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Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi Feng Yang Haifeng Tian Pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe cases.In this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser sintering.The results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant site.The accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative damage.This antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E.coli)and Gram-positive Staphylococcus aureus(S.aureus).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

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Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity

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Bio-Design and Manufacturing 2024年第2期7卷 105-120页

作者： Cijun Shuai Xiaoxin Shi Kai Wang Yulong Gu Feng Yang Pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Bacterial infection is a major problem following bone implant surgery.Moreover,poly-l-lactic acid/carbon nanotube/hydroxyapatite(PLLA/CNT/HAP)bone scaffolds possess enhanced mechanical properties and show good bioactiv-ityregardingbonedefectregeneration.Inthisstudy,wesynthesizedsilver(Ag)-dopedCNT/HAP(CNT/Ag-HAP)nanohybrids via the partial replacing of calcium ions(Ca2+)in the HAP lattice with silver ions(Ag+)using an ion doping technique under hydrothermal conditions.Speciﬁcally,the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT,and involved the partial replacement of Ca2+in the HAP lattice by doped Ag+as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal environment.The result-ing CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion(PBF-LB)to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial activity.We then found that Ag+,which pos-sesses broad-spectrum antibacterial activity,endowed PLLA/CNT/Ag-HAP scaffolds with this activity,with an antibacterial effectiveness of 92.65%.This antibacterial effect is due to the powerful effect of Ag+against bacterial structure and genetic material,as well as the physical destruction of bacterial structures due to the sharp edge structure of CNT.In addition,the scaffold possessed enhanced mechanical properties,showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa,respectively.Finally,the scaffold also exhibited good bioactivity and cytocompatibility,including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells(MG63 cells).

关键词： Ag-doped Carbon nanotube/hydroxyapatite(CNT/HAP) Antibacterial properties bone scaffold

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Personalized Design Method of Bionic bone scaffold with Voronoi Spacial Architecture

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Journal of Shanghai Jiaotong university(Science) 2022年第4期27卷 521-527页

作者：武力黄伟李学涛 School of Mechanical Engineering Dalian Jiaotong UniversityDalian116028LiaoningChina

In order to design and manufacture a bionic bone scaffold for personalized bone tissue repairing,we give the performance requirements and indicators,and propose a method of establishing a three-dimensional bone scaffold solid model based on the Voronoi architecture.The modeling parameters,number of seed points and scaling factor are found,which can control the model performance.The finite element analysis model of bone scaffold with different number of seed points and scaling factor is set up.By adopting the method of theory analysis,experiment and simulation calculation,the performance parameters of the porosity,the specific surface area and the elastic modulus of 15 sets of bionic bone scaffold model are obtained.The relation between the bone scaffold model parameters and the porosity,the porosity and the specific surface area,the porosity and the equivalent elastic modulus are established.The individual design method of Voronoi bone scaffold is proposed.In the condition of given equivalent elastic modulus and the defected shape of bone,the bone scaffold model with spatial Voronoi architecture which accords with the performance requirements can be designed and produced rapidly,which provides reference for the personalized treatment of bone defecting.

关键词： bone scaffold Voronoi architecture personalized design

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On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects

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Biomaterials Translational 2022年第2期3卷 142-151页

作者： Seyed Ataollah Naghavi Changning Sun Mahbubeh Hejazi Maryam Tamaddon Jibao Zheng Leilei Wang Chenrui Zhang Swastina Nath Varma Dichen Li Mehran Moazen Ling Wang Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing Systems Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Mechanical Engineering University College LondonLondonUK.

Polyether-ether-ketone(PEEK)is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive manufacturing.This is due to its excellent biocompatibility,good heat and chemical stability and similar mechanical properties which mimics natural bone.In this study,three replicates of rectilinear scaffolds were designed for compression,tension,three-point bending and torsion test with unit cell size of 0.8 mm,a pore size of 0.4 mm,strut thickness of 0.4 mm and nominal porosity of 50%.Stress-strain graphs were developed from experimental and finite element analysis models.Experimental Young’s modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression,427 and 6.96 MPa respectively for tension,257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion test.The finite element model was found to be in good agreement with the experimental results.Ductile fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold,which stems from the low crystallinity of additive manufacturing PEEK.The mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future,but the lower yield strength poses a design challenge.

关键词： additive manufacturing bone scaffold finite element analysis mechanical behaviour lattice structure PEEK scaffold

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A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles

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Bio-Design and Manufacturing 2021年第3期4卷 452-468页

作者： Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis School of Basic Medical ScienceCentral South UniversityChangsha 410013China School of Energy and Machinery Engineering Jiangxi University of Science and TechnologyNanchang 330013China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China

Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.

关键词： bone scaffold In situ growth Hydroxyapatite Antibacterial properties Surface modification

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3D-printed strontium-incorporatedβ-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity,enhanced strength,and excellent bioactivity

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Journal of Advanced Ceramics 2023年第9期12卷 1671-1684页

作者： Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao Chinese PLA Medical School Beijing 100853China Institute of Stomatology&Oral Maxilla Facial Key Laboratory First Medical Center of Chinese PLA General HospitalBeijing 100853China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this study,strontium-incorporatedβ-tricalcium phosphate(β-TCP),named Sr-TCP,bioceramic triply periodic minimal surface(TPMS)structured scaffolds were successfully fabricated by digital light processing(DLP)-based 3D printing technique,achieving high porosity,enhanced strength,and excellent bioactivity.The Sr-TCP scaffolds were first characterized by element distribution,macrostructure and microstructure,and mechanical properties.Notably,the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%,bringing a great mechanical breakthrough to porous scaffolds.Furthermore,the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line(MC3T3-E1)cells in both gene and protein aspects,verified by alkaline phosphatase(ALP)activity and polymerase chain reaction(PCR)assays.Overall,the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity,boosted strength,and superior bioactivity at the same time,serving as a promising approach for bone regeneration.

