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Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5539-5555页

作者： Nana Bie Tuying Yong Zhaohan Wei Qingle Liang Xiaoqiong Zhang Shiyu Li Xin Li Jianye Li Lu Gan Xiangliang Yang National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and Technology430074WuhanChina Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology430074WuhanChina Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology430074WuhanChina

Immune checkpoint blockade(ICB)therapy,particularly antibodies targeting the programmed death receptor 1(PD-1)and its ligand(PD-L1),has revolutionized cancer ***,its efficacy as a standalone therapy remains *** ICB therapy in combination with chemotherapy shows promising therapeutic responses,the challenge lies in amplifying chemotherapy-induced antitumor immunity *** relies on efficient drug delivery to tumor cells and robust antigen presentation by dendritic cells(DCs).Here,we developed tumor-repopulating cell(TRC)-derived microparticles with exceptional tumor targeting to deliver doxorubicin(DOX@3D-MPs)for improve anti-PD-1 ***@3D-MPs effectively elicit immunogenic tumor cell death to release sufficient tumor *** shock protein 70(HSP70)overexpressed in DOX@3D-MPs contributes to capturing tumor antigens,promoting their phagocytosis by DCs,and facilitating DCs maturation,leading to the activation of CD8+T ***@3D-MPs significantly enhance the curative response of anti-PD-1 treatment in large subcutaneous H22 hepatoma,orthotopic 4T1 breast tumor and Panc02 pancreatic tumor *** results demonstrate that DOX@3D-MPs hold promise as agents to improve the response rate to ICB therapy and generate long-lasting immune memory to prevent tumor relapse.

关键词： immunity chemotherapy boost

Atomically dispersed Fe atoms anchored on N-doped carbon hollow nanospheres boost the electrocatalytic performance for oxygen reduction reaction

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Green Energy & Environment 2019年第3期4卷 208-209页

作者： Danye Liu Dong Chen Jun Yang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China

Oxygen reduction reaction(ORR)is the key reaction at the cathode of proton exchange membrane fuel cells(PEMFCs)and metal-air batteries(1)To address the challenges associated with Pt-based electrocatalysts having prominent activity for ORR,*** abundance,prohibitive cost,poor stability,and vulnerability to reaction intermediates,it is necessary to explore other cost-effective ORR electrocatalysts with competitive or even superior performance to promote the commercialization of the energy conversion devices.

关键词： Atomically dispersed Fe atoms anchored on N-doped carbon hollow nanospheres boost the electrocatalytic performance for oxygen reduction reaction SiO boost

Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan Zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,pbooster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

Exploiting buck-boost duality in dual active bridge modular multilevel converters to achieve high DC step ratios

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High Voltage 2021年第3期6卷 495-513页

作者： Sunny Kung Dalu Liu Chatumal Perera Moosa Moghimi Haji John Salmon Gregory Kish Department of Electrical and Computer Engineering University of AlbertaEdmontonAlbertaCanada

A previously unidentified duality between buck and boost configured dc‐ac modular multilevel converters(MMCs)is firstly *** with this insight,a new dual‐active‐bridge(DAB)‐MMC is proposed for high‐voltage dc(HVDC)‐to‐medium‐voltage dc(MVDC)power conversion that utilizes cascaded buck and boost dc-ac stages to obtain high dc step ***‐phase and three‐phase variants are *** compared with the conventional DAB‐MMC solution for the same dc step ratio,both the single‐phase and three‐phase topologies offer reduced MVDC side transformer winding current stresses,while the three‐phase topology also yields reduced MVDC side MMC submodule current *** former is achieved by having the freedom to design the transformer with a lower turns ratio,and the latter is achieved due to the inherent par-alleling of submodules on the MVDC side of the *** of the three‐phase topology reveals its low‐voltage side transformer winding current stresses can be reduced by a factor of 3.27.A generalized mathematical model of the proposed buck-boost DAB‐MMC is derived and used to propose a dynamic controller for both the single‐phase and three‐phase ***‐time simulations obtained from a real‐time digital simulator system that incorporates an FPGA‐based controller for the valve firing controls validate the proposed buck-boost DAB‐MMC operation and dynamic controls.

