such as large university Teaching hospitals with a nephrology service. Objective: The aim of this study was to compare the epidemiology of pediatric AKI in urban and semi-urban health facility. Patients and method: We conducted a retrospective study of 16 months in a tertiary urban hospital (General Hospital of Douala) and a secondary semi-urban health facility (Region hospital of Buea). Diagnostic of AKI was done using usual criteria. Age, sex distribution, etiologies of AKI, access to dialysis, renal recovery at hospital discharge, at 1 and 3 months and patient survival at hospital discharge was compared. Results: A total of 31 patients were included (GD 17 and RHB 14). boys were more prevalent in the semi-urban setting (86% Vs 47% p = 0.029). Median age was comparable in the both group although most semi-rural patient were older (6.5 Vs 10 years p = 0.093). Hospital acquired AKI was only found in urban setting and account for 40% of pediatric urban AKI. Malaria related AKI (mainly black water fever) and sepsis were the main etiologies of AKI in urban and semi-urban milieu. Dialysis access was the same but 30% of children could not access to it in urban setting compare to none in semi-urban area. Reasons of non-access to dialysis were lack of pediatric material and financial constraints. In Hospital mortality was the same but was more severe amount patient who could not receive dialysis. Among the survivor, CKD was only found in urban setting. Conclusion: Although mainly due to malaria, pediatric AKI differs from urban tertiary and semi-urban secondary health facility in Cameroon. Hospital acquired AKI is only found in urban setting where children are younger and less boys. AKI in urban setting seems to be more severe with less access to

关键词： Pediatric AKI Urban Tertiary Health Facility Semi-Urban Secondary Health Facility Malaria Black Water Fever boys Hospital Acquired AKI CKD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do you Know what are students' favorite?

引用

考试与评价（英语七年级专刊） 2018年第12期 9-9,31页

作者：曲永华辽宁丹东

Hi,boys and girls!你们最喜欢的体育运动是什么呢?看看Paul跟他的朋友们喜欢的体育运动吧!

关键词： Hi 体育运动 boys 最喜欢 girls

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：