关键词： strontium β-tricalcium phosphate(β-TCP) digital light processing(DLP) 3D printing triply periodic minimal surface(TPMS) bone scaffold

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Biphasic calcium phosphate nano-composite scaffolds reinforced with bioglass provide a synthetic alternative to autografts in a canine tibiofibula defect model

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Chinese Medical Journal 2014年第7期127卷 1334-1338页

作者： Tang Dezhi Xu Guohua Yang Zhou Holz Jonathan Ye Xiaojian Cai Shu Yuan Wen Wang Yongjun Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China Shanghai Changzheng Hospital Shanghai 200003 China Department of Orthopaedics Center for Musculoskeletal Research University of Rochester Rochester New York 14642 USA Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin 300072 China

Background bone grafting is commonly used to repair bone defects.As the porosity of the graft scaffold increases,bone formation increases,but the strength decreases.Early attempts to engineer materials were not able to resolve this problem.In recent years,nanomaterials have demonstrated the unique ability to improve the material strength and toughness while stimulating new bone formation.In our previous studies,we synthesized a nano-scale material by reinforcing a porous β-tricalcium phosphate （β-TCP） ceramic scaffold with Na2O-MgO-P2O5-CaO bioglass （β-TCP/BG）.However,the in vivo effects of the β-TCP/BG scaffold on bone repair remain unknown.Methods We investigated the efficacy of β-TCP/BG scaffolds compared to autografts in a canine tibioflbula defect model.The tibioflbula defects were created in the right legs of 12 dogs,which were randomly assigned to either the scaffold group or the autograft group （six dogs per group）.Radiographic evaluation was performed at 0,4,8,and 12 weeks post-surgery.The involved tibias were extracted at 12 weeks and were tested to failure via a three-point bending.After the biomechanical analysis,specimens were subsequently processed for scanning electron microscopy analysis and histological evaluations.Results Radiographic evaluation at 12 weeks post-operation revealed many newly formed osseous calluses and bony unions in both groups.Both the maximum force and break force in the scaffold group （n=6） were comparable to those in the autograft group （n=6,P ＞0.05）,suggesting that the tissue-engineered bone repair achieved similar biomechanical properties to autograft bone repair.At 12 weeks post-operation,obvious new bone and blood vessel formations were observed in the artificial bone of the experimental group.Conclusions The results demonstrated that new bone formation and high bone strength were achieved in the β-TCP/ BG scaffold group,and suggested that the β-TCP/BG scaffold could be used as a synthetic alternative to autografts for the repair of bone defects.

关键词： biphasic calcium phosphate bone scaffold autograft bone defect tissue engineering bone

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Orthopedic implants and devices for bone fractures and defects:Past,present and perspective

再生工程(英文)

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再生工程(英文) 2020年第1期1卷 6-18页

作者： Tiffany Kim Carmine Wang See Xiaochun Li Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNew York 11794United States Department of Mechanical and Aerospace Engineering &Department of Materials Science and EngineeringUniversity of California Los AngelesLos AngelesCA 90095United States

bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any implant,careful consideration of the material used to create the implants to treat these problems is needed.If the incorrect material is chosen,the implants themselves can lead to bone fractures or defects,or bone healing may not take place at all.All three classes of biomaterials-metals,ceramics,and polymers-have been used in the treatment of both bone fractures and bone defects,and each has its own unique benefits and limitations for its applications.Furthermore,composites of these different materials have also been created to try to take advantage of all the different benefits offered by each different material.This review highlights different materials that have been used for the development of internal fixators and bone graft substitutes to treat fracture and bone defects as well as their limitations and needed future research.

关键词： bone scaffold bone fracture bone defect Orthopedic implant Orthopedic device

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Anisotropic characterization of different materialized scaffolds:A numerical study

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Biomedical Engineering Communications 2023年第2期2卷 35-42页

作者： Xu-Heng Cheng He-Ming Chen Qiang Chen School of Biological Science&Medical Engineering Southeast UniversityNanjing 210096China.

Ideal bone scaffold requires its mechanical properties to match those of natural bone.This work aimed to develop an anisotropic scaffold architecture,investigate the mechanical properties and anisotropy of the scaffold made of six biomedical materials by finite element method,and further compare them with the counterparts of natural bones for scaffold selection.The results showed that the mechanical properties of the scaffold constituent materials were positively correlated to those of the scaffolds but negatively correlated to the porosity.The modulus anisotropy was independent of materials at low porosity,and the strength anisotropy was weakly changed for high-strength materials but negatively correlated to porosity for low-strength materials.Plus,the modulus-strength chart of these materialized scaffolds against those of selected bones indicated that the mechanical match could be obtained by varying the anisotropic index.This work provided a constructing method for an anisotropic scaffold according to the structure-mechanical relationship of bone and could be helpful for scaffold design and selection to regenerate defective bones in clinical applications.

关键词： bone scaffold mechanical property anisotropy modulus-strength chart finite element method

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