关键词： winding boost bridge

3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li Yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin Yang Xuesong Zhu Changshun Ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 474-480页

作者： Ming Zeng Fernando N Aguila Taral Patel Mark Knapp XueQiang Zhu XiLin Chen Phillip D Price Department of Radiation Oncology Mount Carmel Health System Cancer Center Sichuan Academy of Medical SciencesSichuan Provincial Hospital Central Ohio Surgical Associates Inc. Department of Hematology and Oncology Zangmeister Cancer CenterMount Carmel Health System Department of Oncology 307 Hospital

AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation *** the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical *** was followed by surgical tumor *** analyzed pathological completion response(p CR) rates its relationship with overall survival and ***:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for *** the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac *** Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was *** was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or *** 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),***:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications.

关键词： Intensity modulated radiation therapy Esophageal adenocarcinoma Simultaneous integrated boost Neoadjuvant chemoradiation Dose escalation Resection rate

Overcoming axon regeneration failure and psychopathology:how may gabapentinoids help boost CNS repair?

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Neural Regeneration Research 2023年第8期18卷 1703-1704页

作者： Haven I.Rodocker Andrea Tedeschi Department of Neuroscience Wexner Medical CenterThe Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

Spinal cord injury (SCI) at the cervical level compromises the function of both upper and lower extremities, thereby impeding an individual’s ability to complete daily tasks required for independent living and profoundly affecting the overall quality of life among individuals afflicted by SCI and their families. Recovery of spinal cord functions may be attained by promoting the sprouting of non-injured axons and/or the regeneration of damaged axons.

关键词： thereby boost axon

A molecular toolkit to boost functional genomic studies in transformation-recalcitrant vegetable legumes

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Horticulture Research 2023年第5期10卷 278-281页

作者： Xinyang Wu Peipei Zhang Shuting Chen Zixin Zhang Yihan Zhang Pingping Fang Kang Ning Ting Sun Pei Xu Key Laboratory of Specialty Agri-Product Quality and Hazard Controlling Technology of Zhejiang College of Life SciencesChina Jiliang UniversityHangzhouChina Zhejiang Lab HangzhouChina

Dear Editor Legumes,the second-largest family of crops,contribute over one-third of human dietary ***(Glycine max L.),common bean(Phaseolus vulgaris L.),pea(Pisum sativum L.),and cowpea(Vigna unguiculata L.)are among ... 详细信息

关键词： Leg crops boost

Optimization of light and temperature in indoor farming to boost anthocyanin biosynthesis and accumulation in Indigo Rose tomato

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Vegetable Research 2022年第1期2卷 170-180页

作者： Joanne Teo Raji Mohan Shilu Zhang Yuejing Gui Benny Jian Rong Sng In-Cheol Jang Zhongchao Yin Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Republic of Singapore Department of Biological Sciences 14 Science DriveNational University of SingaporeSingapore 117543Republic of Singapore

Anthocyanins are a group of flavonoids that are found ubiquitously in fruits and *** act as antioxidants in plants and are considered to have potential benefits to human *** tomato cultivar'Indigo Rose'produces purple-skinned fruits that are rich in anthocyanins in fruit *** current study focussed on the detection of anthocyanins and examined the expression profiling of anthocyanin biosynthetic and regulatory genes in Indigo Rose fruits grown under semi-closed greenhouse and fully controlled growth chamber *** anthocyanin content in Indigo Rose fruits grown under growth chamber conditions with a long-day photoperiod and ambient temperature was higher than those grown in the greenhouse with a short-day photoperiod and high *** indoor growth conditions,moderate to high intensity of artificial light(160−240μmol m^(−2) s^(−1))and relatively low temperature(20−25℃)promoted anthocyanin production and accumulation in Indigo Rose *** comparative studies on gene expression under different growth conditions also demonstrate that the expression levels of the structural and regulatory genes in the anthocyanin biosynthetic pathway have a positive correlation with the anthocyanin content in the fruit *** growth conditions identified in this study could be used to grow Indigo Rose in indoor farming in Singapore,where the tropical climate makes it challenging to set up a tomato plantation in an open field or greenhouse.

关键词： boost light fruits